Serum albumin is widely used for the treatment of hypovolemia, shock, hyperbilirubinemia or acute liver failure. However, serum albumin itself may have a signicant eect on the action, elimination or distribution of other medica tions in blood which may aect the outcome of the treatment. Besides, it is also expensive and, most important, can be a carrier for many lifethreatening diseases such as AIDS. The objective of this study is to evaluate the serum albumin utilization in inpatient at a private hospital in Bangkok, Thailand. Descriptive, retrospective study was designed to mo nitor the 25 w/v serum albumin orders over a fourmonth period. The background information, doses and rational of serum albumin orders, other medication orders, side eects, the interaction between serum albumin and other medica tions, the laboratory results and also clinical outcome of the patients were recorded. From the medication orders of 74 inpatients, there were 104 orders of serum albumin for 9 indications. The most common indications were hypoalbumine mia (48) and cirrhosis (9). From the total number of serum albumin orders, there were only 67 orders (64.4) prescribed with rational dose and duration under appropriate indications. Totally about 35.6 of serum albumin orders were prescribed with improper indications such as edema, anemia or coronary artery bypass grafting. Out of 35.6, 14 of the orders were prescribed to contraindicated patients. No side eect of serum albumin infusion was found during this study. The result indicates the overutilization of serum albumin and specic guideline for using this agent should be set in every hospital.