Use of aglepristone for the treatment of P<sub>4</sub>induced insulin resistance in dogs

Bigliardi, Enrico; Bresciani, Carla; Callegari, Donatella; Ianni, Francesco Di; Morini, G.; Parmigiani, Enrico; Bianchi, Ezio

doi:10.4142/jvs.2014.15.2.267

Cited by 14 publications

(13 citation statements)

References 20 publications

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“…In the second case, aglépristone, a competitive progesterone receptor antagonist was used, in order to facilitate stabilization of the diabetic condition before anaesthesia and surgery [22]. Aglépristone can reduce progesterone and GH concentration within days but better glycaemic control was observed in one study 12 days post aglépristone administration [3] [4]. None of the dogs in that study entered diabetic remission [4].…”

Section: Discussionmentioning

confidence: 99%

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Clinical diabetes mellitus in association with diestrus-induced acromegaly in 2 bitches

Bauer

Hausmann³

et al. 2019

Tierarztl Prax Ausg K

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Two intact bitches aged 9 and 11 years were referred due to chronic polyuria, polydipsia, vomiting, anorexia and progressive lethargy. On clinical examination, signs of tissue overgrowth (large paws, widened interdental space, pharyngeal stridor) were noticed. Diabetes mellitus (DM) was diagnosed in one dog (case 1) and diabetic ketoacidosis (DKA) in the other (case 2). There were increased IGF-1 values suggestive of hypersomatotropism. Progesterone values and pathological findings of the ovaries and uterus indicated diestrus. Diagnosis of diestrus-induced hypersomatotropism was made and ovariohysterectomy was performed in both dogs. Dog 1 also had multiple mammary neoplasms treated with bilateral mastectomy. Treatment resulted in diabetic remission in case 1 and improved glycaemic control in case 2. Overall, diestrus-induced hypersomatotropism is rare but should be considered in any intact diabetic bitch with acromegalic features. Ovariohysterectomy is recommended and associated with a fair to good prognosis.

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Section: Discussionmentioning

confidence: 99%

“…Therefore, despite the negative culture result, marbofloxacin was continued for a total of 2 weeks as a part of post-operative care. To suppress the progesterone influence, aglépristone (Alizin ® , Virbac, France) was administered twice at a dose of 10 mg/kg s. c. 24 hours apart [4].…”

Section: Treatmentmentioning

confidence: 99%

Clinical diabetes mellitus in association with diestrus-induced acromegaly in 2 bitches

Bauer

Hausmann³

et al. 2019

Tierarztl Prax Ausg K

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“…In the bitch, degenerative diseases of the uterus, such as cystic hyperplasia‐pyometra (CHE) complex and metabolic alterations that may result, that is insulin resistance (Bigliardi et al., ), are frequent. The cystic endometrial hyperplasia in the bitch is a multifactorial disease that compromises fertility and may evolve into infectious form with severe effects for the health of the animal.…”

Section: Discussionmentioning

confidence: 99%

“…In the bitch, degenerative diseases of the uterus, such as cystic hyperplasia-pyometra (CHE) complex and metabolic alterations that may result, that is insulin resistance (Bigliardi et al, 2014), are (Linnea, Bodil, & Ragnvi, 2014). Between the main aetiological factors, it has been amply demonstrated the role of exogenous progesterone, growth hormone (GH) and some somatomedins (Bigliardi et al, 2004;De Bosschere, Ducatelle, Vermeirsch, Van Den Broeck, & Coryn, 2001) although the disease was also observed in patients which never received exogenous progestin.…”

Section: Discussionmentioning

confidence: 99%

Isolation, proliferation and characterization of endometrial canine stem cells

Cesaris

Grolli

Bresciani

et al. 2016

Reprod Domestic Animals

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In the last decade, progenitor cells isolated from dissociated endometrial tissue have been the subject of many studies in several animal species. Recently, endometrial cells showing characteristics of mesenchymal stem cells (MSC) have been demonstrated in human, pig and cow uterine tissue samples. The aim of this study was the isolation and characterization of stromal cells from the endometrium of healthy bitches, a tissue that after elective surgery is routinely discarded. Multipotent stromal cells could be isolated from all bitches enrolled in the study (n = 7). The multipotency of cells was demonstrated by their capacity to differentiate into adipocytic, osteocytic and chondrocytic lineages. Clonogenicity and cell proliferation ability were also tested. Furthermore, gene expression analysis by RT-PCR was used to compare the expression of a set of genes (CD44, CD29, CD34, CD45, CD90, CD13, CD133, CD73, CD31 CD105, Oct4) with adipose tissue-derived MSC. Stromal cells isolated from uterine endometrium showed similar morphology, ability of subculture and plasticity, and also expressed a panel of genes comparable with adipose tissue-derived MSC. These data suggest that endometrial stromal cells fulfil the basic criteria proposed by the "Mesenchymal and Tissue Stem Cell Committee of the International Society for Cellular Therapy" for the identification of mesenchymal stem cells. Although endometrial mesenchymal stem cells (EnMSC) showed a lower replicative ability in comparison with adipose tissue-derived MSC, they could be considered a cell therapeutic agent alternative to adipose tissue or bone marrow-derived MSC in dog.

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“…Ovariectomy and ovariohysterectomy are the most common surgical procedures used to sterilize female dogs. Prophylactic gastropexy and ovariectomy or ovariohysterectomy are routinely performed in small animal practice . Prophylactic gastropexy prevents gastric‐dilatation volvulus in predisposed dogs .…”

Section: Introductionmentioning

confidence: 99%

Meloxicam vs robenacoxib for postoperative pain management in dogs undergoing combined laparoscopic ovariectomy and laparoscopic‐assisted gastropexy

Bendinelli¹,

Properzi²,

Boschi³

et al. 2019

Veterinary Surgery

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Objective: To compare meloxicam and robenacoxib for short-term postoperative pain management after combined laparoscopic ovariectomy and laparoscopicassisted gastropexy. Study design: Double-blind, prospective, randomised clinical trial. Animals: Twenty-six client-owned female dogs. Methods: Dogs undergoing combined laparoscopic ovariectomy and laparoscopicassisted gastropexy were randomly divided into 2 groups. Before induction of anesthesia, 13 dogs received meloxicam (0.2 mg/kg subcutaneously), and 13 dogs received robenacoxib (2 mg/kg subcutaneously). Pain was scored with the Glasgow Composite Pain Scale (short form) before surgery and at 1, 6, 12, 18, and 24 hours after extubation. Rescue analgesia (tramadol, 3 mg/kg) was provided to dogs with a Glasgow pain score (GPS) ≥5. Glasgow pain scores were analyzed by ANOVA with treatment, age, and surgical time as fixed factors. Results: Glasgow pain scores were higher at 24 hours postsurgery in dogs treated with robenacoxib (2.18 ± 0.29) compared with those treated with meloxicam (0.68 ± 0.41, P = .04). Two dogs treated with meloxicam and 7 dogs treated with robenacoxib required rescue analgesia. Regardless of the treatment, the overall GPS was lower at 18 and 24 hours postsurgery when the surgical time was >40 minutes compared with surgical times ≤40 minutes, but surgical site inflammation was likely a confounding factor in this finding. Glasgow pain score was not affected by patient age. Conclusion: Meloxicam was more effective than robenacoxib at controlling pain in the population of dogs reported here. Clinical significance: Preoperative administration of meloxicam effectively controls pain for 24 hours after combined laparoscopic ovariectomy and laparoscopicassisted gastropexy, but rescue analgesia may be required.

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Use of aglepristone for the treatment of P₄induced insulin resistance in dogs

Cited by 14 publications

References 20 publications

Clinical diabetes mellitus in association with diestrus-induced acromegaly in 2 bitches

Clinical diabetes mellitus in association with diestrus-induced acromegaly in 2 bitches

Isolation, proliferation and characterization of endometrial canine stem cells

Meloxicam vs robenacoxib for postoperative pain management in dogs undergoing combined laparoscopic ovariectomy and laparoscopic‐assisted gastropexy

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Use of aglepristone for the treatment of P4induced insulin resistance in dogs

Cited by 14 publications

References 20 publications

Clinical diabetes mellitus in association with diestrus-induced acromegaly in 2 bitches

Clinical diabetes mellitus in association with diestrus-induced acromegaly in 2 bitches

Isolation, proliferation and characterization of endometrial canine stem cells

Meloxicam vs robenacoxib for postoperative pain management in dogs undergoing combined laparoscopic ovariectomy and laparoscopic‐assisted gastropexy

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Product

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Use of aglepristone for the treatment of P₄induced insulin resistance in dogs