Use of artificial neural networks to determine cognitive impairment and therapeutic effectiveness in Alzheimer's transgenic mice

Leighty, Ralph E.; Runfeldt, Melissa; Berndt, Donald J.; Schleif, William; Cracchiolo, Jennifer R.; Potter, Huntington; Arendash, Gary W.

doi:10.1016/j.jneumeth.2007.08.008

Cited by 9 publications

(6 citation statements)

References 44 publications

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“…For Study 2, direct entry DFAs were also performed, using 19 behavioral measures collected from the entire behavioral battery. A complete description of DFA multi-metric statistical analyses relevant to AD transgenic mouse studies can be found in Leighty et al [25,28]. …”

Section: Discussionmentioning

confidence: 99%

“…In this context, we have previously utilized discriminant function analysis (DFA) in reporting that caffeine treatment from young adulthood through older age "protects" APPsw mice from overall cognitive impairment across multiple cognitive domains [13,28]. To elucidate whether caffeine treatment in aged Tg mice provides "overall" cognitive ben- efit spanning multiple measures/domains (e.g., working/spatial memory, identification/recognition, general mnemonic function), we collectively evaluated all seven of the cognitive measures attained "during treatment" in the present study, utilizing direct entry DFA.…”

Section: Aged Tg Mice Show "Overall" Cognitive Benefit With Caffeine mentioning

confidence: 99%

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Caffeine Reverses Cognitive Impairment and Decreases Brain Amyloid-β Levels in Aged Alzheimer's Disease Mice

Arendash

Mori

Cao

et al. 2009

JAD

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287

223

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We have recently shown that Alzheimer's disease (AD) transgenic mice given a moderate level of caffeine intake (the human equivalent of 5 cups of coffee per day) are protected from development of otherwise certain cognitive impairment and have decreased hippocampal amyloid-beta (Abeta) levels due to suppression of both beta-secretase (BACE1) and presenilin 1 (PS1)/gamma-secretase expression. To determine if caffeine intake can have beneficial effects in "aged" APPsw mice already demonstrating cognitive impairment, we administered caffeine in the drinking water of 18-19 month old APPsw mice that were impaired in working memory. At 4-5 weeks into caffeine treatment, those impaired transgenic mice given caffeine (Tg/Caff) exhibited vastly superior working memory compared to the continuing impairment of control transgenic mice. In addition, Tg/Caff mice had substantially reduced Abeta deposition in hippocampus (decrease 40%) and entorhinal cortex (decrease 46%), as well as correlated decreases in brain soluble Abeta levels. Mechanistically, evidence is provided that caffeine suppression of BACE1 involves the cRaf-1/NFkappaB pathway. We also determined that caffeine concentrations within human physiological range effectively reduce active and total glycogen synthase kinase 3 levels in SweAPP N2a cells. Even with pre-existing and substantial Abeta burden, aged APPsw mice exhibited memory restoration and reversal of AD pathology, suggesting a treatment potential of caffeine in cases of established AD.

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Section: Discussionmentioning

confidence: 99%

Section: Aged Tg Mice Show "Overall" Cognitive Benefit With Caffeine mentioning

confidence: 99%

Caffeine Reverses Cognitive Impairment and Decreases Brain Amyloid-β Levels in Aged Alzheimer's Disease Mice

Arendash

Mori

Cao

et al. 2009

JAD

Self Cite

287

223

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“…As redes neurais artificiais (RNAs) têm sido usadas com sucesso como técnicas de inteligência artificial aplicada no auxílio ao diagnóstico clínico (Sun et al, 2011) e em classificação de padrões (Grassi et al, 2002;Buscema et al, 2007;Leighty et al, 2008). Devido a sua capacidade de aprendizado e de generalização, as RNA são capazes de aproximar funções complexas e não lineares.…”

Section: Introductionunclassified

Rede Neural Artificial Aplicada em um Sistema de Auxílio ao Rastreio de Depressão e de Qualidade de Vida de Idosos

Dainez¹,

Dainez²

2015

L&NLM

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Resumo -As redes neurais artificiais (RNA) têm sido usadas com sucesso como técnicas de inteligência artificial aplicada no auxílio ao diagnóstico clínico e em classificação de padrões. O presente trabalho desenvolve uma aplicação de RNA com objetivo de auxiliar a triagem e o diagnóstico de depressão em idosos de acordo com os fatores bio-psicossociais. Os dados para o treinamento da rede foram obtidos a partir dos instrumentos clínicos WHOQOL-bref e GDS 15, aplicados a um grupo de 12 idosos. Após o processo de treinamento a rede foi capaz de estimar a saída com um erro máximo de 4,6%, este resultado demonstra a viabilidade desta aplicação. Portanto, esta ferramenta pode ser empregada para determinar o estado de humor depressivo, reduzindo assim, a bateria de testes utilizados para esse fim, não desgastando o idoso e o familiar com excessivas questões, bem como agiliza o processo de triagem, diagnóstico e pesquisa clínica. Palavras-chave -Rede neural artificial, diagnóstico de depressão.Abstract -Artificial neural networks (ANN) have been used successfully as artificial intelligence techniques applied in aid clinical diagnosis and pattern classification. This paper develops an application of ANN in order to assist the screening and diagnosis of depression in the elderly according to the bio-psychosocial factors. Data for network training were obtained from clinical instruments WHOQOL-bref and GDS 15, applied to a group of 12 seniors. After the training process, the network was able to estimate the output with a maximum error of 4.6%, this result demonstrates the feasibility of this application. Therefore, this tool can be used to determine the state of depressed mood, thus reducing the battery of tests used for this purpose, not wearing the old and familiar issues with excessive questions, and streamlines the process of screening, diagnosis and clinical research.

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“…Behavioural responses involve complex morphological and physiological alterations in animals. These behavioural alterations in animals are often recorded for many purposes relevant to biomedical and biological research (Spink et al 2001;Leighty et al 2008). The tools used for recording behavioural alterations differ from a direct observation and/or manual recording to a completely automated locomotion recording system.…”

Section: Automated Behavioural Recordings (Video Digitisation)mentioning

confidence: 99%

“…Animals alter their behaviour during hot conditions, which is linked to complex physiological changes (Spink et al 2001;Leighty et al 2008). The tools used for recording behaviour vary from direct observation and/or manual recording to a completely automated locomotion recording system, using infrared or pressure sensors or various image processing methods (Spruijt et al 2006;Chen et al 2008;Junior et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Behavioural and physiological responses of beef cattle to hot environmental conditions

Idris¹

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Beef cattle are susceptible to hot environmental conditions, especially when provided with high levels of nutrition that lead to a significant heat increment in their bodies and high metabolic rate. The beef farming industry in hot regions experiences cattle deaths due to heat stress, resulting in significant economic loss, as well as poor health, welfare and production losses in many cattle throughout the industry. This thesis aims Contributions by others to the thesis

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Use of artificial neural networks to determine cognitive impairment and therapeutic effectiveness in Alzheimer's transgenic mice

Cited by 9 publications

References 44 publications

Caffeine Reverses Cognitive Impairment and Decreases Brain Amyloid-β Levels in Aged Alzheimer's Disease Mice

Caffeine Reverses Cognitive Impairment and Decreases Brain Amyloid-β Levels in Aged Alzheimer's Disease Mice

Rede Neural Artificial Aplicada em um Sistema de Auxílio ao Rastreio de Depressão e de Qualidade de Vida de Idosos

Behavioural and physiological responses of beef cattle to hot environmental conditions

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