Use of an Acellular Regenerative Tissue Matrix in Combination with Vacuum-assisted Closure Therapy for Treatment of a Diabetic Foot Wound

Randall, Kyle; Booth, Branyan A.; Miller, Adrian J.; Russell, Corey B.; Laughlin, Richard T.

doi:10.1053/j.jfas.2008.04.012

Cited by 15 publications

(9 citation statements)

References 10 publications

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“…ADMs have been commonly used for treatment of acute and chronic wounds. Non-healing, diabetic ulcers of the lower extremities, particularly the foot, can be treated with an ADM to achieve complete healing and integration while avoiding second site morbidity associated with autografts (Winters et al 2008 ; Randall et al 2008 ). Yonehiro et al ( 2013 ) successfully treated diabetic foot ulcers using MH-ADM with a substantial wound healing rate of 83 % in their evaluation of 11 patients with 12 non-healing diabetic ulcers.…”

Section: Clinical Applications Of Mh-admmentioning

confidence: 99%

“…In addition, human ADM is commonly used for soft tissue reconstruction procedures including primary, staged, and revision breast reconstruction (Sbitany et al 2009 ; Nahabedian 2009 ; Salzberg 2006 ) and hernia repair (Kapfer and Keshen 2006 ; Albo et al 2006 ; Candage et al 2008 ; Mitchell and Cima 2011 ). Moreover, human ADM is widely used in the treatment of chronic wounds such as diabetic foot ulcers (Winters et al 2008 ; Randall et al 2008 ; Brigido et al 2004 ).…”

Section: Introductionmentioning

confidence: 99%

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Decellularization of human dermis using non-denaturing anionic detergent and endonuclease: a review

et al. 2014

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Decellularized human dermis has been used for a number of clinical applications including wound healing, soft tissue reconstruction, and sports medicine procedures. A variety of methods exist to prepare this useful class of biomaterial. Here, we describe a decellularization technology (MatrACELL®) utilizing a non-denaturing anionic detergent, N-Lauroyl sarcosinate, and endonuclease, which was developed to remove potentially immunogenic material while retaining biomechanical properties. Effective decellularization was demonstrated by a residual DNA content of ≤4 ng/mg of wet weight which represented >97 % DNA removal compared to unprocessed dermis. Two millimeter thick MatrACELL processed human acellular dermal matrix (MH-ADM) exhibited average ultimate tensile load to failure of 635.4 ± 199.9 N and average suture retention strength of 134.9 ± 55.1 N. Using an in vivo mouse skin excisional model, MH-ADM was shown to be biocompatible and capable of supporting cellular and vascular in-growth. Finally, clinical studies of MH-ADM in variety of applications suggest it can be an appropriate scaffold for wound healing, soft tissue reconstruction, and soft tissue augmentation.

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Section: Clinical Applications Of Mh-admmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Decellularization of human dermis using non-denaturing anionic detergent and endonuclease: a review

et al. 2014

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“…The other 2 Advances in Orthopedic Surgery major category of biological scaffold augment material is decellularized human skin allografts which made up slightly more than half of the augmented repair market in 2010 and this number is expected to increase [1] as surgeons choose allografts over both xenografts and nonaugmented repairs. Decellularized human skin allografts have been used for a variety of medical procedures, primarily wound healing, soft tissue reconstruction, and sports medicine applications [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. In theory, decellularization serves to remove potentially immunogenic material and also provides a clean scaffold for host cellular and vascular ingrowth [25].…”

Section: Introductionmentioning

confidence: 99%

A Simplified Approach for Arthroscopic Repair of Rotator Cuff Tear with Dermal Patch Augmentation

Levenda¹,

Sanders²

2015

Advances in Orthopedic Surgery

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Here, we describe an arthroscopic method specifically developed to augment rotator cuff repair using a flexible acellular dermal patch (ADP). In this method, an apparently complex technique is simplified by utilizing specific steps to augment a rotator cuff repair. In this method, using a revised arthroscopic technique, rotator cuff repair was performed. This technique allowed easy passage of the graft, excellent visualization, minimal soft tissue trauma, and full four-corner fixation of an ADP. Twelve patients underwent rotator cuff repair with augmentation using the combination of this method and ADP. Due to the technique and biomechanical characteristics of the material, the repairs have been stable and with high patient satisfaction.

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“…[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Certainly the introduction of advanced wound care technologies, including negative pressure wound therapy (NPWT) and bioengineered tissues such as acellular dermal matrices (ADMs), has reduced the need for complex surgical procedures with the right indication. [15][16][17][18][19][20][21][22][23][24] The use of an ADM underneath split thickness skin grafts (STSGs) provides an additional thick layer at the wound bed, promoting wound healing while providing vital tissue support for STSG, improving the mechanical and functional properties of coverage. [25][26][27][28][29] A 2-step procedure is the most common approach, where the coverage by a STSG is performed after the ADM is fully integrated.…”

Section: Introductionmentioning

confidence: 99%

A New Human-Derived Acellular Dermal Matrix for 1-Stage Coverage of Exposed Tendons in the Foot

Melandri

Marongiu

Carboni

et al. 2019

The International Journal of Lower Extremity Wounds

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The closure of wounds associated with soft tissue defects is surgically challenging, frequently requiring extensive plastic surgery and free flaps. The combination of ADM and STSG is an innovative method used to cover such wounds. The human-derived ADMs (H-ADMs) are the most described in the literature but according to European legislations, Companies H-ADMs outside the EC are not allowed to commercialize them in Europe, H-ADMs being “human products” and not “medical devices”, so being ruled by European legislations on transplants. The Skin Bank of the Bufalini Hospital (Cesena, Italy) obtained in 2009 the approval for the production and distribution of the first human cadaver-donor derived ADM from the Italian National Transplant Center and National Health Institute, we called with the Italian acronym M.O.D.A. (Matrice Omologa Dermica Acellulata). We present here the first use of a new H-ADM for treatment of distal lower extremity wounds with exposed tendons managed in one-stage pocedure with STSG. The excellent performance suggests that in cases where autologous tissue is unavailable or undesirable, the use of M.O.D.A. in one-stage procedure represents a promising alternative for covering wounds associated with tendons exposition.

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Use of an Acellular Regenerative Tissue Matrix in Combination with Vacuum-assisted Closure Therapy for Treatment of a Diabetic Foot Wound

Cited by 15 publications

References 10 publications

Decellularization of human dermis using non-denaturing anionic detergent and endonuclease: a review

Decellularization of human dermis using non-denaturing anionic detergent and endonuclease: a review

A Simplified Approach for Arthroscopic Repair of Rotator Cuff Tear with Dermal Patch Augmentation

A New Human-Derived Acellular Dermal Matrix for 1-Stage Coverage of Exposed Tendons in the Foot

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