Use of 3D printers to create a patient‐specific 3D bolus for external beam therapy

Burleson, Sarah; Baker, Jackie; Hsia, A; Xu, Zhigang

doi:10.1120/jacmp.v16i3.5247

Cited by 131 publications

(130 citation statements)

References 17 publications

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“…Made to order metal 3D printed devices (Hsu and Ellington 2015), 3D printed models for surgical planning (Pietrabissa et al 2015; Scawn et al 2015), and 3D printed tools (Burleson et al 2015) highlight some of the current and future biomedical applications of conventional 3D printing technologies. Bioprinting techniques have also been applied to bone tissue engineering.…”

Section: Applications Of Bioprintingmentioning

confidence: 99%

3D bioprinting for engineering complex tissues

Mandrycky

Wang

Kim

2016

Biotechnology Advances

1,416

1,046

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Bioprinting is a 3D fabrication technology used to precisely dispense cell-laden biomaterials for the construction of complex 3D functional living tissues or artificial organs. While still in its early stages, bioprinting strategies have demonstrated their potential use in regenerative medicine to generate a variety of transplantable tissues, including skin, cartilage, and bone. However, current bioprinting approaches still have technical challenges in terms of high-resolution cell deposition, controlled cell distributions, vascularization, and innervation within complex 3D tissues. While no one-size-fits-all approach to bioprinting has emerged, it remains an on-demand, versatile fabrication technique that may address the growing organ shortage as well as provide a high-throughput method for cell patterning at the micrometer scale for broad biomedical engineering applications. In this review, we introduce the basic principles, materials, integration strategies and applications of bioprinting. We also discuss the recent developments, current challenges and future prospects of 3D bioprinting for engineering complex tissues. Combined with recent advances in human pluripotent stem cell technologies, 3D-bioprinted tissue models could serve as an enabling platform for high-throughput predictive drug screening and more effective regenerative therapies.

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Section: Applications Of Bioprintingmentioning

confidence: 99%

3D bioprinting for engineering complex tissues

Mandrycky

Wang

Kim

2016

Biotechnology Advances

1,416

1,046

View full text Add to dashboard Cite

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“…The printing material was the clear-PLA, which had been evaluated in previous other studies as a bolus material [23]. The bolus structure for printing was generated automatically above the body structure following the shape of the patient’s skin in the TPS.…”

Section: Discussionmentioning

confidence: 99%

“…The bolus substance must be odorless, non-sticky, and harmless to the skin. In this study, thus, the polylactic acid (PLA) was adopted as a bolus material [16, 17]. We printed a patient-specific breast bolus for an anthropomorphic phantom and simulated a real patient treatment.…”

Section: Introductionmentioning

confidence: 99%

A Patient-Specific Polylactic Acid Bolus Made by a 3D Printer for Breast Cancer Radiation Therapy

Park¹,

Choi²,

Park³

et al. 2016

PLoS ONE

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PurposeThe aim of this study was to assess the feasibility and advantages of a patient-specific breast bolus made using a 3D printer technique.MethodsWe used the anthropomorphic female phantom with breast attachments, which volumes are 200, 300, 400, 500 and 650 cc. We simulated the treatment for a right breast patient using parallel opposed tangential fields. Treatment plans were used to investigate the effect of unwanted air gaps under bolus on the dose distribution of the whole breast. The commercial Super-Flex bolus and 3D-printed polylactic acid (PLA) bolus were applied to investigate the skin dose of the breast with the MOSFET measurement. Two boluses of 3 and 5 mm thicknesses were selected.ResultsThere was a good agreement between the dose distribution for a virtual bolus generated by the TPS and PLA bolus. The difference in dose distribution between the virtual bolus and Super-Flex bolus was significant within the bolus and breast due to unwanted air gaps. The average differences between calculated and measured doses in a 200 and 300 cc with PLA bolus were not significant, which were -0.7% and -0.6% for 3mm, and -1.1% and -1.1% for 5 mm, respectively. With the Super-Flex bolus, however, significant dose differences were observed (-5.1% and -3.2% for 3mm, and -6.3% and -4.2% for 5 mm).ConclusionThe 3D-printed solid bolus can reduce the uncertainty of the daily setup and help to overcome the dose discrepancy by unwanted air gaps in the breast cancer radiation therapy.

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“…Several studies have confirmed the advantages of electron conformal therapy performed using customized 3D-printed electron boluses and compensators over that performed with conventional ones [7, 8, 11, 12]. However, since these studies used the 3D-printed boluses only on phantoms and did not provide details of the procedures used, there remained a lack of information regarding their use with actual patients.…”

Section: Methodsmentioning

confidence: 99%

Clinical application of 3D-printed-step-bolus in post-total-mastectomy electron conformal therapy

Park

Jeon

et al. 2016

Oncotarget

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The 3D-printed boluses were used during the radiation therapy of the chest wall in six patients with breast cancer after modified radical mastectomy (MRM). We measured the in-vivo skin doses while both conventional and 3D-printed boluses were placed on the chest wall and compared the mean doses delivered to the ipsilateral lung and the heart. The homogeneity and conformity of the dose distribution in the chest wall for both types of boluses were also evaluated. The uniformity index on the chest skin was improved when the 3D-printed boluses were used, with the overall average skin dose being closer to the prescribed one in the former case (-0.47% versus -4.43%). On comparing the dose-volume histogram (DVH), it was found that the 3D-printed boluses resulted in a reduction in the mean dose to the ipsilateral lung by up to 20%. The precision of dose delivery was improved by 3% with the 3D-printed boluses; in contrast, the conventional step bolus resulted in a precision level of 5%. In conclusion, the use of the 3D-printed boluses resulted in better dose homogeneity and conformity to the chest wall as well as the sparing of the normal organs, especially the lung. This suggested that their routine use on the chest wall as a therapeutic approach during post-mastectomy radiation therapy offers numerous advantages over conventional step boluses.

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Use of 3D printers to create a patient‐specific 3D bolus for external beam therapy

Cited by 131 publications

References 17 publications

3D bioprinting for engineering complex tissues

3D bioprinting for engineering complex tissues

A Patient-Specific Polylactic Acid Bolus Made by a 3D Printer for Breast Cancer Radiation Therapy

Clinical application of 3D-printed-step-bolus in post-total-mastectomy electron conformal therapy

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