Use of Anilines in the Petasis Reaction: DFT Mechanistic Study

Ulaş, Yeliz

doi:10.1134/s1070428022030228

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…The amount of p ‐TSA and reaction temperature were also evaluated, but no better results were obtained (entries 15–18). Additionally, we repeated the reaction according to the literature [9d] . Unfortunately, imine from salicylaldehyde ( 1 a ) and p ‐anisidine ( 3 a ) was obtained as a main product and provided 4 a in a very low yield (entry 19).…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Arylamines via a Tandem Petasis Borono‐Mannich/ Nucleophilic Substitution Reaction

Yang

et al. 2023

Asian J Org Chem

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An efficient and practical one‐pot reaction for the synthesis of diarylmethyl anilines from easy available materials of salicylaldehydes, arylboronic acids and aromatic amines has been successfully developed. All the reactions proceed smoothly under transition‐metal‐free conditions via a p‐TSA promoted tandem Petasis borono‐Mannich/ nucleophilic substitution reaction, providing highly functionalized amines with wide functional groups in good to excellent yields. A reasonable explanation for this transformation was suggested.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Arylamines via a Tandem Petasis Borono‐Mannich/ Nucleophilic Substitution Reaction

Yang

et al. 2023

Asian J Org Chem

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“…The PDB entry 3GTV was selected as the appropriate receptor for the docking process. Molecular docking is highly important for examining ligand–protein interactions [ 19 ]. Molecular docking procedure in this study was conducted using the AutoDock Vina program [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

A Holistic In Silico and In Vivo Approach to Exploring the Antidiabetic, Antioxidant, and Hepatoprotective Properties of Rose of Sharon

Ziyanok-Demirtas

2024

Life

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Diabetes mellitus (DM) is a significant global health burden that necessitates the exploration of effective and accessible therapeutic options. Phytotherapy has played a vital role in healthcare, with plant extracts being integral to traditional medicinal practices. The therapeutic potential of Hibiscus syriacus (Rose of Sharon), a plant with a rich ethnobotanical history, in the management of DM and its associated complications was investigated. In this study, the therapeutic potential of Hibiscus syriacus L. extract (HSE) against DM in streptozotocin (STZ)-induced diabetic rats was assessed, focusing on its effects on glucose regulation, antioxidative defense, and liver protection. The administration of the HSE extract substantially reduced hyperglycemia and increased insulin production, with concurrent improvements in body weight and hydration. The enhanced activity of antioxidant enzymes, such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), suggests reduced oxidative stress, which is further supported by molecular docking results with the 3GTV superoxide dismutase enzyme, showing a binding energy of −6.3 kcal/mol. A decrease in MDA levels also indicates a reduction in oxidative stress. Notably, HSE treatment led to decreased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels and improved lipid profiles, indicating its hepatoprotective and lipid-modifying benefits. These findings support the inclusion of HSE as an adjunctive therapy in DM management strategies. This study promotes the consideration of Hibiscus syriacus L. therapeutic properties in global health contexts.

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Synthesis of 2-((1H-indol-1-yl)(naphthalen-1-yl)methyl)phenol Compound and Investigation of NLO Properties by Quantum Chemical Calculations

Ulaş

2022

Caucasian Journal of Science

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Bu çalışmada, 2-((1H-indol-1-il)(naftalen-1-il)metil)fenol bileşiği ilk kez sentezlenmiş olup, yapısal analizi 1H-NMR, 13C-NMR, FT-IR gibi spektroskopik yöntemlerle deneysel ve teorik olarak incelenmiştir. Bileşiğe ait birçok özellik; spektral veriler, bağ uzunluğu, bağ açısı, dihedral açıları, molekül yüzeyi, FMO analizi ve doğrusal olmayan optik (NLO) özellikleri de teorik olarak araştırılmıştır. Hesaplamalar; HF ve DFT/B3LYP metotları ile 6-311++G(d,p) temel seti kullanılarak gerçekleştirilmiştir. Elde edilen veriler ışığında, alkilaminofenollerin, medikal uygulamalar haricinde optoelektronik alanda da kullanılabileceği ön görülmüştür

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Use of Anilines in the Petasis Reaction: DFT Mechanistic Study

Cited by 3 publications

References 32 publications

Synthesis of Arylamines via a Tandem Petasis Borono‐Mannich/ Nucleophilic Substitution Reaction

Synthesis of Arylamines via a Tandem Petasis Borono‐Mannich/ Nucleophilic Substitution Reaction

A Holistic In Silico and In Vivo Approach to Exploring the Antidiabetic, Antioxidant, and Hepatoprotective Properties of Rose of Sharon

Synthesis of 2-((1H-indol-1-yl)(naphthalen-1-yl)methyl)phenol Compound and Investigation of NLO Properties by Quantum Chemical Calculations

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