Usage of Molybdenum Nanocrystalline Powder for Radioisotope Production

Ilyin, Alexander P.; Korovin, S. A.; Men’shikov, L. I.; Петрунин, В. Ф.; Semenov, Alexei; Chuvilin, D. Yu.

doi:10.1016/j.phpro.2015.09.055

Cited by 5 publications

(5 citation statements)

References 3 publications

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“…Pada umumnya, 99m Tc diperoleh dari generator 99 Mo/ 99m Tc. Pada saat ini sebagian pasokan 99 Mo seluruh dunia diperoleh dari hasil fisi uranium dari pengkayaan tinggi (High Enriched Uranium, HEU) dan sebagian kecil menggunakan pengkayaan rendah (Low Enriched Uranium,LEU) [2,3] . Penggunaan LEU bertujuan untuk mengurangi potensi adanya isu proliferasi atau penggunaan energi nuklir yang mengancam keamanan secara global.…”

Section: Pendahuluanunclassified

PEMBUATAN RADIONUKLIDA MOLIBDENUM-99 (99Mo) HASIL AKTIVASI NEUTRON DARI MOLIBDENUM ALAM UNTUK MEMPEROLEH TEKNESIUM-99m (99mTc)

Saptiama

Herlina

Sriyono

et al. 2016

urania

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PEMBUATAN RADIONUKLIDA MOLIBDENUM-99 (99Mo) HASIL AKTIVASI NEUTRON DARI MOLIBDENUM ALAM UNTUK MEMPEROLEH TEKNESIUM-99m (99mTc). Pembatasan penggunaan uranium sebagai target untuk produksi 99mTc menyebabkan rumah sakit di Indonesia kesulitan mendapatkan pasokan 99mTc. Saat ini 99mTc diperoleh dari 99Mo hasil fisi (pembelahan uranium). Pembuatan radionuklida 99Mo dari aktivasi neutron molibdenum alam (MoO3) di teras reaktor G.A Siwabessy digunakan sebagai metode alternatif untuk memperoleh 99mTc. Tujuan penelitian ini adalah untuk melakukan pembuatan radionuklida 99Mo dari aktivasi neutron molibdenum alam untuk memperoleh 99mTc. Serbuk MoO3 alam sebanyak 5 gram dikemas dalam ampul kuarsa dan dimasukkan ke dalam inner capsul selanjutnya dikemas menggunakan outer capsul sebagai bahan target. Bahan target diiradiasi di reaktor G.A Siwabessy selama 100 jam. Hasil perhitungan diperoleh aktivitas 99Mo sebesar 65 % dari nilai maksimum yang dapat diperoleh. MoO3 paska iradiasi dilarutkan dengan NaOH 4 M sehingga diperoleh larutan natrium molibdat (Na2MoO4). Radionuklida 99Mo dan 99mTc diukur menggunakan spektrometer gamma. Radionuklida 99Mo terdeteksi dalam produk larutan Na2MoO4 dengan aktivitas jenis 99Mo yang diperoleh sebesar 0,81 Ci 99Mo/g Mo. Radionuklida anak luruh 99mTc dipisahkan dari radionuklida induk 99Mo menggunakan kolom pemisah yang berisi material berbasis zirkonium (MBZ) sebagai penyerap 99Mo. Radionuklida 99mTc hasil pemisahan diperoleh dalam bentuk natrium pertehnetat (Na99mTcO4).dengan recovery yang masih rendah yaitu sekitar 52 hingga 71 %.Kata kunci: Molibdenum, teknesium, radionuklida, pemisahan, iradiasi. PRODUCTION OF ACTIVATED NEUTRON MOLYBDENUM-99 (99Mo) RADIONUCLIDE FROM NATURAL MOLYBDENUM TO OBTAIN TECHNETIUM-99m (99mTc). Uranium usage restriction causes the hospitals in indonesia difficult to obtain the suply of 99mTc. At Present, 99mTc is obtanied from molybdenum as a uranium fission product. Production of 99Mo radionuclide resulted from neutron activated natural molybdenum (MoO3) in G.A Siwabessy reactor could be used as a alternatif method for producing 99mTc. The aim of this research is synthesize of 99Mo radionuclide from neutron activated natural molybdenum (MoO3) to obtain 99mTc. The five grams of MoO3 powder was packed in a quartz ampule and inserted into inner capsule then also inserted into outer capsule as a target material. It was iradiated in G.A Siwabessy reactor for 100hours. Based on theoritical calculation, about 65 % of maximum 99Mo activity could be recovered. After Irradiation, MoO3 was dissolved by NaOH 4 M solution so it was natrium molybdate (Na2MoO4) solution. 99Mo and 99mTc radionuclide were analyzed using gamma spectrometer. 99Mo radionuclide was detected on Na2MoO4 solution as product that had specific activity of 0.81 Ci 99Mo/ g Mo. 99mTc as daughter radionuclide was separated from 99Mo as parent radionuclide using separated column containing zirconium based material (ZBM) as 99Mo adsobent. 99mTc radionuclide has been succesfully separated using ZBM column although recovery of 99mTc was quite low in which approximately 52 to 71 %. The 99mTc radionuclide was recovered in the form of sodium pertechnetate (NaTcO4) solution.Keywords: Molybdenum, technetium, radionuclide, separation, irradiation.

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Section: Pendahuluanunclassified

PEMBUATAN RADIONUKLIDA MOLIBDENUM-99 (99Mo) HASIL AKTIVASI NEUTRON DARI MOLIBDENUM ALAM UNTUK MEMPEROLEH TEKNESIUM-99m (99mTc)

Saptiama

Herlina

Sriyono

et al. 2016

urania

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“…Molybdenum is a transition metal that has one of the highest melting points (2623°C) of all metal elements, while its thermal expansion coefficient is one of the lowest of all engineering materials . Besides many applications based on its physical properties, molybdenum nanoparticles have also been used for radioactive applications, to produce the Mo‐99 radioisotope for the synthesis of Tc‐99m radiopharmaceuticals, one of the essential radiopharmaceuticals in medical use …”

Section: Introductionmentioning

confidence: 99%

“…2,3 Besides many applications based on its physical properties, molybdenum nanoparticles have also been used for radioactive applications, to produce the Mo-99 radioisotope for the synthesis of Tc-99m radiopharmaceuticals, one of the essential radiopharmaceuticals in medical use. 4 Molybdenum compounds are also used in many applications. In particular, molybdenum carbide is categorized as a catalytic material because of its unique physical and chemical characteristics.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of molybdenum carbide nanoparticles using pulsed wire discharge in mixed atmosphere of kerosene and argon

et al. 2019

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Pulsed wire discharge was used to prepare nanoparticles of molybdenum and its carbides from Mo wires in a gas mixture of argon and kerosene at pressures of 100, 50, and 25 kPa. The different pressures affected the carburization process and particle formation. The most effective pressure was 25 kPa, where the volume fraction of MoC was identified by Rietveld refinement of X‐ray diffraction data to be 98.4%. The particle size distribution was also obtained from transmission electron microscopy measurements, and the smallest geometric mean diameter was determined tobe 24.3 nm for the sample prepared at 25 kPa.

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“…When a thermal neutron is captured in a target nucleus only thermal energies are involved and these are far from sufficient to cause chemical changes; however, when a gamma ray is emitted from a slow-moving compound nucleus, chemical changes may occur. This effect (the Szilard-Chalmers effect) can cause persistent chemical changes [8].…”

Section: ■ Introductionmentioning

confidence: 99%

“…When irradiated, Mo atoms undergo transmutation from stable 98 Mo isotopes to radioactive 99 Mo isotopes. When 99 Mo is formed, the Szilard-Chalmers effect occurs as the nuclei achieve an excited state following neutron capture and during radiation of γ-quants, radiating recoil energy of E0~30-100 eV [8]. Recoil energy is much greater than the energy of the chemical bond of the atom in the crystal structure, so the radioactive 99 Mo atoms will be freed from the initial molybdenum compound structure, but stable 98 Mo will remain as the initial compound.…”

Section: ■ Introductionmentioning

confidence: 99%

Synthesis and Characterization of Molybdenum Phthalocyanine as Target Material for High Specific Activity Molybdenum-99 Production

Febrian¹,

Setiawan²,

Hidayati³

2019

Indones. J. Chem.

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High specific activity is a necessity in the fabrication of 99Mo/99mTc radioisotope generators. Recoil reaction, or the Szilard-Chalmers effect, is a method that could be used as an alternative method for increasing specific activity in radioisotope production in light of tightening regulation of highly enriched uranium (HEU) irradiation. Phthalocyanine compounds are usually used as the target material in recoil reactions for the production of high specific radioisotope activity via the (n,γ) reaction. Molybdenum phthalocyanine (Mo-Pc) could be a promising target material in recoil reactions for producing high specific activity of 99Mo. Mo-Pc was synthesized via solid-state reaction between ammonium heptamolybdate and phthalonitrile in a reflux system at 300 °C for 3 h. This optimum condition was identified after performing several variations of temperature and time of reaction, considering FTIR spectra, the yield of product and melting point of the product. XRD measurement showed that Mo-Pc synthesized at optimum condition was free from MoO2, phthalimide and unreacted molybdenum. Mo-Pc has UV-vis properties of Q-band absorption between 600 and 750 nm when dissolved in tetrahydrofuran, dimethylformamide and trifluoroacetic acid. Splitting at absorption peak in tetrahydrofuran and dimethylformamide solution indicated that protonation had occurred. This split peak did not appear in a trifluoroacetic acid solution. In the preliminary study of irradiation of 1 g Mo-Pc at 3.5x1012 n cm–2 s–1 neutron flux, followed by dissolution in tetrahydrofuran and extraction of Mo-99 into NaOH, we obtained Mo-99 solution with a specific activity of 682.35 mCi/g Mo, this being 254.61 times higher than in the regular MoO3 target.

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Usage of Molybdenum Nanocrystalline Powder for Radioisotope Production

Cited by 5 publications

References 3 publications

PEMBUATAN RADIONUKLIDA MOLIBDENUM-99 (99Mo) HASIL AKTIVASI NEUTRON DARI MOLIBDENUM ALAM UNTUK MEMPEROLEH TEKNESIUM-99m (99mTc)

PEMBUATAN RADIONUKLIDA MOLIBDENUM-99 (99Mo) HASIL AKTIVASI NEUTRON DARI MOLIBDENUM ALAM UNTUK MEMPEROLEH TEKNESIUM-99m (99mTc)

Synthesis of molybdenum carbide nanoparticles using pulsed wire discharge in mixed atmosphere of kerosene and argon

Synthesis and Characterization of Molybdenum Phthalocyanine as Target Material for High Specific Activity Molybdenum-99 Production

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