Use of antiepileptic mood stabilizers in dermatology

Gupta, Madhulika A.; Pur, Daiana R.; Vujcic, Branka; Gupta, Aditya K.

doi:10.1016/j.clindermatol.2018.08.005

Cited by 18 publications

(10 citation statements)

References 67 publications

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“…In the literature immunosuppressants and gabapentin have been described as effective systemic therapies for pruritus (13,14). This was also found in the EADV Task Force Pruritus survey, in which 27% and 17% of physicians reported immunosuppressants and gabapentin as the most effective therapies (8).…”

Section: Main Findings and Interpretationmentioning

confidence: 72%

Treatment and Burden of Disease in a Cohort of Patients with Prurigo Nodularis: A Survey-based Study

Todberg

Zachariae²,

Skov³

2020

Acta Derm Venerol

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Prurigo nodularis is a rare skin disease characterized by intense pruritus, leading to lack of sleep and reduced quality of life. For dermatologists worldwide, treatment of prurigo nodularis remains a challenge, as there are no approved treatments for the disease and patients are often insufficiently treated with the existing therapies. This patientbased survey examined treatment tendencies and treatment effectiveness, comorbidities, pruritus and quality of life in a cohort of patients with prurigo nodularis. Overall, topical corticosteroids and ultraviolet B are the most commonly used treatments; however, topical corticosteroids under occlusion, zinc-dressing treatment and steroid injection were reported as the most effective treatments. Prurigo nodularis is a pruritic dermatosis with poor treatment options. To describe treatment patterns, comorbidities, pruritus, and quality of life a survey was administered to 92 patients with prurigo nodularis. A total of 52 patients completed the survey. The most frequently used treatments were topical corticosteroids, which were prescribed to 49/52 patients, with positive effect in 13/49. A total of 46/52 patients were treated with ultraviolet B, and 9/46 reported a positive effect. A positive effect was reported for topical corticosteroids under occlusion in 21/40, for zinc dressing treatment in 17/37, for steroid injection in 9/14, for methotrexate in 5/16, and for thalidomide in 4/12 of treated patients. Thirty-six patients reported a Pittsburgh Sleep Quality Index >5, indicating poor sleep. Patients with prurigo nodularis are severely bothered by pruritus negatively affecting quality of life. Various treatments are prescribed; most frequently topical corticosteroids and ultraviolet B. Surprisingly, patients reported topical corticosteroids under occlusion, zincdressing treatment and steroid injection as the most effective.

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Section: Main Findings and Interpretationmentioning

confidence: 72%

Treatment and Burden of Disease in a Cohort of Patients with Prurigo Nodularis: A Survey-based Study

Todberg

Zachariae²,

Skov³

2020

Acta Derm Venerol

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“…ere are few reports of valproate being successfully used to manage cases of inflammatory verrucous epidermal nevi. [28] e preferred target dosage of sodium valproate is…”

Section: Sodium Valproatementioning

confidence: 99%

Selection of psychotropics in dermatologic practice

Menon

Selvakumar

Faheem

2021

CSDM

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There is an increased prevalence of psychiatric symptoms in dermatologic disorders. However, these are often underrecognized and undertreated contributing to suboptimal adherence and therapeutic outcomes. A working knowledge of psychotropic medications and their use in dermatology is essential for comprehensive management of psychodermatological conditions. The present review provides a framework for use of psychotropic agents in dermatological settings and is intended to serve as a ready reckoner for the dermatologist. We initially review the general considerations involved in prescribing psychotropic agents in skin conditions. Next, we discuss individual classes of psychotropic agents such as anti-depressants, mood stabilizers, antipsychotics, and anxiolytics focusing on preferred agents while prescribing. Finally, we discuss the common adverse cutaneous reactions reported with psychotropic agents.

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“…PD indications of anti-epileptics include cutaneous neuropathic pain, itch, and complex cutaneous sensory syndromes, where CNS sensitization plays a role, repetitive excoriation behaviors such asprurigo nodularis, lichen simplex chronicus, skin picking, and TTM, psychophysiologic conditions such as urticaria, flushing, and social anxiety. [ 65 ]…”

Section: Antipsychoticsmentioning

confidence: 99%