Use of an autoinflation device does not lead to a clinically meaningful change in hearing thresholds in children with otitis media with effusion

Cooper, Hannah E.; Grifa, Ilaria; Bryant, Catriona

doi:10.1111/coa.13879

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…An open randomized study demonstrated moderate improvement among children with OME aged 4–11 years after insufflation therapy [ 6 ]. On the other hand, recently published results on the insufflation method were ambiguous [ 7 ]. Although a few clinical trials provided evidence for the efficiency of AMSA in OME, they included small and highly selective groups, which excluded adults [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Resolution of Otitis Media with Effusion in Adults after a Three-Day Course of Treatment with a Manosonic Nebulizer—A Pilot Study

Zasadzińska-Stempniak

Karwat

Jarmołowicz-Aniołkowska

et al. 2023

Medicina

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Background and Objectives: Aerosol drug administration is the primary treatment modality of otitis media with effusion (OME). An automatic manosonic aerosol generator (AMSA) delivers, with an acoustic overpressure, a therapeutic dosage of a drug by inhalation of the aerosol. However, available studies confirming their efficacy, especially in adults, are limited. Therefore, this pilot single-arm trial aimed to analyze changes in adults with OME following AMSA treatment. Materials and Methods: A group of 36 patients (mean age 51.4 years) with OME underwent a three-day treatment with inhaled mucolytic and steroids administered by AMSA. Tympanometry (tympanogram type, volume, compliance, pressure, and gradient) was performed to measure middle ear effusion before and after the intervention. Results: Following the intervention, partial and complete OME remission was observed in, respectively, 29 (81%) and 14 (39%) patients. The tympanogram type of the affected ears differed between baseline and after intervention measurements (p < 0.001). Tympanometry-based normalization, improvement deterioration and no change were observed in, respectively, 34 (68%), 1 (2%) 2 (4%), and 13 (26%) affected ears. Following the intervention, we observed an increase in continuously assessed middle ear volume (∆median 0.19 mL, p = 0.002) and pressure (∆median 142 daPa, p < 0.001), as well as a higher proportion of patients achieving categorical normalization of compliance (16% vs. 54%, p < 0.001) and pressure (28 vs. 64%, p < 0.001). Conclusions: Treatment efficacy was not affected by age, sex, or season of recruitment (all p > 0.05). The results of this pilot study are encouraging, however, the use of AMSA management of OME in adults needs to be verified in future studies.

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Section: Introductionmentioning

confidence: 99%

Resolution of Otitis Media with Effusion in Adults after a Three-Day Course of Treatment with a Manosonic Nebulizer—A Pilot Study

Zasadzińska-Stempniak

Karwat

Jarmołowicz-Aniołkowska

et al. 2023

Medicina

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ISOM 2023 Research Panel 5: Interventions- Vaccines and prevention, medical and surgical treatment, and impact of COVID-19 pandemic

Pelton,

Hullegie,

Leach

et al. 2024

International Journal of Pediatric Otorhinolaryngology

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Natural history of otitis media with effusion-related hearing loss in children under 12 years: a systematic review

Paing,

Elliff-O’Shea,

Day

et al. 2024

Arch Dis Child

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ObjectiveTo assess natural history of otitis media with effusion (OME)-related hearing loss and OME causing hearing loss in children under 12 years.MethodsEmbase, MEDLINE, CINAHL, INAHTA database, CENTRAL, CDSR, Epistemonikos and PsycINFO were searched to identify observational single group studies, and comparative studies with untreated control arms published in English up to June 2022, reporting natural history of OME-related hearing loss and OME causing hearing loss. Risk of bias and overall quality of evidence were assessed using the JBI (Joanna Briggs Institute (JBI) checklist and GRADE (Grading of Recommendations Assessment, Development and Evaluation) methodology, respectively.ResultsThirteen studies with 24–639 children were included. Resolution of OME-related hearing loss was 50% by 3 months, 60% by 6 months and 61–77% by 12 months. Resolution of OME causing hearing loss (OME of <1 month, >3 months, >6 months or unknown duration before follow-up) was 23–55% by 3 months, 20–50% by 6 months, 31% by 9 months and 21–93% by 12 months, depending on population and how resolution was defined. Resolution of chronic OME (OME of >12 months duration before follow-up) was only 7% by 1 month, 12% by 6 months and 6% by 12 months. Resolution was only 42% by 57 months in children with primary ciliary dyskinesia.ConclusionsThere was greater resolution of OME-related hearing loss over longer follow-up periods. Resolution of OME causing hearing loss also showed a trend towards greater resolution over longer follow-up periods; however, this did not follow a linear pattern, potentially due to differences in populations and definitions of resolution across studies.

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Use of an autoinflation device does not lead to a clinically meaningful change in hearing thresholds in children with otitis media with effusion

Cited by 3 publications

References 17 publications

Resolution of Otitis Media with Effusion in Adults after a Three-Day Course of Treatment with a Manosonic Nebulizer—A Pilot Study

Resolution of Otitis Media with Effusion in Adults after a Three-Day Course of Treatment with a Manosonic Nebulizer—A Pilot Study

ISOM 2023 Research Panel 5: Interventions- Vaccines and prevention, medical and surgical treatment, and impact of COVID-19 pandemic

Natural history of otitis media with effusion-related hearing loss in children under 12 years: a systematic review

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