Use of a Double-Cone Coil in Transcranial Magnetic Stimulation for Depression Treatment

Monteiro, Dennison Carreiro; Cantilino, Amaury

doi:10.1111/ner.12896

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…Although no significant differences between two groups were detected, the response rates were in line with the usual rTMS treatment response outcome for TRD patient in both protocols [3]. Likewise, our remission rate was in line with previous studies using conventional rTMS [2], but rather low regarding other reports using DC-TMS (34.7e47.6%) [6]. The follow-up duration and assessments were insufficient to evaluate potential time impact and delayed effects on remission or response rates.…”

supporting

confidence: 87%

Double cone coil rTMS efficacy for treatment-resistant depression: A prospective randomized controlled trial

et al. 2020

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supporting

confidence: 87%

Double cone coil rTMS efficacy for treatment-resistant depression: A prospective randomized controlled trial

et al. 2020

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“…A limited number of studies have compared the response rate amongst such coils. For example, the H-coil showed a 46% response rate at four weeks of treatment which increased to 81% at 22 weeks; double-cone coils have reported a response rate of 40-52.4% (37). One review reported noticeable higher response rate with H-coil than figure-8 coil (38) while a randomized controlled trial reported no significant difference in response rate between the double-cone coil and figure-8 coil (39).…”

Section: Discussionmentioning

confidence: 99%

Moving towards precision TMS? Evaluating individual differences and reproducibility of personalized stimulation targets in UK Biobank

Zhao,

Cui

et al. 2024

Preprint

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Objective: Personalized transcranial magnetic stimulation (TMS) targeting, guided by functional connectivity (FC), shows potential in treating depression. The present study aims to map individual FC peak location using UK Biobank, to evaluate individual differences and reproducibility of FC-based targets. Methods: We analyzed UK Biobank resting-state fMRI (rfMRI) of 35,423 participants, identifying individual FC peak locations on the dorsolateral prefrontal cortex (DLPFC) that functionally connected to the subcallosal cingulate, amygdala, and ventromedial prefrontal cortex, respectively. Euclidean distance between each participant's individual peak and group-average peak was calculated. With follow-up rfMRI of 1341 participants, within-subject FC peak location changes were calculated. We also compared common TMS targets and random locations for their median distance to individual peaks in a permutation test. Results: Seed-based FC analyses revealed large differences in the individual FC peak location on DLPFC: the mean distance from the individual peaks to group-average peak ranged from 14.24 to 29.92mm; 70% to 94% of participants were >10mm away from the group-average peak and potentially located outside of the TMS effective area with common TMS coils. Similar variability was observed in within-subject peak locations across two fMRI assessments. Common TMS targets and the group-average FC peak showed no significant difference in median distances to individual FC peaks when compared to random locations. Conclusions: FC peak location shows wide inter- and intra- individual variability. We further highlight limited advantage of group-based FC as TMS target. These findings provide insights to help guide neuromodulation techniques for depression.

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“…The two-coil or double-cone coil is a new device composed of two large circular wings, fixated at a 120 angle. Among the diverse coils existent in the market, this one has demonstrated the best balance between the depth and focal length of the stimulus, because it is the most focal coil that can reach deep targets within the energy limit of standard TMS devices (Monteiro & Cantilino, 2019). Kavanaugh et al (2018) was the only one to use this device.…”

Section: Two-coil Devicementioning

confidence: 99%

Use of transcranial magnetic stimulation (TMS) for studying cognitive control in depressed patients: A systematic review

Hernández-Sauret,

Martin de la Torre,

Redolar-Ripoll

2024

Cogn Affect Behav Neurosci

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Major depressive disorder (MDD) is a debilitating mental disorder and the leading cause of disease burden. Major depressive disorder is associated with emotional impairment and cognitive deficit. Cognitive control, which is the ability to use perceptions, knowledge, and information about goals and motivations to shape the selection of goal-directed actions or thoughts, is a primary function of the prefrontal cortex (PFC). Psychotropic medications are one of the main treatments for MDD, but they are not effective for all patients. An alternative treatment is transcranial magnetic stimulation (TMS). Previous studies have provided mixed results on the cognitive-enhancing effects of TMS treatment in patients with MDD. Some studies have found significant improvement, while others have not. There is a lack of understanding of the specific effects of different TMS protocols and stimulation parameters on cognitive control in MDD. Thus, this review aims to synthesize the effectiveness of the TMS methods and a qualitative assessment of their potential benefits in improving cognitive functioning in patients with MDD. We reviewed 21 studies in which participants underwent a treatment of any transcranial magnetic stimulation protocol, such as repetitive TMS or theta-burst stimulation. One of the primary outcome measures was any change in the cognitive control process. Overall, the findings indicate that transcranial magnetic stimulation (TMS) may enhance cognitive function in patients with MDD. Most of the reviewed studies supported the notion of cognitive improvement following TMS treatment. Notably, improvements were predominantly observed in inhibition, attention, set shifting/flexibility, and memory domains. However, fewer significant improvements were detected in evaluations of visuospatial function and recognition, executive function, phonemic fluency, and speed of information processing. This review found evidence supporting the use of TMS as a treatment for cognitive deficits in patients with MDD. The results are promising, but further research is needed to clarify the specific TMS protocol and stimulation locations that are most effective.

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Use of a Double-Cone Coil in Transcranial Magnetic Stimulation for Depression Treatment

Cited by 6 publications

References 29 publications

Double cone coil rTMS efficacy for treatment-resistant depression: A prospective randomized controlled trial

Double cone coil rTMS efficacy for treatment-resistant depression: A prospective randomized controlled trial

Moving towards precision TMS? Evaluating individual differences and reproducibility of personalized stimulation targets in UK Biobank

Use of transcranial magnetic stimulation (TMS) for studying cognitive control in depressed patients: A systematic review

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