Use of atomoxetine and suicidal ideation in children and adolescents: Results of an observational cohort study within general practice in England

Abstract

This study found no evidence of an increased risk of suicidal ideation during treatment with atomoxetine, compared to the period prior to starting treatment. Amongst age specific subgroups, this risk may change. Nonetheless, individual case assessment suggested a causal relationship in some patients, hence physicians need to be aware of the possibility of developing this event, and furthermore consider how best to detect it in this paediatric population. This study demonstrates the importance of combining quantitative statistical analyses with a qualitative case series assessment.

Overdiagnosis of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents

“…Activity (2) Lower levels of physical activity in treated vs untreated periods (1) 300 and youths (1) 301 Height (12) and weight (5) Growth delay (2) 302,303 and decreased growth (6) 297,[304][305][306][307][308] or weight (3) 304,305,308 No change observed and substantial heterogeneity (5) 267,301,303,309,310 Psychological (20) Other (2) Increased risk of psychosis (1) 311 and tics (1) 312 Substance abuse (12) No association of treatment with later substance abuse (4), [313][314][315][316] reduced risk (5), [317][318][319][320][321] and increased risk of stimulant abuse (1) 322 Prescription stimulant misuse or diversion in youths with or without ADHD (2) 323,324 Suicidal behavior (6) No association of treatment with risk of suicidal behavior (2), 325,326 reduced risk (3), [327][328][329] and increased risk (1) 330 Social and emotional (11) Emotional (3) Increased risk of irritability with amphetamine treatment (1) 331 Mixed outcomes for various emotional behaviors with stimulant treatment (1) 332 Decrease in happiness after increased medication treatment (1) 256…”

Attention‐deficit/hyperactivity disorder medication and risk of suicide attempt: A meta‐analysis of observational studies

“…The publication years ranged from 2014‐2020. Of the included studies, four 13,15,16,18 were cohort studies and one 14 was self‐controlled case series (SCCS) study. The remaining two 12,17 used cohort and within‐individual (one 17 was SCCS study) study design; thus, estimates provided by population level and within‐individual level analyzes were included in the meta‐analysis based on study design.…”

“…After analysis of randomized controlled trials, a black box warning was issued on atomoxetine mentioning the risk of suicidal ideation 7 . The effects of ADHD medication on suicide attempt have been investigated in an increasing number of epidemiological studies, 12‐18 but the results have been inconsistent. In some studies, 12,14 a lower risk of suicide attempt in patients taking ADHD medication was identified, but not in others 13,15 .…”

“…The effects of ADHD medication on suicide attempt have been investigated in an increasing number of epidemiological studies, 12‐18 but the results have been inconsistent. In some studies, 12,14 a lower risk of suicide attempt in patients taking ADHD medication was identified, but not in others 13,15 . Due to the limited number of suicide cases that occur during clinical trials, determining whether ADHD medications are associated with suicide attempt is important.…”

Biomedical Resource Oncology and Data Mining to Enable Resource Discovery in Medical, Medicinal, Clinical, Pharmaceutical, Chemical and Translational Research and Their Applications in Cancer Research

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Editorial 5-aminosalicylates, antacids, antidiarrheals, digestive enzymes, functional bowel disorder agents, anticholinergics/antispasmodics, chloride channel activators, guanylate cyclase-C agonists, peripheral opioid receptor antagonists, peripheral opioid receptor mixed agonists/ antagonists, serotoninergic neuroenteric modulators, gallstone solubilizing agents, GI stimulants, H. pylori eradication agents, H2 antagonists, laxatives, miscellaneous GI agents and proton pump inhibitors are important types of gastrointestinal agents because of their good processibility, environmental stability and oxidation or protonation-adjustable electrooptical properties as well as its potential for variety of applications electrospinning has attracted a lot of interest as a technique that is very simple and inexpensive to manufacture sub-micron fibres and Nano fibres as biomedical resource oncology and data mining to enable resource discovery in medical, medicinal, clinical, pharmaceutical, chemical and translational research and their applications in cancer research [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. It provides a potential way to fabricate infinite, continuous sub-micron fibres and Nano fibres.

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