Use of a γ-labeled bile acid (75SeHCAT) as a test of ileal function

Ferraris, R.; Jazrawi, R. P.; Bridges, C.; Northfield, T. C.

doi:10.1016/0016-5085(86)90377-x

Cited by 32 publications

(11 citation statements)

References 10 publications

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“…The 75 SeHCAT results were quite stable in the diarrhoea patients: median value of 18% (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23) in the first test versus 14% (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21) in the second test (n = 39, P = 0.37). The median time interval between the two tests was 44 months .…”

Section: Repeated Measures Of 75 Sehcat Retentionmentioning

confidence: 72%

“…The values of the test were highly stable in patients with chronic diarrhoea after a mean time of 4 years. Since the 75 SeHCAT is absorbed almost solely by the active transport system in the terminal ileum [20,21], the high concordance between the two tests suggests that this transport system is very stable in patients with chronic diarrhoea.…”

Section: Discussionmentioning

confidence: 93%

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The Bile Acid Turnover Rate Assessed with the 75SeHCAT Test Is Stable in Chronic Diarrhoea but Slightly Decreased in Healthy Subjects After a Long Period of Time

et al. 2008

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The stability of bile acid turnover rate was evaluated retrospectively using repeat SeHCAT tests in patients with chronic diarrhoea and prospectively for 16 years in healthy subjects. The SeHCAT values were stable in 39 patients with chronic diarrhoea, as shown by a comparison of the test results [data presented as median and (25th-75th percentile)]: 18% (8-23) in the first test versus 14% (9-21) in the second test [n = 39, P = 0.37, time interval 44 months (16-68), repeatability index >95%]. In contrast, they were reduced after 16 years in healthy subjects: 38% (30-49.5) in the first test versus 31% (21-49.5) in the second test (P < 0.03). In healthy subjects, the body mass index increased by 13% from 23.2 kg/m(2) (21-24.6) to 26.2 kg/m(2) (22.5-27.8) (P < 0.01) during the 16 years. There was a negative correlation between hepatic bile acid synthesis and the SeHCAT values (r = -0.615, P = 0.02, n = 14). In conclusion, the turnover rate of bile acids is stable over a long period of time in patients with chronic diarrhoea irrespective of bile acid malabsorption, suggesting that a repeat SeHCAT test is dispensable. There is a significant negative correlation between bile acid synthesis and SeHCAT test results in healthy subjects. The SeHCAT test values are slightly reduced in healthy subjects after 16 years.

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Section: Repeated Measures Of 75 Sehcat Retentionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 93%

The Bile Acid Turnover Rate Assessed with the 75SeHCAT Test Is Stable in Chronic Diarrhoea but Slightly Decreased in Healthy Subjects After a Long Period of Time

et al. 2008

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“…The 75 SeHCAT test was performed as previously described,3 16 assessing the exponential decrease of radioactivity over the gall bladder area by collimated gammacamera for seven consecutive days 3. Bile acid malabsorption was diagnosed when 75 SeHCAT half life was less than two days 16…”

Section: Methodsmentioning

confidence: 99%

Biliary lipid composition in idiopathic bile acid malabsorption

Fracchia¹,

Pellegrino²,

Secreto³

et al. 1998

Gut

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Background-Chronic diarrhoea is the clinical hallmark of patients presenting with idiopathic bile acid malabsorption. Its pathogenesis is unknown; colonic water secretion can be induced by dihydroxy bile acids, but it is not known whether enrichment of the bile acid pool with these bile acids occurs in such patients. Furthermore, bile acid malabsorption is known to aVect biliary lipid composition, but no information is available for the idiopathic type. (Gut 1998;43:812-816) Aims-To

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“…The retention halve life is the discriminating parameter. Alternatively the counting of radioactive Se can be performed in stool samples collected over a number of days [88].…”

Section: Bile Acid Kineticsmentioning

confidence: 99%

Assessment of Modes of Action and Efficacy of Plasma Cholesterol- Lowering Drugs: Measurement of Cholesterol Absorption, Cholesterol Synthesis and Bile Acid Synthesis and Turnover Using Novel Stable Isotope Techniques

Stellaard¹,

Kuipers

2005

curr drug targets immune endocr metabol disord

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Several processes are involved in control of plasma cholesterol levels, e.g., intestinal cholesterol absorption, endogenous cholesterol synthesis and transport and bile acid synthesis. Adaptation of either of these processes allows the body to adapt to changes in dietary cholesterol intake. Disturbances herein may lead to hypercholesterolemia and increase the risk for atherosclerosis. Several approaches are available for plasma-cholesterol lowering therapies, particularly aimed at reduction of low-density lipoprotein (LDL) cholesterol. Currently used therapies aim to decrease (hepatic) cholesterol synthesis, to inhibit cholesterol absorption or to stimulate bile acid synthesis. The latter can be achieved by reducing bile acid absorption to alleviate the negative feedback control exerted by bile acids circulating in the body. Approaches to directly stimulate bile acid synthesis may become available. Novel drugs should be tested on the efficiency to influence their actual targets. Several techniques are available to measure cholesterol absorption, cholesterol synthesis and bile acid synthesis and absorption in vivo in human subjects. The most reliable techniques are based on the use of stable isotopes and mass spectrometry. This paper provides a condensed background on physiological parameters that determine cholesterol homeostasis, and potential new mechanisms of drug action and focuses, especially, on new techniques to monitor the effects of drugs in humans.

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Use of a γ-labeled bile acid (75SeHCAT) as a test of ileal function

Cited by 32 publications

References 10 publications

The Bile Acid Turnover Rate Assessed with the 75SeHCAT Test Is Stable in Chronic Diarrhoea but Slightly Decreased in Healthy Subjects After a Long Period of Time

The Bile Acid Turnover Rate Assessed with the 75SeHCAT Test Is Stable in Chronic Diarrhoea but Slightly Decreased in Healthy Subjects After a Long Period of Time

Biliary lipid composition in idiopathic bile acid malabsorption

Assessment of Modes of Action and Efficacy of Plasma Cholesterol- Lowering Drugs: Measurement of Cholesterol Absorption, Cholesterol Synthesis and Bile Acid Synthesis and Turnover Using Novel Stable Isotope Techniques

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