Use of Biological Dosimetry for Monitoring Medical Workers Occupationally Exposed to Ionizing Radiation

Piotrowski, Igor; Dawid, Aleksandra; Kulcenty, Katarzyna; Suchorska, Wiktoria Maria

doi:10.3390/radiation1020009

Cited by 9 publications

(5 citation statements)

References 66 publications

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“…Dicentric chromosomes without accompanying fragments and pericentric inversions were also detected, both representing long-lived chromosome aberrations from past exposure ( 21 , 22 ). Numerous studies support our findings of increased rate of chromosome aberrations and high interindividual variability ( 23 , 24 , 25 ), which is attributed to differences in genetic susceptibility towards ionising radiation ( 26 , 27 , 28 , 29 , 30 , 31 , 32 ), activation of DNA repair ( 33 , 34 ), and anti-inflammatory processes ( 35 ). Lymphocyte chromosome aberrations in our occupationally exposed participants whose annual doses did not exceed risk limits can also be attributed to cumulative effects of chronic exposure to low-dose ionising radiation ( 36 ).…”

Section: Resultssupporting

confidence: 87%

Telomere fragility in radiology workers occupationally exposed to low doses of ionising radiation

Tričković

Šobot

Joksić³

et al. 2022

Archives of Industrial Hygiene and Toxicology

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Ionising radiation damages DNA directly and indirectly through increased production of reactive oxygen species. Although telomeres have been reported as indicators of radiosensitivity, their maintenance in response to occupational exposure to low radiation doses is still a matter of debate. In this work we aimed to investigate telomere length and structure in hospital workers occupationally exposed to X-rays and to relate these findings to oxidation of biomolecules and chromosome aberrations. Blood samples of exposed participants and matching controls were taken during periodical check-ups. Chromosome aberrations and telomere length and structure were analysed in peripheral blood lymphocytes using Q-FISH, whereas oxidative stress parameters [pro/antioxidant balance (PAB), lipid peroxidation, and 8-oxo-dG] were measured in plasma samples. Based on the CA findings we divided the exposed group into two subgroups, of which one had chromosome aberrations in the first division metaphases and the other did not. There was no significant difference in telomere length between any of the groups. However, both subgroups showed significantly higher rate of fragile telomeres and higher lipid peroxidation product and 8-oxo-dG levels than controls. The rate of fragile telomeres significantly correlated with plasma levels of 8-oxo-dG, which suggests that continuous exposure to low radiation doses induces oxidative base damage of guanine resulting in telomere fragility.

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Section: Resultssupporting

confidence: 87%

Telomere fragility in radiology workers occupationally exposed to low doses of ionising radiation

Tričković

Šobot

Joksić³

et al. 2022

Archives of Industrial Hygiene and Toxicology

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“…Improvement of practices and devices over time can influence exposure time. That is the reason why the mean annual effective doses has decreased during the period from 2007 to 2011 between Burkina Faso [8] and Nigeria [23]. However, we observe that in the year 2007, at the level of the diagnostic radiology sector, several countries presented the highest annual dose mean values [12,15,23].…”

Section: Discussionmentioning

confidence: 80%

“…The largest size of the source populations was 5152, provided in the field of diagnostic radiology by Ghana between 2000 and 2009. It was followed by Tanzania with 757 diagnostic radiology workers of 1000, while Tapsoba et al [8] reported only 81 medical workers of 157, in Ouagadougou at Burkina Faso. The different studies reported data on workers exposed to ionising radiation in all fields using ionising radiation, but more particularly in different specialities from medical sectors (table 2).…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

A systematic review of occupational radiation individual dose monitoring among healthcare workers exposed in Africa

et al. 2020

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Dosimetric monitoring is useful to limit exposures to ionising radiation in medical occupational settings, and reduce subsequent health risks. Scientific literatures, such as the UNSCEAR report 2017 and International Atomic Energy Agency Report 2014b, updated information on this subject; however, few African works have been found. This is the reason why we undertook this study, which summarises existing information on monitoring external radiation exposure doses for the whole body, using data from medical workers on this continent. Using standard terms and combining different keyword searches for radiation dose monitoring among radiology healthcare workers in Africa, from the titles, abstracts, and full texts, we found 3139 articles in the PubMed/MEDLINE, Google Scholar and INIS databases. Two reviewers screened the retrieved publications based on predefined eligibility criteria to identify relevant studies, extract key information from each, and summarise the data in table form. A total of 20 potentially relevant articles were identified. Among these 20 articles, 15 reported the overall average annual effective dose. Studies included in this systematic review represent an inventory of the radiation protection of medical workers in various African countries, with a focus on the monitoring of occupational radiation exposure. The size of studied populations ranged between 81 and 5152 occupational exposed workers. The mean annual effective doses ranged from 0.44 to 8.20 mSv in all specialities of medical sectors, while diagnostic radiology ranged from 0.07 to 4.37 mSv. For the nuclear medicine and radiotherapy from medical groups, the mean annual effective dose varied between 0.56 and 6.30 mSv. Industrial and research/teaching sectors data varied between 0.38 to 19.40 mSv. In conclusion, more studies implemented on dosimetric monitoring in Africa are needed to get a real picture of occupational exposure in the continent.

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“…This test is used in health surveillance to characterize the general health of the worker and, also can detect a variety of disorders such as infections, anemia, diseases of the immune system, and blood p. 4 PAG cancers. As a consequence of their radiosensitivity and high cell renewal rate (from hours to days), leukocytes and platelets are blood components that could characterize possible damage due to exposure to ionizing radiation [1,6,7]. However, the CBC test is not the most suitable biomarker, as it requires doses over the limits established as safe to exposed workers by international organizations to damage the components of peripheral blood [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Ten Years Evaluation of the Relationship Between the Individual Dose of Hospital Workers Occupationally Exposed to X-Rays and its Leukocyte and Platelet Counts of the CBC Tests

Lykawka,

Bacelar,

Dantas Filho

et al. 2024

Braz. J. Rad. Sci.

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The occupational health assessment of workers exposed to ionizing radiation is done through Complete Blood Count (CBC) tests in some countries, although studies have shown that this biomarker does not show evidence of exposition to low dose radiation. It is essential to analyze the radiation level doses of healthcare workers (HCW) exposed to X-rays in a university hospital and evaluate the association of this exposure on blood exam parameters. For this purpose, CBC tests and individual records of the X-rays exposure of 766 HCW were retrospectively evaluated from 2009 to 2019. Analyzing the annual and the monthly individual effective doses, no statistically significant relationship was identified with leukocyte count (b = -0.01 (95% CI, -0.03 - 0.01); p = 0.254) and (b = -0.04 (95% CI, -0.02 - 0.12); p = 0.606) respectively; nor for platelet count (b = -0.52 (95% CI, -1,09 - 0.05); p = 0.072) and (b = -0.69 (95% CI, -3.63 - 2.25); p = 0.646), respectively. Assessing the relationship between the monthly dose and the CBC tests, we found association with the leukocyte count (b = -0.12 (95% CI, -0.19 - -0.04); p = 0.002), but did not occur for platelet count (b = -1.91 (95% CI, -4.93 - 1.11); p = 0.215). The findings of the study demonstrated that there is no statistically significant relationship, with regard to clinical validity, between the individual effective doses and the leukocyte and platelet count in the CBC test in all analyses performed.

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Use of Biological Dosimetry for Monitoring Medical Workers Occupationally Exposed to Ionizing Radiation

Cited by 9 publications

References 66 publications

Telomere fragility in radiology workers occupationally exposed to low doses of ionising radiation

Telomere fragility in radiology workers occupationally exposed to low doses of ionising radiation

A systematic review of occupational radiation individual dose monitoring among healthcare workers exposed in Africa

Ten Years Evaluation of the Relationship Between the Individual Dose of Hospital Workers Occupationally Exposed to X-Rays and its Leukocyte and Platelet Counts of the CBC Tests

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