Use of a fast EM algorithm for 3D image reconstruction with the YAP–PET tomograph

Motta, A.; Damiani, C.; Guerra, A. Del; Domenico, Giovanni Di; Zavattini, G.

doi:10.1016/s0895-6111(02)00034-4

Cited by 30 publications

(21 citation statements)

References 16 publications

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“…The average specific radioactivity at the time of injection was 166 GBq/mmol (range: 63-257 GBq/mmol). Sinograms were reconstructed using the expectation maximization algorithm with 20 iterations, which yields an image resolution of 1.9 mm full-width-at-half-maximum (Motta et al, 2002).…”

Section: Positron Emission Tomography Imagingmentioning

confidence: 99%

Chronic Δ9-Tetrahydrocannabinol Exposure Induces a Sensitization of Dopamine D2/3 Receptors in the Mesoaccumbens and Nigrostriatal Systems

Ginovart

Tournier

Moulin-Sallanon

et al. 2012

Neuropsychopharmacol

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Δ⁹-tetrahydrocannabinol (THC), through its action on cannabinoid type-1 receptor (CB₁R), is known to activate dopamine (DA) neurotransmission. Functional evidence of a direct antagonistic interaction between CB₁R and DA D₂-receptors (D₂R) suggests that D₂R may be an important target for the modulation of DA neurotransmission by THC. The current study evaluated, in rodents, the effects of chronic exposure to THC (1 mg/kg/day; 21 days) on D₂R and D₃R availabilities using the D₂R-prefering antagonist and the D₃R-preferring agonist radiotracers [¹⁸F]fallypride and [³H]-(+)-PHNO, respectively. At 24 h after the last THC dose, D₂R and D₃R densities were significantly increased in midbrain. In caudate/putamen (CPu), THC exposure was associated with increased densities of D₂R with no change in D₂R mRNA expression, whereas in nucleus accumbens (NAcc) both D₃R binding and mRNA levels were upregulated. These receptor changes, which were completely reversed in CPu but only partially reversed in NAcc and midbrain at 1 week after THC cessation, correlated with an increased functionality of D₂/₃R in vivo, based on findings of increased locomotor suppressive effect of a presynaptic dose and enhanced locomotor activation produced by a postsynaptic dose of quinpirole. Concomitantly, the observations of a decreased gene expression of tyrosine hydroxylase in midbrain together with a blunted psychomotor response to amphetamine concurred to indicate a diminished presynaptic DA function following THC. These findings indicate that the early period following THC treatment cessation is associated with altered presynaptic D₂/₃R controlling DA synthesis and release in midbrain, with the concurrent development of postsynaptic D₂/₃R supersensitivity in NAcc and CPu. Such D₂/₃R neuroadaptations may contribute to the reinforcing and habit-forming properties of THC.

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Section: Positron Emission Tomography Imagingmentioning

confidence: 99%

Chronic Δ9-Tetrahydrocannabinol Exposure Induces a Sensitization of Dopamine D2/3 Receptors in the Mesoaccumbens and Nigrostriatal Systems

Ginovart

Tournier

Moulin-Sallanon

et al. 2012

Neuropsychopharmacol

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“…PET scans started 60 min after tracer injection and lasted for 30 min (6 frames of 5 min each). PET data were acquired in list mode using the full axial acceptance angle of the scanner (3-dimensional mode) and then reconstructed with the expectation maximization algorithm (15).…”

Section: Pet Studiesmentioning

confidence: 99%

Evaluation of the Role of Tumor-Associated Macrophages in an Experimental Model of Peritoneal Carcinomatosis Using ¹⁸F-FDG PET

et al. 2011

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PET is widely used at the clinical and preclinical levels for tumor assessment and evaluation of treatment efficacy. Here, we established and took advantage of a preclinical model of peritoneal carcinomatosis to evaluate the contribution of inflammatory infiltrating macrophages in tumor progression that was followed using 18 F-FDG PET. Methods: Groups of mice with peritoneal carcinomatosis were longitudinally evaluated with 18 F-FDG PET. Intraperitoneal depletion of macrophages was achieved by an approach (i.e., administration of clodronate encapsulated into liposomes) that proved to be safe and effective. Sham liposomes were used in control animal cohorts. Results: 18 F-FDG PET allowed us to detect and monitor peritoneal lesion growth and diffusion. Macrophage-depleted animals showed a substantial reduction in tumor burden paralleled by a decrement in the extent of radioactivity distribution. A significant correlation between lesion dimension and metabolic volume was observed not only in macrophage-depleted but also in sham-treated mice. Conclusion: 18 F-FDG PET allowed a noninvasive detection of peritoneal carcinomatosis lesions. Although macrophages play a key role in the early growth and spreading of lesions in the peritoneal cavity, neoplastic cells apparently represent the major player in this system in the uptake of 18 F-FDG.

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“…Reconstruction of the axial and coronal slices and the 3D view of the cylinder were performed by Filtered back projection (FBP), MLEM and SART algorithms. The images quality was evaluated by RMS contrast and SNR factors [29][30][31]. …”

Section: Image Qualitymentioning

confidence: 99%

Design and performance evaluation of a high resolution IRI-microPET preclinical scanner

rad

Peyvandi²,

Lehdarboni³

et al. 2015

Nuclear Instruments and Methods in Physics Research Section A:

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Use of a fast EM algorithm for 3D image reconstruction with the YAP–PET tomograph

Cited by 30 publications

References 16 publications

Chronic Δ9-Tetrahydrocannabinol Exposure Induces a Sensitization of Dopamine D2/3 Receptors in the Mesoaccumbens and Nigrostriatal Systems

Chronic Δ9-Tetrahydrocannabinol Exposure Induces a Sensitization of Dopamine D2/3 Receptors in the Mesoaccumbens and Nigrostriatal Systems

Evaluation of the Role of Tumor-Associated Macrophages in an Experimental Model of Peritoneal Carcinomatosis Using ¹⁸F-FDG PET

Design and performance evaluation of a high resolution IRI-microPET preclinical scanner

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Use of a fast EM algorithm for 3D image reconstruction with the YAP–PET tomograph

Cited by 30 publications

References 16 publications

Chronic Δ9-Tetrahydrocannabinol Exposure Induces a Sensitization of Dopamine D2/3 Receptors in the Mesoaccumbens and Nigrostriatal Systems

Chronic Δ9-Tetrahydrocannabinol Exposure Induces a Sensitization of Dopamine D2/3 Receptors in the Mesoaccumbens and Nigrostriatal Systems

Evaluation of the Role of Tumor-Associated Macrophages in an Experimental Model of Peritoneal Carcinomatosis Using 18F-FDG PET

Design and performance evaluation of a high resolution IRI-microPET preclinical scanner

Contact Info

Product

Resources

About

Evaluation of the Role of Tumor-Associated Macrophages in an Experimental Model of Peritoneal Carcinomatosis Using ¹⁸F-FDG PET