Non-invasive mechanical ventilation using bilevel positive airway pressure provides cycles of pressure-support ventilation in the inspiratory phase and positive end-expiratory pressure in the expiratory phase. Bilevel positive airway pressure has emerged as an alternative to endotracheal intubation and mechanical ventilation in primary pulmonary disorders. 1 Concern about the morbidity of mechanical ventilation has resulted in increased use of BiPAP. In acute neurologic diseases, BiPAP can provide ventilatory assistance in myasthenic crises while awaiting the effect of plasma exchange. 2 Nasal mask continuous positive air pressure has been used in patients with bilateral diaphragmatic paralysis after heart surgery and one successful attempt to prevent intubation is on record in GuillainBarré syndrome. 3,4 Neuromuscular respiratory failure is present in 30% of patients with Guillain-Barré syndrome. In patients with marginal respiratory function who are not necessarily candidates for immediate intubation, BiPAP could theoretically be a useful, temporary assisting device. The decreased workload of breathing leads not only to marked improvement in patient comfort but also to improved gas exchange. We have recently used BiPAP in two patients with Guillain-Barré syndrome but report its failure, and worse, emergency intubation in both of these patients.
ABSTRACT:Background: Non-invasive mechanical ventilation (BiPAP) has been introduced for use in neuromuscular respiratory disease such as amyotrophic lateral sclerosis and myasthenia gravis. There is no experience in Guillain-Barré syndrome. Methods: We describe for the first time the use of BiPAP to assist in the work of breathing in two consecutive patients with progressing Guillain-Barré syndrome (GBS) and marginal pulmonary function. Results: Our initial attempts to use BiPAP in GBS and early neuromuscular respiratory failure were totally unsuccessful. There was marked initial improvement; however, emergency intubation was needed in both patients, one of which became acutely cyanotic. Conclusions: Until more experience is available, we strongly warn against using BiPAP in deteriorating patients with GBS.RÉSUMÉ: Le système BiPAP peut échouer dans le syndrome de Guillain-Barré en phase précoce. Contexte: La ventilation mécanique non effractive (BiPAP) est utilisée dans les maladies neuromusculaires avec atteinte respiratoire comme la sclérose latérale amyotrophique et la myasthénie grave. Cependant, il n'y a pas de données sur le syndrome de Guillain-Barré (SGB). Méthodes: Nous décrivons pour la première fois l'utilisation du BiPAP pour fournir une assistance respiratoire chez deux patients consécutifs présentant un (SGB) évolutif et une fonction pulmonaire limite. Résultats: Nos premières tentatives d'utilisation du BiPAP dans le SGB avec insuffisance respiratoire neuromusculaire au début se sont soldées par un échec. L'amélioration initiale était importante, cependant une intubation d'urgence s'est avérée nécessaire chez les deux patients, dont un est devenu subitem...