Use of a compact pixellated gamma camera for small animal pinhole SPECT imaging

Zeniya, Tsutomu; Watabe, Hiroshi; Aoi, Toshiyuki; Kim, Kyeong Min; Teramoto, Noboru; Takeno, Takeshi; Ohta, Yoshihiro; Hayashi, Takuya; Mashino, H.; Ota, Toshihiro; Yamamoto, Seiichi; Iida, Hidehiro

doi:10.1007/bf03027376

Cited by 35 publications

(26 citation statements)

References 20 publications

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“…Our results for system sensitivity were also in general agreement with those for other small-animal scanners equipped with a single pinhole collimator and the same aperture size and radius of rotation [4,7]. Comparison to the latest small-animal SPECT system with their much number of detectors and pin-holes such as U-SPECT-II [6], and NanoSPECT [25], these systems provide much higher sensitivity than the Inveon SPECT.…”

Section: Discussionsupporting

confidence: 83%

“…Comparison to the latest small-animal SPECT system with their much number of detectors and pin-holes such as U-SPECT-II [6], and NanoSPECT [25], these systems provide much higher sensitivity than the Inveon SPECT. The energy resolution was worse for this system as compared with the semiconductor system (12.4%-5.6%) [11], which was comparable to the same Anger-type system [7,12]. The present results for tomographic spatial resolution and system sensitivity less lower than that for manufacturers datasheets.…”

Section: Discussioncontrasting

confidence: 55%

“…For PET, spatial resolution, absolute sensitivity, scatter fraction, and noise equivalent count (NEC) were evaluated. To compare the imaging capabilities of SPECT and PET, spatial resolution and sensitivity were evaluated using common phantoms: the micro-Derenzo phantom, [1,4,6,7], this size only was evaluated in this study.…”

Section: Physical Studymentioning

confidence: 99%

“…In the past several years, a large number of small-animal SPECT [4][5][6][7][8], PET [9][10][11][12], and CT systems have been developed and become commercially available.…”

Section: Introductionmentioning

confidence: 99%

“…The spatial transformation matrix for the registration is predetermined by a phantom scanning. A hardware approach would be the most useful and convenient method for small-animal imaging.In the past several years, a large number of small-animal SPECT [4][5][6][7][8], PET [9][10][11][12], and CT systems have been developed and become commercially available.Moreover, efforts to develop trimodality preclinical systems integrated in a common have not yet been reported.It is known that SPECT using a pinhole collimator has high spatial resolution, while PET has high sensitivity. This feature plays an important role when deciding whether to use SPECT or PET.…”

mentioning

confidence: 99%

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Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging

Magota

Kubo

Kuge

et al. 2010

Eur J Nucl Med Mol Imaging

105

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3Purpose: We analyzed the performance of the Inveon for an integrated small-animal PET/SPECT/CT system and compared the imaging capabilities of the SPECT and the PET components.Methods: For SPECT, energy resolution, tomographic spatial resolution, and system sensitivity were evaluated with 99m Tc solution using a single pinhole collimator. For PET, spatial resolution, absolute sensitivity, scatter fraction, and peak noise equivalent count (NEC) were evaluated. A micro-Derenzo phantom, cylindrical phantom, and National Electrical Manufacturers Association NU-4 image quality phantom were scanned to compare SPECT and PET image capabilities, and SPECT and PET bone imaging were performed on a normal rat in vivo.Results: SPECT spatial resolution was 0.84 mm full width at half maximum (FWHM) at a radius of rotation of 25 mm using the 0.5-mm pinhole aperture collimator, while PET spatial resolution was 1.63 mm FWHM at the center. SPECT system sensitivity at a radius of rotation of 25 mm was 35.3 cps/MBq (4 × 10 -3 %) using 0.5-mm pinhole aperture, while PET absolute sensitivity was 3.2% for 350-650 keV and 3.432 ns. Accordingly, the volume sensitivity of PET was three orders of magnitude 4 higher than that of SPECT.Conclusions: This integrated PET/SPECT/CT system provided high system performance with excellent spatial resolution for SPECT and sensitivity for PET.Based on tracer availability and system performance, SPECT and PET have complementary roles for multi-modality small-animal imaging.Key Words: integrated PET/SPECT/CT system; small-animal imaging; performance measurement; instrumentation; molecular imaging 5 INTRODUCTIONMolecular imaging of small laboratory animals using single photon emission tomography (SPECT), positron emission tomography (PET), and x-ray computed tomography (CT) has recently emerged as an important tool for the in vivo study of animal models of human disease. This imaging method enables longitudinal studies to be performed in the same animal, and animals can serve as their own control.SPECT and PET have been used in functional imaging, including brain, heart, gene expression, and oncology studies [1,2]. CT has also been used for anatomical imaging (e.g., bone imaging) because it provides high contrast between bone and soft tissue [3]. The use of SPECT, PET, and CT in combinations such as SPECT/CT, PET/CT, SPECT/PET, and SPECT/PET/CT-so-called "multi-modality imaging"-may enable the development of new and interesting protocols for investigating many biological phenomena more effectively than is possible using SPECT, PET, or CT modalities alone. Using these techniques, lesions visualized by functional imaging can be correlated with anatomic imaging. In general, CT is also used for attenuation and scatter correction of SPECT and PET images. However, in this 6 study, neither attenuation nor scatter correction was performed.Integration of SPECT, PET, and CT images can be achieved by a "software approach" that fuses the images acquired by separate scanners. These techniques, however, are hamper...

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Section: Discussionsupporting

confidence: 83%

Section: Discussioncontrasting

confidence: 55%

Section: Physical Studymentioning

confidence: 99%

“…In the past several years, a large number of small-animal SPECT [4][5][6][7][8], PET [9][10][11][12], and CT systems have been developed and become commercially available.…”

Section: Introductionmentioning

confidence: 99%