Use of Biologic Agents in Extremity Reconstruction

Abstract

Skin and soft tissue defects of the lower extremity present a unique challenge for the reconstructive surgeon. Successful repair of the lower extremity relies not only on strong anatomical knowledge and surgical expertise, but also on careful consideration of the numerous preoperative factors and indications that may alter the patient's response to operative management. While many of these injuries result from burns, avulsive trauma, diabetes, or vascular insufficiencies, a significant portion can be associated with resection of neoplastic pathologies. This review outlines the uses, indications, and considerations for biologic wound agents in reconstructing skin and soft tissue defects of the lower extremity following Mohs micrographic surgery.

NovoSorb® Biodegradable Temporizing Matrix: a novel approach for treatment of extremity avulsion injuries in children

“…Decollements of extremities are rare in pediatric population, but often result in deep soft tissue defects requiring specialized plastic surgical treatment to obtain optimal functional and aesthetic results [1]. Established reconstructive surgical options for covering soft tissue defects in children include replantation, flaps, split-thickness skin grafts (STSG), tissue expansion and use of dermal skin substitutes (DSS) [2,3]. Petrie et al summarized eleven commercially available acellular skin matrices of human, bovine or porcine origin in a review [4].…”