Use of a hydrogel polymer for reproducible surface enhanced Raman optical activity (SEROA)

Pour, Saeideh Ostovar; Bell, Steven E. J.; Blanch, Ewan W.

doi:10.1039/c0cc05284a

Cited by 45 publications

(39 citation statements)

References 25 publications

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“…Another typical problem is the instability of colloidal particles, hampering accumulation of the spectra. Various ways were therefore suggested to stabilize the colloids, such as by a permanent coating or creating a protective polymer layer …”

Section: Raman Optical Activitymentioning

confidence: 99%

Recent Trends in Chiroptical Spectroscopy: Theory and Applications of Vibrational Circular Dichroism and Raman Optical Activity

2020

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Chiroptical spectroscopy exploring the interaction of matter with polarized light provides many tools for molecular structure and interaction studies. Here, some recent discoveries are reviewed, primarily in the field of vibrational optical activity. Technological advances results in the development of more sensitive vibrational circular dichroism (VCD), Raman optical activity (ROA) or circular polarized luminescence (CPL) spectrometers. Significant contributions to the field also come from the light scattering and electronic structure theories, and their implementation in computer systems. Finally, new chiroptical phenomena have been observed, such as enhanced circular dichroism of biopolymers (protein fibrils, nucleic acids), plasmonic and resonance chirality‐transfer ROA experiments. Some of them are not yet understood or attributed to instrumental artifacts so far. Nevertheless, these unknown territories also indicate the vast potential of the chiroptical spectroscopy, and their investigation is even more challenging.

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Section: Raman Optical Activitymentioning

confidence: 99%

Recent Trends in Chiroptical Spectroscopy: Theory and Applications of Vibrational Circular Dichroism and Raman Optical Activity

2020

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“…[43][44][45][46] As a given chiroptical spectroscopic method may not give complete and entirely correct structural information for a given molecule, the simultaneous use of more than one spectroscopic method may provide the complete information. [62][63][64][65] The chiroptical variant of Raman scattering, ROA, is proven to be an effective tool to determine the configuration, conformation, and behavior of chiral molecules in recent years, 43,45,[66][67][68][69][70][71][72][73][74][75][76] and thus a presumably good candidate for the study of sulfur chirality. 48 The high polarizability of sulfur atom makes Raman spectroscopy a sensitive technique to identify sulfur compounds, and much effort has been focused on correlation between C-S, S-S stretching modes and the S-S dihedral angle.…”

Section: Introductionmentioning

confidence: 99%

“…48 The high polarizability of sulfur atom makes Raman spectroscopy a sensitive technique to identify sulfur compounds, and much effort has been focused on correlation between C-S, S-S stretching modes and the S-S dihedral angle. [62][63][64][65] The chiroptical variant of Raman scattering, ROA, is proven to be an effective tool to determine the configuration, conformation, and behavior of chiral molecules in recent years, 43,45,[66][67][68][69][70][71][72][73][74][75][76] and thus a presumably good candidate for the study of sulfur chirality. However, the application of ROA to chiral sulfur compounds has been limited to a few cases on the S-S bridge conformation, 50,77 and there is no previous ROA study on either sulfinamides or thiosulfinates.…”

Section: Introductionmentioning

confidence: 99%

Chiral Sulfur Compounds Studied by Raman Optical Activity: tert‐Butanesulfinamide and its Precursor tert‐Butyl tert‐Butanethiosulfinate

Qiu¹,

Li²,

Lü

et al. 2012

Chirality

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Two chiral sulfur compounds, tert-butyl tert-butanethiosulfinate (1) and tert-butanesulfinamide (2), with inversion of configuration, have been studied by Raman optical activity (ROA) and electronic circular dichroism combined with density functional theory calculation. With the S-S linkage in 1, the couplings between the two tertiary carbon atoms often generate large ROA signals, whereas the tertiary carbon atom itself generally makes a large contribution to ROA signals in 2 for similar vibrational modes. The conformational dependence of ROA parameters provides probing conformation around the S-S bond from a new perspective. The simultaneous use of electronic circular dichroism and ROA is warranted to extract reliable conformational information. ROA provides a suitable candidate for the stereochemical study of chiral sulfur compounds, especially its capability of sensing the conformation around the S-S bond.

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“…The possibility of a large increase in the sensitivity of ROA of biomolecules via surface enhanced Raman scattering (SERS) is attractive [1], but reliable experimental data so far are scarce and rather disappointing. Although genuine SERS ROA has now been observed in the form of mirror-image bands for D-and L-ribose [89], and modelled theoretically [83], the technique does not yet appear to be useful for the routine study of biomolecules. A nonlinear version of ROA has been realized recently by means of coherent anti-Stokes Raman scattering (CARS) [54].…”

Section: Future Directionsmentioning

confidence: 99%

The development of biomolecular Raman optical activity spectroscopy

Barron

2015

BSI

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Abstract. Following its first observation over 40 years ago, Raman optical activity (ROA), which may be measured as a small difference in the intensity of vibrational Raman scattering from chiral molecules in right-and left-circularly polarized incident light or, equivalently, the intensity of a small circularly polarized component in the scattered light using incident light of fixed polarization, has evolved into a powerful chiroptical spectroscopy for studying a large range of biomolecules in aqueous solution. The long and tortuous path leading to the first observations of ROA in biomolecules in 1989, in which the author was closely involved from the very beginning, is documented, followed by a survey of subsequent developments and applications up to the present day. Among other things, ROA provides information about motif and fold, as well as secondary structure, of proteins; solution structure of carbohydrates; polypeptide and carbohydrate structure of intact glycoproteins; new insight into structural elements present in unfolded protein sequences; and protein and nucleic acid structure of intact viruses. Quantum chemical simulations of observed Raman optical activity spectra provide the complete three-dimensional structure, together with information about conformational dynamics, of smaller biomolecules. Biomolecular ROA measurements are now routine thanks to a commercial instrument based on a novel design becoming available in 2004.

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Use of a hydrogel polymer for reproducible surface enhanced Raman optical activity (SEROA)

Cited by 45 publications

References 25 publications

Recent Trends in Chiroptical Spectroscopy: Theory and Applications of Vibrational Circular Dichroism and Raman Optical Activity

Recent Trends in Chiroptical Spectroscopy: Theory and Applications of Vibrational Circular Dichroism and Raman Optical Activity

Chiral Sulfur Compounds Studied by Raman Optical Activity: tert‐Butanesulfinamide and its Precursor tert‐Butyl tert‐Butanethiosulfinate

The development of biomolecular Raman optical activity spectroscopy

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