Use of antibiotics in traumatic mandibular fractures: a systematic review and meta-analysis

Dawoud, Basim; Kent, Samuel; Henry, Alastair; Wareing, Jonathan; Chaudry, Hafsa Tahir; Kyzas, Panayiotis; MTReC,

doi:10.1016/j.bjoms.2021.01.018

Cited by 19 publications

(18 citation statements)

References 35 publications

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“…The same result was empowered by Delaplain’s results [ 27 ], who stated that anatomical location of the fracture, if important for surgical planning and strategy, does not influence the rate of infection rate when a short course of AP is prescribed. Considering mandible fractures, Dawoud [ 28 ] confirmed these findings with the latest meta-analysis published on the topic. However, the authors stated a high risk of bias of the studies considered, with a clear weakening of the results and a capital need for stronger evidence.…”

Section: Discussionmentioning

confidence: 62%

See 1 more Smart Citation

Antibiotic Prophylaxis in Torso, Maxillofacial, and Skin Traumatic Lesions: A Systematic Review of Recent Evidence

Cicuttin

Sartelli

Scozzafava³

et al. 2022

Antibiotics

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Use of antibiotic prophylaxis (AP) in trauma patients is a common practice. However, considering the increasing rates of antibiotic resistance, AP use should be questioned and limited only to specific cases. We performed a systematic review of recent literature (from year 2000), aiming to summarize the state of the art on efficacy and appropriateness of AP in patients with traumatic injuries of torso, maxillofacial complex and skin (including burns). Twenty-six articles were selected. In thoracic trauma, AP could be useful in reducing infective complications in tube thoracostomy for penetrating trauma. In maxillo-facial trauma, AP could find a role in the peri-operative trauma setting in the case of a graft or prosthetic implant. In abdominal trauma, there is a lack of consensus on the definition of contamination, infection, antibiotic therapy, and prophylaxis. In burned patients, routine AP is not suggested. In the case of human bites to the extremities, AP could find an indication. Future studies should focus on the subcategories of patients at higher risk of infection, identifying those who would benefit from AP. Attention to antimicrobial stewardship and guidelines focused on AP in trauma are required, to reduce antibiotic abuse, and increase quality research.

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Section: Discussionmentioning

confidence: 62%

“…In 2021, Dawoud et al [ 28 ] published a systematic review and meta-analysis, including 7 RCTs and 9 retrospective studies. The authors stated that, when comparing patients who received AP with those who received none, there was no clear advantage of AP in reducing adverse effects.…”

Section: Resultsmentioning

confidence: 99%

Antibiotic Prophylaxis in Torso, Maxillofacial, and Skin Traumatic Lesions: A Systematic Review of Recent Evidence

Cicuttin

Sartelli

Scozzafava³

et al. 2022

Antibiotics

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show abstract

“…A recent systematic review and meta-analysis by Dawoud and colleagues sought to characterize the effect of perioperative antibiotic usage on the rate of surgical site infection requiring any treatment beyond the normal postoperative protocol, and secondary outcomes included any complication requiring further intervention. 10 Despite including 16 studiesincluding 7 RCTs -encompassing 3,285 patients, their analysis was unable to determine an optimal prophylactic antibiotic strategy. Instead, they found significant between-study variation in choice of antibiotic regimen (i.e.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Patients who received at least one dose of peri-operative antibiotics fared better than patients who received no antibiotic coverage across multiple studies 5,7,10 Patients undergoing ORIF should receive at least one dose of perioperative antibiotics…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Post-operative  Extended antibiotic coverage beyond the acute operative peri-operative period do not definitively provide additional patient benefit across multiple RCTs, though these studies have many limitations and confounding patient factors make the results difficult to interpret [10][11][12][13]15,16 Antibiotic therapy may be offered, especially to patients with multiple risk factors for post-operative infection Optional Table 1. Summary recommendations for antibiotic use in the treatment of mandibular fractures.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Evidence-Based Medicine for Mandible Fracture Repair: Current Controversies and Future Opportunities

Barrett

Author

2023

Facial Plast Surg

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Mandibular fractures are among the most common facial fractures resulting from trauma. The nature of the injury, involved facial structures, presence of associated injuries, the dental status of the patient, co-morbid conditions, and psycho-social context all must be considered by the surgeon when planning the optimal treatment for these patients. While consensus exists for many aspects of the management mandibular trauma, some elements of remain controversial. Three such topics – antibiotic therapy, treatment of subcondylar fractures, and management of the third molar – remain particularly controversial, with significant heterogeneity in practice patterns and without widely accepted evidence based guidelines to standardize care. The goals of this work are to 1) review the historical perspective underlying these controversies, 2) summarize recent evidence shaping the current debate, and 3) highlight opportunities for continued efforts to identify best practices.

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Should Systemic Antibiotics be Used Regularly for Mandible Fractures?

2023

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Use of antibiotics in traumatic mandibular fractures: a systematic review and meta-analysis

Cited by 19 publications

References 35 publications

Antibiotic Prophylaxis in Torso, Maxillofacial, and Skin Traumatic Lesions: A Systematic Review of Recent Evidence

Antibiotic Prophylaxis in Torso, Maxillofacial, and Skin Traumatic Lesions: A Systematic Review of Recent Evidence

Evidence-Based Medicine for Mandible Fracture Repair: Current Controversies and Future Opportunities

Should Systemic Antibiotics be Used Regularly for Mandible Fractures?

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