Use of an ATP-supplemented medium for the conservation of human semen and the effect of caffeine on the motility of preserved sperm. Results in artificial insemination.

Díaz, Jorge Rosa; González, Marco Aurélio Stumpf; Avedo, F; Mallea, L; Rodríguez, Nathalie

doi:10.1111/j.1439-0272.1992.tb02625.x

Cited by 3 publications

References 12 publications

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Purinergic signalling in the reproductive system in health and disease

Burnstock

2013

Purinergic Signalling

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There are multiple roles for purinergic signalling in both male and female reproductive organs. ATP, released as a cotransmitter with noradrenaline from sympathetic nerves, contracts smooth muscle via P2X1 receptors in vas deferens, seminal vesicles, prostate and uterus, as well as in blood vessels. Male infertility occurs in P2X1 receptor knockout mice. Both short-and long-term trophic purinergic signalling occurs in reproductive organs. Purinergic signalling is involved in hormone secretion, penile erection, sperm motility and capacitation, and mucous production. Changes in purinoceptor expression occur in pathophysiological conditions, including pre-eclampsia, cancer and pain.

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Purinergic signalling in the reproductive system in health and disease

Burnstock

2013

Purinergic Signalling

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Cellular Distribution and Functions of P2 Receptor Subtypes in Different Systems

Burnstock

Knight

2004

International Review of Cytology

709

624

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This review is aimed at providing readers with a comprehensive reference article about the distribution and function of P2 receptors in all the organs, tissues, and cells in the body. Each section provides an account of the early history of purinergic signaling in the organ?cell up to 1994, then summarizes subsequent evidence for the presence of P2X and P2Y receptor subtype mRNA and proteins as well as functional data, all fully referenced. A section is included describing the plasticity of expression of P2 receptors during development and aging as well as in various pathophysiological conditions. Finally, there is some discussion of possible future developments in the purinergic signaling field.

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EFFECT OF CAFFEINE AND PENTOXIFYLLINE ON HUMAN SPERM MOTILITY AFTER ONE WEEK STORAGE AT 3^|^deg;C

Kanno

Kinoshita²,

Saito³

et al. 1995

Jpn. j. urol

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The effect of caffeine (C) and pentoxifylline (P) on the sperm motility was examined after a 3 degrees C storage in a TEST yolk buffer for one week. Thus stored 24 semen samples from infertile patients were incubated with or without C or P at 37 degrees C. The motility was analysed for up to 240 minutes. The poststorage addition of C (1 mM) and P (1 mM) significantly increased the serum motility rate (p < 0.01). The stimulant effect of C and P was rather transient lasting no more than 2 hours. The prestorage addition of C and P in a preservant TEST yolk buffer was less effective than the poststorage administration. According to the time-related profiles of the sperm motility, 24 cases were divided into three groups. In group A (11 cases), the sperm motility rate increased from 30 to 90 minutes even without C or P. This group was responder of C and P. In group B (8 cases), the motility rate increased only in response to C and P and, in group C (5 cases), no such responses were observed. The prestorage semen qualities in terms of the sperm concentration, the motility rate, the velocity, the linearity, and the amplitude of the lateral head displacement were compared in these three groups. There was a significant difference between these 3 groups (p < 0.05) on the parameters in terms of the sperm concentration, motility rate and velocity. It was suggested that these prestorage parameters predict the sperm activity in response to C and P after a one week 3 degrees C storage.

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Use of an ATP-supplemented medium for the conservation of human semen and the effect of caffeine on the motility of preserved sperm. Results in artificial insemination.

Cited by 3 publications

References 12 publications

Purinergic signalling in the reproductive system in health and disease

Purinergic signalling in the reproductive system in health and disease

Cellular Distribution and Functions of P2 Receptor Subtypes in Different Systems

EFFECT OF CAFFEINE AND PENTOXIFYLLINE ON HUMAN SPERM MOTILITY AFTER ONE WEEK STORAGE AT 3^|^deg;C

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