Use of antipruritic and rehydrating foams on localized lesions of atopic dermatitis in dogs: a small‐scale pilot and comparative double‐blinded study

Bensignor, Emmanuel; Fabriès, Lionel J.

doi:10.1111/vde.12675

Cited by 9 publications

(7 citation statements)

References 10 publications

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“…Similar improvement rates were obtained by commonly used drugs (e.g., ciclosporin, prednisolone, oclacitinib), although they were associated with greater side effects [52][53][54][55][56][57][58]. The mean reduction in pruritus observed in this study after fourteen days (42%) was higher than those following the application of two commercially available dermatological mousses tested as monotherapy on eight atopic dogs in a previous study (26% and 33% for Foam A and Foam B, respectively) [59]; however, unlike our study, concomitant medications, including shampoos were not allowed in such a protocol.…”

Section: Discussionsupporting

confidence: 78%

Effects of a Protocol Combining a Non-Irritating Shampoo and an Adelmidrol-Based Adsorbent Mousse on Seborrhoea and Other Signs and Symptoms Secondary to Canine Atopic Dermatitis: A Multicenter, Open-Label Uncontrolled Clinical Trial

Noli,

Morelli,

della Valle

et al. 2024

Veterinary Sciences

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The present study aimed at evaluating the effect of a gentle shampoo and a mousse containing Adelmidrol, tapioca starch and a non-prescription antimicrobial complex on seborrhoea and other clinical signs secondary to canine atopic dermatitis (cAD). Forty-six dogs with cAD-associated seborrhoea and/or pruritus > 4 cm on the pruritus visual analogue scale (P-VAS) and/or bacterial/Malassezia overgrowth were enrolled. The mousse was applied twice daily, and dogs were evaluated at days (D)0, 7, 14 and optionally 28, by means of a skin seborrheic index (SSI), P-VAS, cAD lesion index (CADLI), and a semiquantitative cytological score. The mean SSI value improved during the first two weeks (4.1 ± 0.37 to 1.9 ± 0.30; p < 0.0001). The mean P-VAS score (cm) decreased from 6.6 ± 0.19 at D0 to 3.8 ± 0.31 at D14 (p < 0.0001). The mean CADLI score dropped from 13.7 ± 1.24 to 8.5 ± 1.14 at D14 (p < 0.001). The cytological score for bacteria and Malassezia decreased from 3.2 ± 0.10 and 3.2 ± 0.11, respectively, to 1.2 ± 0.19 and 1.2 ± 0.24 (p < 0.0001). All the investigated signs further improved at D28. Altogether, these observations suggest that the tested protocol might be useful in managing cAD-associated signs.

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Section: Discussionsupporting

confidence: 78%

Effects of a Protocol Combining a Non-Irritating Shampoo and an Adelmidrol-Based Adsorbent Mousse on Seborrhoea and Other Signs and Symptoms Secondary to Canine Atopic Dermatitis: A Multicenter, Open-Label Uncontrolled Clinical Trial

Noli,

Morelli,

della Valle

et al. 2024

Veterinary Sciences

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“…The application of a mousse is simple through massage, it does not require prior wetting of the skin, nor rinsing or drying afterwards, thus allowing longer direct skin contact and prolonged action [ 30 ]. In recent years, mousse formulations, containing either phytosphingosine and pseudofilaggrin [ 31 ], or plant extracts [ 32 ] have been used in the management of canine atopic dermatitis, in spontaneous cases, improving skin lesions and pruritus. In another study, the authors showed that a mousse containing phytosphingosine and pseudofilaggrin could decrease the skin pH and inflammation in an experimental model of impaired skin barrier [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Performance and Tolerance of a Protocol for Idiopathic Chronic Greasy Seborrhea in 18 Dogs Using a Shampoo and Mousse Containing Plant Extracts

Kondratjeva

Brun

Amalric³

et al. 2023

Veterinary Sciences

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The study aimed to evaluate the tolerance, performance and effect on hair lipids and skin hydration of a protocol combining applications of one shampoo and subsequent mousses containing plant extracts (Ophytrium and Seboliance) in dogs with an undiagnosed chronic greasy keratinisation disorder. Six dogs were washed with plain water on day (D)0. Twelve dogs were shampooed on D0 and received eight mousse applications at 48–72 h intervals from D2 to D18. Clinical score (CS), Natural Moisturizing Factors (NMF) and hair lipids (HL) were evaluated on D0, D0 + 4 h, D7, D14 and D24. At baseline, no significant differences were observed in CS, NMF and HL between groups. In the control group, CS and HL remained stable throughout the study while a slight decrease in NMF was observed at D0 + 4 h. CS was significantly reduced in the test group between D0 and D7 (−53%) which reached 91% at D24 (p < 0.05), with no side effects. NMF levels decreased in the test group at D0 + 4 h (−73%, p < 0.0001) and returned to baseline from D14. In conclusion, one shampoo and subsequent mousse applications rapidly and safely improved coat quality in dogs with an undiagnosed keratinisation disorder without affecting NMF and HL contents over the study period.

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“…The efficacy of topical formulations containing essential fatty acids, with or without ceramides and/or cholesterol plus various additional ingredients, was compared to each other in one RCT 68 and to placebo in four RCTs. 11,[69][70][71] Due to a lack of positive controls, a MS could not be assigned to these formulations.…”

Section: Topical Essential Fatty Acid And/or Ceramide And/or Cholestementioning

confidence: 99%

A proposed medication score for long‐term trials of treatment of canine atopic dermatitis sensu lato

Saridomichelakis

Favrot

Jackson³

et al. 2021

Veterinary Record

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Background: The use of concurrent medications is necessary in trials of treatment of canine atopic dermatitis. Our aim was to use the best available evidence to construct and then to validate a medication score (MS) formula that will estimate the impact of concurrent medications on trial outcomes. Methods: Trials of 15 interventions were scrutinized to find those that were consistent in terms of specific medication, administration route and dosage regimen. A MS was constructed in five steps, starting from assigning a score of 1 for each day on oral prednisone, prednisolone or methylprednisolone at 0.5–1.0 mg/kg. The MS score was validated using the clinical records of 35 dogs with atopic dermatitis that had been treated for a period of 12 ± 2 weeks with six of these medications and compared with a previously published non‐validated MS. Results: A MS could be assigned to eight treatments, six of which had been administered to the 35 dogs. A positive correlation was seen with the previously published MS and a negative correlation with changes in lesional and pruritus scores. Conclusion: This MS may be a useful tool in new studies evaluating the efficacy of treatments in canine atopic dermatitis

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Use of antipruritic and rehydrating foams on localized lesions of atopic dermatitis in dogs: a small‐scale pilot and comparative double‐blinded study

Abstract: The use of a foam may be useful in cAD to improve both skin lesions and pruritus. Both foams evaluated in this study were equally effective. This method of product delivery is easy to use for owners which is important to improve compliance in practice.

Cited by 9 publications

References 10 publications

Effects of a Protocol Combining a Non-Irritating Shampoo and an Adelmidrol-Based Adsorbent Mousse on Seborrhoea and Other Signs and Symptoms Secondary to Canine Atopic Dermatitis: A Multicenter, Open-Label Uncontrolled Clinical Trial

Effects of a Protocol Combining a Non-Irritating Shampoo and an Adelmidrol-Based Adsorbent Mousse on Seborrhoea and Other Signs and Symptoms Secondary to Canine Atopic Dermatitis: A Multicenter, Open-Label Uncontrolled Clinical Trial

Performance and Tolerance of a Protocol for Idiopathic Chronic Greasy Seborrhea in 18 Dogs Using a Shampoo and Mousse Containing Plant Extracts

A proposed medication score for long‐term trials of treatment of canine atopic dermatitis sensu lato

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