Use of a New Topical Anesthetic Agent (Dyclone) in Peroral Endoscopy

Fa, Hughes; Burwell,; Jw, Pate

doi:10.1016/s0096-5588(20)30437-2

Cited by 7 publications

(1 citation statement)

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“…Dyclonine (4-butoxy–piperidinyl phenylacetone hydrochloride) has been used clinically since 1956 as a local anaesthetic due to low toxicity, rapid onset, and a good safety profile [ 1 ]. It is a ketone-based compound structurally distinct from many other common local anaesthetics such as lidocaine and procaine, and therefore it can be safely administered to patients with procaine allergies [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Disturbance of consciousness caused by dyclonine hydrochloride mucilage: a case report

Wang,

Wen,

Wen

et al. 2024

BMC Anesthesiol

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Background Dyclonine hydrochloride mucilage is a topical anaesthetic formulated for mucosal surfaces. It is employed frequently for topical anaesthesia of the pharynx prior to endoscopic examinations such as electronic gastroscopy, and few adverse reactions have been reported. This article describes a patient who experienced a transient but severe disturbance of consciousness following oral dyclonine hydrochloride mucilage administration. Case presentation A 75-year-old female presenting with gastrointestinal bleeding was examined by electronic gastroscopy. Six minutes after oral dyclonine hydrochloride mucilage administration, the patient entered a comatose-like state accompanied by loss of limb muscle tone and profuse perspiration. This response was not accompanied by changes in cardiac rhythm, blood pressure, or respiration rate, suggesting an effect on higher brain centres. After ten minutes, the patient’s symptoms were alleviated. Conclusion We suggest that sites of dyclonine hydrochloride mucilage use be equipped with appropriate rescue devices for these rare events.

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Section: Introductionmentioning

confidence: 99%