Use of an Octapeptide–Guanidiniocarbonylpyrrole Conjugate for the Formation of a Supramolecular β‐Helix that Self‐Assembles into pH‐Responsive Fibers

Abstract

Peptides that adopt b-helix structures are predominantly found in transmembrane protein domains or in the lipid bilayer of vesicles.Constructing a b-helix structure in pure water has been considered difficult without the addition of membrane mimics.Herein, we report such an example;peptide 1 self-assembles into as upramolecular b-helix in pure water based on charge interactions between the individual peptides. Peptide 1 further showed intriguing transitions from small particles to helical fibers in at ime-dependent process.T he fibers can be switched to vesicles by changing the pH value.