Use of an Osmotic Diuretic—THAM—in Treatment of Barbiturate Poisoning

Balagot, Reuben C.

doi:10.1001/jama.1961.03040490026006

Cited by 22 publications

(8 citation statements)

References 9 publications

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“…Except for local venospasm at the site of infusion, no side effects were observed and no assistance in ventilation was considered necessary. 3 THAM is excreted in the urine over a period of three days and it may accumulate in the body if large doses are given frequently. The amount that can be safely accumulated has not yet been determined.…”

mentioning

confidence: 99%

The clinical pharmacology of THAM [tris(hydroxymethyUami nomethane]

Nahas

1963

Clin Pharma and Therapeutics

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confidence: 99%

The clinical pharmacology of THAM [tris(hydroxymethyUami nomethane]

Nahas

1963

Clin Pharma and Therapeutics

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“…2,7 Reported arrhythmias in dogs included bradycardia, sinus tachycardia, first and second-degree atrioventricular block, ventricular tachycardia and ventricular fibrillation. 5,11 However, Camplesi et al (2010) studied electrocardiographic changes in dogs subjected to toad poisoning in an experimental setting and reported 46% of the poisoned dogs had arrhythmias. 100% of these dogs had ventricular premature complexes and 71% had ventricular tachycardia.…”

Section: Discussionmentioning

confidence: 99%

“…2 It has been estimated that the lethal oral dose of toad venom to be the entire contents of both parotid glands, the equivalent of 0.1 g of venom per dog. 5 Dogs are frequently presented to veterinarians for toad toxicity within the region of Australia where they are found. With early and appropriate treatment, the outcome has been reported as excellent; improvement of clinical signs occurs within the first 24 h, even for severely affected patients.…”

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confidence: 99%

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A retrospective study of cane toad (Rhinella marina) toxicity in 190 domestic cats in Southeastern Queensland: Clinical presentations, treatments, and outcomes

Leong¹,

Padula

Webster³

et al. 2023

Aust Veterinary J

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Objective To report the clinical presentations, treatments and outcomes of toad toxicity in domestic cats in Southeastern Queensland, Australia. Methods This report describes a retrospective study of 190 cases of cane toad (Rhinella marina) toxicity in cats in south‐eastern Queensland, Australia. All cases were presented for veterinary treatment between 2011 and 2020 at four specialist veterinary emergency centres in Southeast Queensland, Australia. Cane toad toxicity was diagnosed based on a history of exposure and clinical signs. Results Domestic short‐hair breeds accounted for 53.6% of the cases. Presentation was seasonal with the highest incidence over the warmer months of the year (November – March). Hypersalivation was described in 96.3% (183/190), tachypnoea in 34.2% (65/190) and altered behaviour in 18.4% (35/190) of cases. Seizures occurred in 1% of cases. Of the 190 cases, 6.3% (12/190) were hospitalised and 0.5% (1/190) were euthanised and overall 99.5% (189/190) survived hospital discharge. Clinical significance Cane toad toxicity is relatively common in cats in Southeast Queensland and following buccal lavage the prognosis for recovery was excellent.

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“…11 Other trials included attempts to increase the secretion of barbituric acid in cases of barbituric acid intoxication. 12 …”

Section: Introductionmentioning

confidence: 99%