Use of a New Ziprasidone-Selective Electrode in Mixed Solvents and Its Application in the Analysis of Pharmaceuticals and Biological Fluids

Abstract

The construction and characterization of a new ion-selective electrode for the determination of the antipsychotic ziprasidone in mixed solvents is presented. The electrode contains a plasticized polymeric membrane based on a ziprasidone-tetraphenylborate ion-exchanger. The influence of membrane composition on the electrode response towards ziprasidone in hydroalcoholic solutions was studied. The electrode displayed a stable response in a 2:3 (v/v) methanol/water medium from a ziprasidone concentration of 3 × 10−6 M with a fast response time of less than 20 s. The electrode also showed good selectivity towards ziprasidone over common inorganic and organic compounds and several species with pharmacological activity. The electrode was successfully applied to the determination of ziprasidone in pharmaceuticals and human urine and serum.

Ecofriendly Long Life Nanocomposite Sensors for Determination of Carbachol in Presence of Choline: Application in Ophthalmic Solutions and Biological Fluids

“…Our eco-friendly, organic, solvent-free proposed sensors also showed excellent correlation coefficients. Organic solvents that are commonly used in fabricating sensors, such as THF [28,38,39], are considered as volatile organic compounds (VOCs), which are irritants and are flammable, thereby causing adverse health effects such as eye irritation and headaches. VOCs are also a hazardous environmental concern as they can form low-level ozone through free radicals or oxidation processes [40].…”

Solid-phase extraction for RP-HPLC/UV determination of ziprasidone at presence its main metabolite in urine

“…Several authors describe techniques for determining the presence of ziprasidone in biological material (plasma, serum, brain) using LC/MS, HPLC/MS, HPLC/UV, HPLC with fluorescence detector, UPLC/UVand the potentiometric method (García et al, 2011;Mercolini et al, 2011;Marghade et al, 2012;Sampedro et al, 2012;Sreedasyam et al, 2012;Rao et al, 2013;Mercolini et al, 2014;Sistik, 2016;Wang and Li, 2017). Preparation and analysis of samples in the described techniques were carried out in several steps and were generally timeconsuming.…”