Use of a simulation model to evaluate control programmes against
            <i>Taenia solium</i>
            cysticercosis.

Gonzalez, A. E.; Gilman, R. H.; Garcı́a, Héctor H.; Lopez, Teresa

doi:10.1079/9780851996288.0437

Cited by 19 publications

(32 citation statements)

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“…As TSTC is a zoonosis it is important to set the goals for both taeniosis and porcine cysticercosis control and define whether the first target should be morbidity control or transmission control (Bergquist et al 2009). Development of surveillance strategies will also be essential, as the two published T. solium models predict fast rises in the prevalence of human taeniosis and porcine cysticercosis once the control programmes end (Gonzalez et al 2002; Kyvsgaard et al 2007). …”

Section: Discussionmentioning

confidence: 99%

Are we ready for Taenia solium cysticercosis elimination in sub-Saharan Africa?

et al. 2016

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SUMMARYThe World Health Organization announced in November 2014 at the fourth international meeting on ‘the control of neglected zoonotic diseases – from advocacy to action’, that intervention tools for eliminating Taenia solium taeniosis/cysticercosis (TSTC) are in place. The aim of this work was to elucidate theoretical outcomes of various control options suggested for TSTC elimination in sub-Saharan Africa (SSA) over a 4-year period. Our current knowledge regarding T. solium epidemiology and control primarily builds on studies from Latin America. A simple transmission model – built on data from Latin America – has been used to predict the effect of various interventions such as mass treatment of humans, vaccination and treatment of pigs, and health education of communities, potentially leading to change in bad practices and reducing transmission risks. Based on simulations of the transmission model, even a 4-year integrated One Health approach fails to eliminate TSTC from a small community and in all simulations, the prevalence of human taeniosis and porcine cysticercosis start to rise as soon as the programmes end. Our current knowledge regarding transmission and burden of TSTC in SSA is scarce and while claiming to be tool ready, the selection of diagnostic and surveillance tools, as well as the algorithms and stepwise approaches for control and elimination of TSTC remain major challenges.

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Section: Discussionmentioning

confidence: 99%

Are we ready for Taenia solium cysticercosis elimination in sub-Saharan Africa?

et al. 2016

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“…Both the options of mass therapy or screening for taeniasis would have to be conducted repeatedly to eradicate cysticercosis. As the coverage of either mass therapy or screening is unlikely to be 100%, more than 11 rounds of intervention may be required at a frequency of 90 days (Gonzalez et al. 2002).…”

Section: Discussionmentioning

confidence: 99%

Economic implications of three strategies for the control of taeniasis

Alexander

John

Jayaraman

et al. 2011

Tropical Med Int Health

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Summaryobjective To evaluate the cost-effectiveness of three strategies for the control of taeniasis in a community, in terms of cost per case treated.methods A study was conducted in South India to determine the prevalence of taeniasis by screening stool samples from 653 randomly chosen subjects, for coproantigens. The costs incurred in the project were used to estimate the cost per case screened and treated. A one-way sensitivity analysis was carried out for varying rates of taeniasis, different screening strategies and mass therapy. Further sensitivity analysis was carried out with different manpower and test costs.results The rate of taeniasis as detected by ELISA for coproantigen was 3 per 1000 (2 of 653 samples). Our study showed that mass therapy without screening for taeniasis would be the most economical strategy in terms of cost per case treated if field workers are employed exclusively for either mass therapy or screening. For each strategy, costs per case treated are higher at low prevalence of taeniasis, with a sharp rise below 15%.conclusions In places that are endemic for taeniasis and neurocysticercosis, mass therapy or screening for taeniasis should be considered. Screening by stool microscopy is not cost-effective in terms of cost per case of taeniasis treated owing to its low sensitivity. Although the cost per case of taeniasis treated is high at low prevalence of taeniasis for all options, incorporating mass therapy into existing mass drug distribution programmes might prove to be the most cost-effective control strategy.

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“…Supplementing human mass chemotherapy with mass anticysticercal treatment of swine reduced the need for human therapy when the swine received two treatments [49].…”

Section: Preventionmentioning

confidence: 99%

Neurocysticercosis: Current knowledge and advances

Shandera¹,

Kass²

2006

Curr Neurol Neurosci Rep

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Neurocysticercosis is the most common cause of acquired seizures worldwide. Most cases of this larval stage infection of the pork tapeworm Taenia solium occur in the developing world, although increasing numbers of cases are being recognized in the United States, particularly among Hispanic immigrants. The ability of the pathogen to persist for years within the host is the subject of immunologic and biochemical investigation. The major presenting symptom is seizures, although symptoms of obstructive hydrocephalus occur if cysts are located near the ventricles or in the subarachnoid spaces. Diagnosis is dependent on clinical, radiologic, and serologic data. Therapy with antiparasitic agents, especially albendazole, is effective in large burden disease or disease within sensitive neuraxis sites (the ventricles, the subarachnoid spaces). When patients with radiologically enhancing disease are given cysticidal therapy, there appears to be a reduction in seizure recurrences. Surgery is indicated for disease in selected anatomic sites. Long-term prevention requires attention to pork husbandry and general sanitation, including the potential use of mass human chemotherapy and porcine vaccination.

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Use of a simulation model to evaluate control programmes against Taenia solium cysticercosis.

Cited by 19 publications

References 0 publications

Are we ready for Taenia solium cysticercosis elimination in sub-Saharan Africa?

Are we ready for Taenia solium cysticercosis elimination in sub-Saharan Africa?

Economic implications of three strategies for the control of taeniasis

Neurocysticercosis: Current knowledge and advances

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