Use of allicin as feed additive to enhance vaccination capacity of Clostridium perfringens toxoid in rabbits

Hammed, Waleed Abu El; Soufy, Hamdy; EL-Shemy, Ahmed; Nasr, Soad M.; Dessouky, Mohamed I.

doi:10.1016/j.vaccine.2016.02.073

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…The reduction in enzyme activity reflected impact of both allicin administrations on liver function. Treatment with allicin showed marked reductions in serum activity of ALT and ALP in infected rabbits, confirming the antibacterial activity of allicin that reduced the damaging effects of bacteria on the liver (Abu El Hammed, Soufy, El‐Shemy, Nasr, & Dessouky, ). In addition, aqueous garlic extract improved hepatic steatosis in rabbits (Arhan et al, ) and this effect was attributed to the organo‐sulphur compounds (allicin) present in garlic.…”

Section: Discussionmentioning

confidence: 58%

Influence of allicin administration on reproductive efficiency, immunity and lipid peroxidation of rabbit does under high ambient temperature

El‐Ratel

Abdel‐Khalek

Gabr

et al. 2020

Animal Physiology Nutrition

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This study investigated the effect of daily oral administration with allicin levels (0, 5 and 10 mg/kg of female body weight), 30 days pre‐insemination, on reproductive performance in vivo and in vitro, immunity, and oxidative stress of rabbit does under high ambient temperature. Niliparous NZW does (n = 105) were randomly divided into three groups (35 in each) treated with 0, 5 and 10 mg allicin dissolved in 2 ml distilled water, respectively, for 30 days pre‐insemination. At the end of treatment (30 days), does were artificially inseminated with fresh diluted semen of 20 fertile NZW bucks. Reproductive performance and ovulatory response parameters were determined. Serum biochemicals, enzyme activity, immunoglobulins (IgG and IgM) and antioxidant status were determined on day 30 of treatment. Serum progesterone and prolactin were determined pre‐insemination (30 days of treatment), on 15 days of pregnancy and 7 days post‐partum. Results showed that both allicin levels increased live litter size, and bunny viability rat and litter size at birth and weaning. Allicin levels increased ovulation rate and improved embryo quality. Number of total follicles decreased only with 10 mg allicin. Progesterone increased pre‐insemination, 15 days of pregnancy and 7 days post‐partum progesterone by allicin levels. Prolactin pre‐insemination and on day 7 post‐partum increased with 10 mg allicin. Serum total proteins, albumin, globulin, IgG and IgM increased, while glucose, aspartate and alanine aminotransaminases, and thiobarbituric acid reaction decreased by both allicin levels. In conclusion, the mechanism by which allicin administration 30 days pre‐insemination to improve the reproductive performance of rabbit does is based on that allicin can play an important role, as a natural exogenous antioxidant, increasing immune response and reducing lipid peroxidation.

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Section: Discussionmentioning

confidence: 58%

Influence of allicin administration on reproductive efficiency, immunity and lipid peroxidation of rabbit does under high ambient temperature

El‐Ratel

Abdel‐Khalek

Gabr

et al. 2020

Animal Physiology Nutrition

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“…Regarding enzyme activities and liver functions, ALT, ALP, LDH, and bilirubin showed significant elevations in Pasteurella -infected rabbits, possibly related to injury and degeneration of hepatocytes [ 61 – 63 ]. However, infected rabbits, treated with allicin and/or norfloxacin, showed marked reductions in serum ALT, ALP, LDH, and bilirubin levels, confirming the antibacterial activity of allicin and norfloxacin that reduced the damaging effects of bacteria on the liver [ 64 ].…”

Section: Discussionmentioning

confidence: 92%

Anti‐Inflammatory, Immunomodulatory, and Antioxidant Activities of Allicin, Norfloxacin, or Their Combination against Pasteurella multocida Infection in Male New Zealand Rabbits

Alam

Fawzi

Alkhalf

et al. 2018

Oxidative Medicine and Cellular Longevity

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The present study investigated the efficacy of allicin as an antibacterial, anti-inflammatory, antioxidant, and immunostimulant agent in reducing the severity of Pasteurella multocida (P. multocida) type B infection in rabbits. Fifty New Zealand rabbits, 5 weeks old, were divided equally into five groups. Except for group 1, all groups were intranasally infected with P. multocida type B (2 × 105 colony forming units/ml/rabbit). Then, group 3 rabbits were orally treated with allicin (50 mg/kg BW) for 5 days, group 4 rabbits received a single oral dose of norfloxacin 30% (100 mg/kg BW), while group 5 rabbits were treated with a combination of norfloxacin and allicin. Hematological, serum biochemical, inflammatory cytokine, immunological, and histopathological analyses were performed. Results revealed that rabbits, infected with P. multocida type B, exhibited macrocytic hypochromic anemia and leukocytosis with a significant elevation in the phagocytic percentage and index. Moreover, significant reductions in serum total protein, albumin, globulin, and immunoglobulin (IgG and IgM) levels were observed in infected rabbits. Infected rabbits showed significant increases in serum inflammatory cytokine (TNF-α and IL-6), alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, and serum bilirubin (total, direct, and indirect) levels. Further, P. multocida infection induced oxidative stress as demonstrated by the significant reduction in serum levels of reduced glutathione and superoxide dismutase enzyme and marked elevation in serum malondialdehyde. Treatment with allicin, norfloxacin, or their combination significantly ameliorated the alterations in all studied parameters. In conclusion, allicin could ameliorate the inflammation and oxidative stress, induced by P. multocida type B infection in rabbits.

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Uses and Regulatory Guidelines for Nutraceuticals in China

Sun

Zhong-qi

Feng³

et al. 2019

Nutraceuticals in Veterinary Medicine

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Use of allicin as feed additive to enhance vaccination capacity of Clostridium perfringens toxoid in rabbits

Cited by 4 publications

References 30 publications

Influence of allicin administration on reproductive efficiency, immunity and lipid peroxidation of rabbit does under high ambient temperature

Influence of allicin administration on reproductive efficiency, immunity and lipid peroxidation of rabbit does under high ambient temperature

Anti‐Inflammatory, Immunomodulatory, and Antioxidant Activities of Allicin, Norfloxacin, or Their Combination against Pasteurella multocida Infection in Male New Zealand Rabbits

Uses and Regulatory Guidelines for Nutraceuticals in China

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