Use of aromatase inhibitors in practice of gynecology

Usluoğulları, Betül; Duvan, Candan Zehra; Usluoğulları, Celil Alper

doi:10.1186/s13048-015-0131-9

Cited by 34 publications

(18 citation statements)

References 73 publications

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“…This might be attributable to the complete clearance of LTZ after approximately 10–12 days from its last dose (Usluogullari et al . ). However, it may take a longer time to downregulate the inflammatory cytokines produced in the tubo‐ovarian milieu.…”

Section: Discussionmentioning

confidence: 97%

“…The inhibition of aromatization by LTZ results in a local increase in androgens that potentiate the follicular sensitivity to FSH (Usluogullari et al . ). The latter receptors are upregulated in OSE overlying large follicles (Saddick ), suggesting that gonadotropins may have a differential local growth‐stimulating effect (Ng & Barker ).…”

Section: Discussionmentioning

confidence: 97%

“…This aromatization is inhibited by aromatase inhibitors such as letrozole (LTZ) which is as effective as the first line fertility drug, clomiphene citrate (CC) (Usluogullari et al . ).…”

Section: Introductionmentioning

confidence: 97%

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Reversal of tubo‐ovarian atypical epithelial patterns after cessation of ovarian stimulation by letrozole

Abdel-Hamid

Mesbah

Soliman

2016

Int J Experimental Path

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Letrozole (LTZ), one of the ovulation induction medications, is increasingly prescribed in various gynaecological conditions. Previous studies have demonstrated its potential hazardous effect on the ovarian surface epithelium (OSE) as well as on tubal epithelial cells (TEC). However, it is not clear whether this effect could be reversed by LTZ cessation. Therefore, the objective of our study was to investigate the effect of stoppage of LTZ on these cells after 12 cycles of ovarian stimulation. A total of 54 Sprague Dawley rats were used in this study, divided equally into control, LTZ12 and CES12 groups (received saline, 12 cycles of LTZ and 12 cycles of cessation post-LTZ12 respectively). Samples from the ovaries as well as fallopian tubes (FTs) were studied histologically for the changes associated with LTZ12 and CES12 respectively. There was evident increase in the proliferative activity and Ki67 immunoexpression in the OSE of LTZ12. The OSE was hyperchromatic, and abnormally frequent deep invaginations, micropapillae and cortical cysts. Their TEC showed frequent multilayering, papillary projections and loss of cilia. Almost all these changes disappeared 12 cycles after LTZ cessation. While the tubal IL-1β, IL-6, TNF-α and serum MCP-1 levels significantly increased in the LTZ12 group compared with the control group, their levels decreased in the CES12 group compared with those of the control. Therefore, the abnormal tubo-ovarian epithelial patterns may completely regress after cessation of LTZ stimulation for a reasonable duration. This is a potentially good omen and a positive indicator of the relatively safe use of LTZ after its intake has been stopped.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

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Reversal of tubo‐ovarian atypical epithelial patterns after cessation of ovarian stimulation by letrozole

Abdel-Hamid

Mesbah

Soliman

2016

Int J Experimental Path

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“…Aromatase is found in several tissues including the ovaries, liver, breasts, brain, and adipose tissue [58][59][60].…”

Section: Vitamin D and Steroidogenesismentioning

confidence: 99%

Vitamin D and Human Reproduction

Tehrani¹,

Behboudi‐Gandevani²

2017

A Critical Evaluation of Vitamin D - Basic Overview

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Vitamin D is one of the steroid hormones. The precursor of vitamin D, 7-dehydrocholesterol, which is an intermediary for cholesterol pathway, is available in the skin. Ultraviolet B (UVB) radiation makes the transformation of 7-dehydrocholesterol to provitamin D3, which automatically isomerizes to cholecalciferol (vitamin D3). Vitamin D3 is secreted into blood circulation and carried by the vitamin D-binding protein (VDBP). Around 80-90% of vitamin D is from sunlight-derived production in the skin. A little amount of vitamin D is also extracted from foods and/or additional supplementation. Vitamin D has been well known for its function in maintaining calcium and phosphorus homeostasis and promoting bone mineralization. Accumulating evidence from animal and human studies suggests that vitamin D also modulates reproductive processes in women and men and is involved in many functions of the reproductive system. Vitamin D receptor (VDR) and vitamin D-metabolizing enzymes are found in reproductive tissues of women and men. This chapter presents an up-to-date review for describing the function of vitamin D in female reproduction throughout reproductive ages from menarche to menopause, during pregnancy and lactation, and some disorders affecting women and also the role of vitamin D applied to male fertility.

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“…Fratura de fragilidade ≤ 50 59 Terapia de privação de androgénios [60][61][62] Imobilização prolongada e paralisia [63][64] Glucocorticoides 65 Historial de quedas [5][6]8,11,18 Anticonvulsantes 66 Anorexia nervosa [67][68] Análogos da hormona libertadora de gonadotropinas (GnRH) 69-71 Deficiência de cálcio e de vitamina D 5,8,[72][73] Inibidores de aromatase [74][75][76][77][78] Absorção intestinal 8,79 Terapia antirretroviral 73,80 Artrite reumatoide 81 Hiperparatireoidismo [82][83] QUADRO III. Condições/doenças e tratamentos com impacto na DMO, conforme estabelecido em revisões sistemáticas da literatura e/ou em meta-análises documentos inibidores seletivos de recaptação de serotonina; Tamoxifen®; tiazolidinedionas hiazolidinedionas T (como Actos®); hormonas da tiroide (em excesso).…”

Section: Doentes Com As Seguintes Condições/doençasunclassified