Use of a Panel of Tumor Markers (Carcinoembryonic Antigen, Cancer Antigen 125, Carbohydrate Antigen 15–3, and Cytokeratin 19 Fragments) in Pleural Fluid for the Differential Diagnosis of Benign and Malignant Effusions

Porcel, José M.; Vives, Manuel; Esquerda, Aureli; Salud, Antonieta; Pérez, Begoña Feliu; Rodríguez-Panadero, Francisco

doi:10.1378/chest.126.6.1757

Cited by 194 publications

(185 citation statements)

References 21 publications

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“…Some markers classified as tumor associated antigens are produced by various organs and are not specific to cancer but associated with cancer, such as, cancer antigen (CA) 125, CA153, CA199 (Watanabe, 1996;Malati, 2007). Now, levels of pleural effusion CEA, AFP, CA125, CA153 and CA199 have been assayed in many studies focusing on differentiating benign and malignant pleural effusions (Botte et al, 1990;Cascinu et al, 1997;Porcel et al, 2004;Shitrit et al, 2005;Gaspar et al, 2008;Liang et al, 2008). But there is as yet no evidence that PE tumor markers were employed in predicting the cause of MPE.…”

Section: Introductionmentioning

confidence: 99%

CEA, AFP, CA125, CA153 and CA199 in Malignant Pleural Effusions Predict the Cause

Wang¹,

Wu²,

Wang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Introductionmentioning

confidence: 99%

CEA, AFP, CA125, CA153 and CA199 in Malignant Pleural Effusions Predict the Cause

Wang¹,

Wu²,

Wang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…At present there are evidences to demonstrate that pleural fluid mesothelin, MMP-7 and MMP-10 may provide additional value over pleural fluid cytology in patients with an undiagnosed pleural effusions (Davies et al, 2009;Cheng et al, 2012). Unfortunately, conventional tumor markers had already failed to show adequate sensitivity and specificity for their routine clinical use, including carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), and cytokeratin 19 fragments (CYFRA 21-1) (Alataş et al, 2001;Porcel et al, 2004;Shitrit et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Clinical Impact and Reliability of Carbonic Anhydrase XII in the Differentiation of Malignant and Tuberculous Pleural Effusions

Liu¹,

Jing²,

Guo³

2013

Asian Pacific Journal of Cancer Prevention

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Objective: To assess the practical utility of pleural fluid carbonic anhydrase XII (CAXII) quantification for differential diagnosis of effusions. Materials and Methods: Fluid was collected prospectively from fifty patients presenting with lymphocytic pleural effusions for investigation and CAXII was quantified by ELISA. Results: Pleural fluid CAXII concentrations were significantly higher in lung cancer patients (n=30) than in tuberculous controls (n=20). The sensitivity and specificity of this biomarker were 60%and 75%, respectively. CAXII measurement was not inferior to cytological examination in the diagnosis and exclusion of pleural effusions from lung cancer patitents (sensitivity 60% vs. 57%; specificity 75% vs. 100%; positive predictive value 77%; negative predictive value 54%). In patients with negative cytology, it offered a sensitivity of 54%. Conclusions: Pleural fluid CAXII is elevated in pleural effusions from lung cancer patients. Measurement of CAXII may be used in the future as a valuable adjunct to cytology in the diagnostic assessment of patients with pleural effusions related to lung cancer, especially when cytological examination is inconclusive.

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“…Combinations of tumor markers, however, could help select patients with negative pleural effusion cytologic results for additional diagnostic studies. Moreover, additional immunostaining or other specific staining improves the diagnostic yield to some extent, though the promptness of diagnosis is adversely impaired (Kuenen-Boumeester et al, 1996 ;Porcel et al, 2004;Lee and Chang, 2005;Shitrit et al, 2005;Westfall et al, 2010 ;Su et al, 2011). Methods such as fluorescence in situ hybridization analysis, image analysis cytometry, and PCR, are more sensitive than standard cytologic studies (Fieglure, 2005;Holloway et al, 2006;Sriram et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

A New Cancer Cell Detection Method Using an Infectivity-enhanced Adenoviral Vector

Uchino

Takayama

Nakagaki

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Cytological examination is widely used as a diagnostic tool because of the ease of collecting cells from the involved area. However, the diagnostic yield of cytological examination is unsatisfactory; the reasons include sampling error, poorly prepared samples, small numbers of malignant cells, and low grades of cellular atypia. In this study, we focused on the high infectivity of adenovirus towards epithelial cells and applied the luciferaseexpressing adenoviral vector to a new cancer cell detection tool. In addition, adenoviral infectivity was enhanced by modifying viral fiber proteins. The sensitivity of the diagnostic tool was tested using the NCI-H1299 lung cancer cell line, and validated in body fluid samples from cancer patients with a variety of etiology. Results showed that the adenovirus efficiently transfected NCI-H1299 with high sensitivity. Only 10 cancer cells were sufficient for detection of luciferase signals. In body fluid samples, the adenovirus confirmed the diagnosis for malignant and benign cancer, but not in non-epithelial cell derived samples. This study provides proof-of-concept for a more reliable and sensitive diagnostic tool for epithelium-derived cancer.

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Use of a Panel of Tumor Markers (Carcinoembryonic Antigen, Cancer Antigen 125, Carbohydrate Antigen 15–3, and Cytokeratin 19 Fragments) in Pleural Fluid for the Differential Diagnosis of Benign and Malignant Effusions

Cited by 194 publications

References 21 publications

CEA, AFP, CA125, CA153 and CA199 in Malignant Pleural Effusions Predict the Cause

CEA, AFP, CA125, CA153 and CA199 in Malignant Pleural Effusions Predict the Cause

Clinical Impact and Reliability of Carbonic Anhydrase XII in the Differentiation of Malignant and Tuberculous Pleural Effusions

A New Cancer Cell Detection Method Using an Infectivity-enhanced Adenoviral Vector

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