Use of Antisense Oligonucleotides as Therapy for Huntington's Disease
Ariel Solis-Chiriboga,
Alberto Bustillos
Abstract:Introduction: Huntington's disease is a neurodegenerative disorder characterized by the progressive degeneration of nerve cells in the brain, and whose current treatment focuses on the control of symptoms, which is why in recent years several therapies have been evaluated, including Antisense oligonucleotides a promising strategy, thanks to their ability to modulate the expression of the mutated huntingtin protein.Methods:A bibliographic search was carried out using the PRISMA methodology in databases such as … Show more
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