Hybrid membrane-sorption systems are used to solve the problems of the gas mixtures separation, as air enrichment with oxygen or compressed air drying. Investigation of the waste flow of the PSA stage showed that the flow contains a significant amount of the target component. Thus, it is possible to increase the efficiency of the plant without additional energy costs by implementing a scheme, in which waste flow is used for expulsion. Considered scheme with the sorbent regeneration by the method of blowdown is applicable for various gas mixtures separation, in which it is necessary to separate out the low-sorption component. A demanded application of this scheme can be the solution of the air drying problem.