Use and Effectiveness of Sperm Cryopreservation for Adolescents and Young Adults: A 37-Year Bicentric Experience

Adam, Cécile; Deffert, Christine; Leyvraz, Céline; Primi, Marie-Pierre; Simon, Jean-Pascale; Popović, Maja; Benard, Julie; Bouthors, Thérèse; Girardin, Celine; Streuli, Isabelle; Vulliemoz, Nicolas; Gumy‐Pause, Fabienne

doi:10.1089/jayao.2020.0121

Cited by 6 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, it was suggested not to proceed with OTC in cases of systemic diseases such as leukemia, neuroblastoma, and Burkitt's lymphoma. However, studies that investigated the risk of relapse after OTT suggest that harvesting ovarian tissue while patients are in complete remission may be safer, especially since neither graft follicle density nor reproductive performance is significantly affected by chemotherapy administered before OTC [79,[85][86][87][88]. Dolmans et al observed a relapse in only 4.2% of cases, consistent with the data provided by Andersen et al (3.9%) [79].…”

Section: Fertility Preservation Methods: To Whom When and How They Sh...supporting

confidence: 72%

Fertility Preservation in Children and Adolescents during Oncological Treatment—A Review of Healthcare System Factors and Attitudes of Patients and Their Caregivers

Pawłowski,

Ziętara,

Michalczyk

et al. 2023

Cancers

View full text Add to dashboard Cite

Oncofertility is any therapeutic intervention to safeguard the fertility of cancer patients. Anti-cancer therapies (chemotherapy, radiation therapy, etc.) entail the risk of reproductive disorders through cytotoxic effects on gamete-building cells, especially those not yet fully developed. This literature review analyzes the available data on securing fertility in pediatric and adolescent populations to identify the methods used and describe aspects related to financing, ethics, and the perspective of patients and their parents. Topics related to oncofertility in this age group are relatively niche, with few peer-reviewed articles available and published studies mostly on adults. Compared to pubertal individuals, a limited number of fertility preservation methods are used for prepubertal patients. Funding for the procedures described varies from country to country, but only a few governments choose to reimburse them. Oncofertility of pediatric and adolescent patients raises many controversies related to the decision, parents’ beliefs, having a partner, ethics, as well as the knowledge and experience of healthcare professionals. As the fertility of young cancer patients is at risk, healthcare professionals should make every effort to provide them with an opportunity to fulfill their future reproductive plans and to have a family and offspring. Systemic solutions should form the basis for the development of oncofertility in pediatric and adolescent populations.

show abstract

Section: Fertility Preservation Methods: To Whom When and How They Sh...supporting

confidence: 72%

Fertility Preservation in Children and Adolescents during Oncological Treatment—A Review of Healthcare System Factors and Attitudes of Patients and Their Caregivers

Pawłowski,

Ziętara,

Michalczyk

et al. 2023

Cancers

View full text Add to dashboard Cite

show abstract

“…One study compared pre-treatment semen storage in cancer patients and reported, in addition to abnormal semen characteristics, a trend toward fewer straws (and thus lower sperm volume produced) among patients with HL ( P = 0.051) compared to other patients with an indication for sperm cryopreservation (i.e. sarcoma, testicular cancer, NHL, other malignant hemopathies or other/non-oncological indications) ( Adam et al , 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Reproductive ability in survivors of childhood, adolescent, and young adult Hodgkin lymphoma: a review

Drechsel

Pilon

Stoutjesdijk

et al. 2023

Human Reproduction Update

View full text Add to dashboard Cite

BACKGROUND Owing to a growing number of young and adolescent Hodgkin lymphoma (HL) survivors, awareness of (long-term) adverse effects of anticancer treatment increases. The risk of impaired reproductive ability is of great concern given its impact on quality of life. There is currently no review available on fertility after childhood HL treatment. OBJECTIVE AND RATIONALE The aim of this narrative review was to summarize existing literature on different aspects of reproductive function in male and female childhood, adolescent, and young adult HL survivors. SEARCH METHODS PubMed and EMBASE were searched for articles evaluating fertility in both male and female HL survivors aged <25 years at diagnosis. In females, anti-Müllerian hormone (AMH), antral follicle count, premature ovarian insufficiency (POI), acute ovarian failure, menstrual cycle, FSH, and pregnancy/live births were evaluated. In males, semen-analysis, serum FSH, inhibin B, LH, testosterone, and reports on pregnancy/live births were included. There was profound heterogeneity among studies and a lack of control groups; therefore, no meta-analyses could be performed. Results were presented descriptively and the quality of studies was not assessed individually. OUTCOMES After screening, 75 articles reporting on reproductive markers in childhood or adolescent HL survivors were included. Forty-one papers reported on 5057 female HL survivors. The incidence of POI was 6–34% (median 9%; seven studies). Signs of diminished ovarian reserve or impaired ovarian function were frequently seen (low AMH 55–59%; median 57%; two studies. elevated FSH 17–100%; median 53%; seven studies). Most survivors had regular menstrual cycles. Fifty-one studies assessed fertility in 1903 male HL survivors. Post-treatment azoospermia was highly prevalent (33–100%; median 75%; 29 studies). Long-term follow-up data were limited, but reports on recovery of semen up to 12 years post-treatment exist. FSH levels were often elevated with low inhibin B (elevated FSH 0–100%; median 51.5%; 26 studies. low inhibin B 19–50%; median 45%; three studies). LH and testosterone levels were less evidently affected (elevated LH 0–57%, median 17%; 21 studies and low testosterone 0–43%; median 6%; 15 studies). In both sexes, impaired reproductive ability was associated with a higher dose of cumulative chemotherapeutic agents and pelvic radiotherapy. The presence of abnormal markers before treatment indicated that the disease itself may also negatively affect reproductive function (Females: AMH<p10 9%; one study and Males: azoospermia 0–50%; median 10%; six studies). Reports on chance to achieve pregnancy during survivorship are reassuring, although studies had their limitations and the results are difficult to evaluate. In the end, a diminished ovarian reserve does not exclude the chance of a live birth, and males with aberrant markers may still be able to conceive. WIDER IMPLICATIONS This review substantiates the negative effect of HL treatment on gonadal function and therefore young HL survivors should be counseled regarding their future reproductive life, and fertility preservation should be considered. The current level of evidence is insufficient and additional trials on the effects of HL and (current) treatment regimens on reproductive function are needed. In this review, we make a recommendation on reproductive markers that could be assessed and the timing of (repeated) measurements.

show abstract

“…In male patients, therapies of certain solid tumors may carry the lowest risk of subsequent infertility, whereas higher risk is noted in hematologic and central nervous system cancers [46]. Although male patients may seek fertility preservation more often than female patients, the actual rates of use of cryopreserved sperm may be very low, 3% in one study, less than 10% for any fertility preservation method [47]. The utility of testicular biopsy for cryopreservation may have future viability if obtained at any point in cancer treatment; however, will likely be most effective earlier in the course of therapy [48].…”

Section: Discussionmentioning

confidence: 98%

Fertility preservation in children and young adults with cancer

Brungardt

Burns²,

Dasgupta

2021

Current Opinion in Pediatrics

View full text Add to dashboard Cite

Purpose of reviewThe issue of fertility preservation has become increasingly relevant as survival rates of children with cancer exceeds 80% at 5 years. Fertility preservation options are being utilized alongside less gonadotoxic therapeutic regimens in the treatment of these patients. The purpose of this review is to summarize the recent advances in fertility preservation in the pediatric, adolescent, and young adult population. Recent findingsEducation research involves both patient and provider; to increase understanding on both sides for improved adoption of techniques and higher rates of posttreatment fertility. Basic science research, specific to the pediatric population, has worked to further understanding of protective techniques and cryopreserved tissue transfer. Research on the techniques of preservation confirms the safety of surgical gonadal (ovarian and testicular) tissue retrieval for cryopreservation but a viable pathway for testicular tissue utilization, as it has for ovarian, has yet to be realized. Outcomes may be improving but it is apparent that robust registries are necessary to track patients long-term. Possibly the largest advancement in the recent past are group efforts, such as by PanCareLIFE, to create guidelines for these issues using larger cohorts and registries than were available.

show abstract

Use and Effectiveness of Sperm Cryopreservation for Adolescents and Young Adults: A 37-Year Bicentric Experience

Cited by 6 publications

References 31 publications

Fertility Preservation in Children and Adolescents during Oncological Treatment—A Review of Healthcare System Factors and Attitudes of Patients and Their Caregivers

Fertility Preservation in Children and Adolescents during Oncological Treatment—A Review of Healthcare System Factors and Attitudes of Patients and Their Caregivers

Reproductive ability in survivors of childhood, adolescent, and young adult Hodgkin lymphoma: a review

Fertility preservation in children and young adults with cancer

Contact Info

Product

Resources

About