Use of 99mTc-MDP SPECT for assessment of mandibular growth: development of normal values

Fahey, Frederic H.; Abramson, Zachary; Padwa, Bonnie L.; Zimmerman, R.E.; Zurakowski, David; Nissenbaum, Mark; Kaban, Leonard B.; Treves, S. Ted

doi:10.1007/s00259-009-1337-0

Cited by 56 publications

(40 citation statements)

References 20 publications

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“…Furthermore, the mandibular condyle is a morphologically small structure relative to the SPECT spatial resolution; thus, the radioactivity detected in the condyle is mostly governed by the point spread function of the imaging method rather than by the shape of the condyle. 14 The present results also were confirmed by a previous study using SPECT/CT, which showed that SPECT and SPECT/CT had similar sensitivities (80%). 10 This study has a few limitations.…”

Section: Discussionsupporting

confidence: 90%

“…Moreover, maximum ROIs are not dependent on the position or size of the ROI as long as the maximum count per pixel is within the ROI and therefore are less operator dependent. 13,14 ROC analysis showed that the SPECTaver had the highest AUC of 0.899, which is consistent with a prior study using the same ROI method in which the AUC was 0.866 with the mean ROI method. 8 Moreover, the present study also showed that SPECT/CT and SPECT had similar diagnostic performance in the SPECTaver, SPECTmax, and SPECTCTmax methods (P > .05), but not in SPECTCTaver, which showed a significantly smaller AUC compared with the others (P < .05).…”

Section: Discussionsupporting

confidence: 87%

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Is Single-Photon Emission Computed Tomography/Computed Tomography Superior to Single-Photon Emission Computed Tomography in Assessing Unilateral Condylar Hyperplasia?

Liu

Shi

2019

Journal of Oral and Maxillofacial Surgery

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Purpose: Single-photon emission computed tomography (SPECT) with technetium-99m diphosphates plays an important role in assessing unilateral condylar hyperplasia (UCH). The aim of this study was to evaluate whether quantification methods of SPECT plus CT (SPECT/CT) based on precise region-ofinterest (ROI) drawings made under the guide of CT images were more accurate than conventional SPECT methods in the assessment of UCH growth. Materials and Methods:This study is a nonblinded retrospective case series. Patients with UCH who had undergone SPECT/CT were enrolled. CT images were used to guide ROI drawings around the anatomic contour of the affected and contralateral condyles on SPECT/CT images versus fixed ROIs on conventional SPECT images. Mean and maximum values within the ROIs were recorded to compute percentile ratios. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and receiver operating characteristic (ROC) curves were calculated separately for SPECT-based methods (SPECTaver, SPECTmax) and SPECT/CT methods (SPECTCTaver, SPECTCTmax). The area under the ROC curve of each method was calculated and compared pairwise.Results: Fifty-six patients (30 patients with progressive and 26 patients with nonprogressive mandibular asymmetry) were evaluated. SPECTmax had the highest sensitivity of 83.3%, followed by SPECTCTmax, SPECTaver, and SPECTCTaver. In contrast, SPECTaver, SPECTCTmax, and SPECTmax had similar specificities, PPVs, and NPVs. Nonetheless, SPECTCTaver had the lowest specificity, PPV, and NPV among all methods. ROC analysis also showed similar diagnostic performances among SPECTaver, SPECTmax, and SPECTCTmax (P > .05) and poorer diagnostic performance of SPECTCTaver compared with the other 3 methods (P < .05).Conclusions: The method of using ROIs drawn around the contour of the condyle on SPECT/CT images does not show improved accuracy over conventional SPECT-fixed ROI methods in assessing UCH.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

Is Single-Photon Emission Computed Tomography/Computed Tomography Superior to Single-Photon Emission Computed Tomography in Assessing Unilateral Condylar Hyperplasia?

Liu

Shi

2019

Journal of Oral and Maxillofacial Surgery

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“…47 Planar scintigraphy using 99m Tc-labeled methylene diphosphate, which distributes according to bone blood flow, can be used to evaluate mandibular growth at 1 time point. In the study by Fahey et al, 47 the mean measured ratio of right:left growth determined from 99m Tc-labeled methylene diphosphate uptake was 0.943 ± 0.116 in a symmetric adolescent population. Pripatnanont et al 48 reported a 4.75% ± 1.91% mean difference in isotope uptake in this population.…”

Section: Discussionmentioning

confidence: 99%

Congenital and acquired mandibular asymmetry: Mapping growth and remodeling in 3 dimensions

Solem

Ruellas

Miller

et al. 2016

American Journal of Orthodontics and Dentofacial Orthopedics

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Introduction Disordered craniofacial development frequently results in definitive facial asymmetries that can significantly impact a person's social and functional well-being. The mandible plays a prominent role in defining facial symmetry and, as an active region of growth, commonly acquires asymmetric features. Additionally, syndromic mandibular asymmetry characterizes craniofacial microsomia (CFM), the second most prevalent congenital craniofacial anomaly (1:3000 to 1:5000 live births) after cleft lip and palate. We hypothesized that asymmetric rates of mandibular growth occur in the context of syndromic and acquired facial asymmetries. Methods To test this hypothesis, a spherical harmonic-based shape correspondence algorithm was applied to quantify and characterize asymmetries in mandibular growth and remodeling in 3 groups during adolescence. Longitudinal time points were automatically registered, and regions of the condyle and posterior ramus were selected for growth quantification. The first group (n = 9) had a diagnosis of CFM, limited to Pruzansky-Kaban type I or IIA mandibular deformities. The second group (n = 10) consisted of subjects with asymmetric, nonsyndromic dentofacial asymmetry requiring surgical intervention. A control group (n = 10) of symmetric patients was selected for comparison. A linear mixed model was used for the statistical comparison of growth asymmetry between the groups. Results Initial mandibular shape and symmetry displayed distinct signatures in the 3 groups (P < 0.001), with the greatest asymmetries in the condyle and ramus. Similarly, mandibular growth had unique patterns in the groups. The dentofacial asymmetry group was characterized by significant asymmetry in condylar and posterior ramal remodeling with growth (P < 0.001). The CFM group was characterized by asymmetric growth of the posterior ramus (P < 0.001) but relatively symmetric growth of the condyles (P = 0.47). Conclusions Forms of CFM are characterized by active and variable growth of the dysplastic side, which has a distinct pattern from other disorders of mandibular growth.

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“…[33][34][35][36][37] The technetium 99 bone scan results exhibited an increased asymmetric activity in the right TMJ, indicating an active bone process in the right TMJ. In addition to the bone scan, a right posterior open bite and progressively worsening maxillary and mandibular asymmetry allowed a conclusion that the patient had an active right condylar hyperplasia.…”

Section: Report Of Casesmentioning

confidence: 96%

Algorithm for the Differential Diagnosis of Posterior Open Bites: Two Illustrative Cases

Ponsford

Stella

2013

Journal of Oral and Maxillofacial Surgery

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Use of 99mTc-MDP SPECT for assessment of mandibular growth: development of normal values

Cited by 56 publications

References 20 publications

Is Single-Photon Emission Computed Tomography/Computed Tomography Superior to Single-Photon Emission Computed Tomography in Assessing Unilateral Condylar Hyperplasia?

Is Single-Photon Emission Computed Tomography/Computed Tomography Superior to Single-Photon Emission Computed Tomography in Assessing Unilateral Condylar Hyperplasia?

Congenital and acquired mandibular asymmetry: Mapping growth and remodeling in 3 dimensions

Algorithm for the Differential Diagnosis of Posterior Open Bites: Two Illustrative Cases

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