“…140,428,493,494,655,657,694,698,699,701,705,[707][708][709][710][715][716][717][718]728,853 In general, most studies differed greatly in their duration and intervention approach. Moreover, the outcome measure of hand hygiene compliance varied in terms of the definition of a hand hygiene opportunity and assessment of hand hygiene by means of direct observation 60,217,334,485,486,494,572,613,645,651,657,663,666,667,670,680,682,686,687,701,716 or consumption of hand hygiene products, 60,334,429,486,494,71 3,717,718,803,804,851 making comparison difficult, if not impossible. Despite different methodologies, most interventions have been associated with an increase in hand hygiene compliance, but a sustainable improvement demonstrated by a followup evaluation of two years or more after implementation has rarely been documented.…”