Use of autologous fat grafting for breast reconstruction: A systematic review with meta-analysis of oncological outcomes

Agha, Riaz; Fowler, Alexander J.; Herlin, Christian; Goodacre, Tim; Orgill, Dennis P.

doi:10.1016/j.bjps.2014.10.038

Cited by 122 publications

(79 citation statements)

References 55 publications

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“…4,7,12 The main outcomes of interest were safety, effectiveness, and efficiency of AFG, and studies that reported data on these outcomes were included. Table 1 describes the components of each of the outcomes of interest.…”

Section: Methodsmentioning

confidence: 99%

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The Safety, Effectiveness, and Efficiency of Autologous Fat Grafting in Breast Surgery

Spear

Coles²,

Leung³

et al. 2016

Plastic and Reconstructive Surgery - Global Open

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Background:For years, the safety and effectiveness of autologous fat grafting (AFG) for breast reconstruction have been in question, with particular concern over fat necrosis, calcifications, cyst formation, and interfering with the detection of breast cancer. However, increasing evidence suggests that the complication rates and clinical results are generally acceptable to both clinicians and patients. The emerging challenge is the numerous AFG techniques and systems, where there are limited knowledge and data. The objective of this study was to conduct a literature review that focuses on the safety, effectiveness, and efficiency of various AFG techniques as applied to the breast.Methods:A PubMed search using terms related to AFG was performed over a 5-year period (April 1, 2010–April 30, 2015). Original articles focused on AFG to the breast, with outcomes on safety, effectiveness, and efficiency, were included.Results:Five hundred ninety-eight articles were identified with 36 articles included (n = 4306 patients). Satisfaction rates were high although the prevalence of complications was low—similar to previous findings. Seven studies reported average operating room time with an overall mean of 125 minutes (range: 40–210). The mean volume of fat harvested was 558 mL (range: 120–1299), and fat injected was 145 mL (range: 20–607). A positive association between injection volume and operating time was observed.Conclusions:This review validates previous findings on the safety and effectiveness of AFG to the breast and highlights its efficiency. The efficiency data available, although limited, suggest that there is an opportunity to achieve time and cost savings while not sacrificing safety and effectiveness.

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Section: Methodsmentioning

confidence: 99%

“…Given the dramatic increase in publications in the previous 5 years, the search focused on studies published during this time period (April 1, 2010–April 30, 2015). 4 …”

Section: Methodsmentioning

confidence: 99%

The Safety, Effectiveness, and Efficiency of Autologous Fat Grafting in Breast Surgery

Spear

Coles²,

Leung³

et al. 2016

Plastic and Reconstructive Surgery - Global Open

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show abstract

“…The rate of fat resorption remained stable after the ninth month, and even seemed to be lower (44.02%) after 3 years. In a review of 24 studies, Agha et al (43) reported 207 complications, occurring in 7.3% of 2832 treated breasts.…”

Section: Discussionmentioning

confidence: 99%

Autologous fat transplantation for secondary breast reconstruction: our experience

Simonacci¹

2017

GHIR

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“…Despite these concerns, in 2012, the ASPS Fat Graft Task Force did not find ''any reports suggesting an increased risk of malignancy associated with fat grafting'' and so far, clinical reviews have not revealed any increased cancerous relapse when using AFG to the breast [18,22,23].…”

Section: Introductionmentioning

confidence: 94%

Autologous Fat Grafting in the Breast: Critical Points and Technique Improvements

et al. 2015

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Use of autologous fat grafting for breast reconstruction: A systematic review with meta-analysis of oncological outcomes

Cited by 122 publications

References 55 publications

The Safety, Effectiveness, and Efficiency of Autologous Fat Grafting in Breast Surgery

The Safety, Effectiveness, and Efficiency of Autologous Fat Grafting in Breast Surgery

Autologous fat transplantation for secondary breast reconstruction: our experience

Autologous Fat Grafting in the Breast: Critical Points and Technique Improvements

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