Use of a Calcium Sulfate-Based Bone Graft Substitute for Benign Bone Lesions

Abstract

Twenty-three patients with a benign bone lesion grafted with calcium sulfate, with and without demineralized bone matrix, were reviewed. At a minimum of 1 year postoperatively, 21 patients had achieved between 76% and 100% bone repair based on anteroposterior and lateral radiographs. Overall, the mean Enneklng Functional Evaluation System score was 98%. Calcium sulfate is a well-tolerated, biodegradable, osteoconductive bone graft substitute. It is a reasonable alternative to autogenous bone graft for benign bone lesions.

Peri-Implant Bone Regeneration With Calcium Sulfate: A Light and Transmission Electron Microscopy Case Report

“…3,4 Calcium sulfate is a simple, highly biocompatible effective graft substitute with a very long clinical history. [5][6][7][8][9][10][11][12][13][14] It has been used in periodontal defects, endodontic treatments, postextraction sites, and maxillary sinus lifting procedures. 3,4,[15][16][17][18][19] Calcium sulfate as a membrane barrier has been used to prevent the loss of grafted material; it does not interfere with the healing processes.…”

Limitations and modifications in the clinical application of calcium sulfate

“…Resorption of calcium sulfate usually occurs faster than bone formation (31) . Previous studies reported that pure calcium sulfate resorbs over a period of 4-6 weeks in a contained osseous defect (31)(32)(33)(34).…”

“…Resorption of calcium sulfate usually occurs faster than bone formation (31) . Previous studies reported that pure calcium sulfate resorbs over a period of 4-6 weeks in a contained osseous defect (31)(32)(33)(34). Petruskevicius et al (35) do not recommend calcium sulfate for implantation in humans, as 6 weeks is too short a time for complete degradation.…”

Chemistry of Polymer and Ceramic-Based Injectable Scaffolds and Their Applications in Regenerative Medicine

“…Calcium sulfate (CaSO 4 ) cement (CSC) is a highly biocompatible material that is one of the simplest synthetic bone graft materials with the longest clinical history, spanning more than 100 years. − In its form known as plaster of Paris or gypsum, calcium sulfate has a long clinical history for use as a bone graft substitute. , However, after plaster of Paris is mixed with water the recrystallization process is random which results in defects in the crystalline structure . Surgical-grade CSCs developed in recent years overcome this problem.…”