Use of a specific anti‐stretch mark cream for preventing or reducing the severity of striae gravidarum. Randomized, double‐blind, controlled trial

Abstract

Few studies have tested the efficacy of commercially available cosmetic products for preventing striae gravidarum. Therefore, the objective of this study was to evaluate efficacy on prevention of striae gravidarum using a specific anti-stretch mark cream containing hydroxyprolisilane-C, rosehip oil, Centella asiatica triterpenes and vitamin E. A randomized, double-blind, placebo-controlled trial was conducted between November 2009 and April 2011. Pregnant women were included and classified as treated group (emollient and moisturizer containing hydroxyprolisilane C, rosehip oil, Centella asiatica triterpenes and vitamin E) and control group (cream without the active ingredients). Overall incidence of stretch marks during pregnancy was 33.3% for the control group and 37.6% for the treated group (n.s.). Severity of previous stretch marks significantly increased in the control group during the study (17.8%, P = 0.001), but not in the treated group (6.3%, ns). In women who developed new stretch marks during the study, there was a significantly greater 'difference in severity' (between baseline and maximum severity) in control group vs. treated group (0.47 [0.57] vs. 0.14 [0.60], P = 0.031). In women without previous striae, incidence of these marks was significantly lower for the treated group patients compared with control group (5.6% vs. 35%, P = 0.031, OR: 9.2 [95% CI: 1.0-83.3]). The use of the anti-stretch mark product is proved to be effective in reducing severity of the striae during pregnancy, prevents the appearance of new striae and halts progression of those already present. In women who had no striae at baseline, use of the anti-stretch mark cream was more effective than placebo in preventing new stretch marks.

Striae gravidarum: Risk factors, prevention, and management

“…Creams that contain Centella asiatica extract, especially Trofolastin cream, are best supported by data for the prevention or reduction of the severity of SG (Table 2; García Hernández et al, 2013, Mallol et al, 1991). Centella asiatica is a medicinal herb that is thought to increase the production of collagen and elastic fibers (García Hernández et al, 2013).…”

“…Creams that contain Centella asiatica extract, especially Trofolastin cream, are best supported by data for the prevention or reduction of the severity of SG (Table 2; García Hernández et al, 2013, Mallol et al, 1991). Centella asiatica is a medicinal herb that is thought to increase the production of collagen and elastic fibers (García Hernández et al, 2013). Mallol et al (1991) demonstrated that Trofolastin cream with Centella asiatica extract, α-tocopherol, and collagen–elastin hydrolysates that is applied daily from gestational week 12 until delivery significantly reduced the incidence of SG compared with placebo.…”

“…Mallol et al (1991) demonstrated that Trofolastin cream with Centella asiatica extract, α-tocopherol, and collagen–elastin hydrolysates that is applied daily from gestational week 12 until delivery significantly reduced the incidence of SG compared with placebo. Both Mallol et al (1991) and García Hernández et al (2013) found that creams that contained Centella asiatica significantly reduced the intensity and/or severity of SG among women who did develop SG. García Hernández et al (2013) also demonstrated that the severity of previous striae significantly increased in the patient group treated with placebo but did not change in the patient group treated with Centella cream.…”

Natūralių Aliejų Ir Cheminių Preparatų, Naudojamų Strijų Prevencijai Nėštumo Metu, Efektyvumo Palyginimas

“…Saj (®) prevencinio kremo veiksmingumo tyrimas, 2014, [17] buvo normali, 13 -sausa, 6 -riebi, 15 -mišri. Moterys, kurioms būdinga riebi ir natūrali oda, strijų profilaktikai dažniau vartojo cheminius preparatus, o turinčios sausą ir mišrią odą pirmenybę atidavė natūraliems aliejams (1 pav).…”

Determination of complementary therapies for prevention of striae gravidarum

“…Ülkemizde yürütülen bu üç çalışmanın aksine García Hernández ve ark. 10 , krem kullanımının yeni SG oluşumunu engellediğini ve mevcut SG'nin şiddetini azalttığını belirtmiştir. Bu çalışmanın primer amacı kadınların SG'yi önlemek için kullandıkları tamamlayıcı terapileri belirlemek ve etkinliğini incelemek, sekonder amacı ise SG oluşumunda etkili olabilecek risk faktörlerini ortaya koymaktır.…”