The radionuclides presently available for bone imaging include Sr8'"', Srs5, and F18. With any of these, the entire skeleton can be surveyed for localized bone disease by profile scanning, whole body counting, rectilinear scanning, or with the Mark I1 whole body scanner and positron scintillation camera. Whole body counting and profile scanning rapidly eliminate normal areas and focus attention on suspicious sites which must then be studied with a conventional scanner. RectiIinear scanning requires considerable time. The Mark I1 whole body scanner can survey the skeleton rapidly but not so accurately as the positron scintillation camera. The positron camera is accurate but slow. The ideal method for accurately and rapidly surveying the entire skeleton would utilize F'" as the radioactive agent and a large-crystal positron scintillation camera as the imaging device.