Use of biologics in rotator cuff disorders: Current concept review

Rohman, Lebur; Snow, Martyn

doi:10.1016/j.jcot.2021.05.005

Cited by 14 publications

(8 citation statements)

References 90 publications

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“…Many other factors contributing to treatment failure have been described, such as overload in the rehabilitation process, drugs (i.e., quinolones), alcohol intake, smoking, and corticosteroids [ 26 ]. There has been a growing interest in biologically active substances, such as growth factors, stem cells, and autologous conditioned serum [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

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Collagen and platelet-rich plasma in partial-thickness rotator cuff injuries. Friends or only indifferent neighbours? Randomised controlled trial

Godek¹,

Szczepanowska-Wołowiec

Golicki

2022

BMC Musculoskelet Disord

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Background Partial-thickness rotator cuff injuries (PTRCI) are the sum of degenerative, overload, and microtrauma processes. An external supply of collagen and platelet-rich plasma (PRP) could potentially counteract the deterioration of degenerative tendinopathy. This study aimed to compare the effectiveness of collagen with PRP, PRP alone, and collagen alone in the treatment of PTRCI. Methods Ninety patients with PTRCI were randomised and treated with ultrasound-guided injections into the shoulder bursa every consecutive week: Group A – collagen with PRP (n = 30), Group B – collagen alone (n = 30), and Group C – PRP alone (n = 30). Primary outcomes were pain intensity measured in control points on a numeric rating scale (NRS), QuickDash, and EQ-5D-5L questionnaires at the initial assessment (IA) and control assessments after 6 (T1), 12 (T2), and 24 (T3) weeks, respectively. Results No statistical differences were found between groups in primary outcomes, although there was a trend towards improvement in Groups A and C (opposite to Group B) between T2 and T3. The following parameters were also observed: rotator cuff discontinuity (n = 3, one case in each group) and rotator cuff regeneration (n = 22 in Group A, n = 20 in Group B, and n = 23 in Group C). Conclusions Combined therapy of collagen and PRP in PTRCI presents similar effectiveness to monotherapies with collagen or PRP. Trial registration The study was prospectively registered on the NCT Trial Center (identification number: NCT04492748) on 30.07.2020.

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Section: Discussionmentioning

confidence: 99%

“…7 Mean increase of width for BS and JS type of injury for specific groups. Abbreviations: RC rotator cuff, BS bursa-sided, JS joint-sided, IA initial assessment, T3 assessment after 24 weeks substances, such as growth factors, stem cells, and autologous conditioned serum [27].…”

Section: Discussionmentioning

confidence: 99%

Collagen and platelet-rich plasma in partial-thickness rotator cuff injuries. Friends or only indifferent neighbours? Randomised controlled trial

Godek¹,

Szczepanowska-Wołowiec

Golicki

2022

BMC Musculoskelet Disord

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“…For over two decades there have been a growing interest in biologically active substances like growth factors, stem cells or autologous conditioned serum [10].…”

Section: Discussionmentioning

confidence: 99%

Collagen and PRP in Partial Thickness Rotator Cuff Injuries. Friends or Only Indifferent Neighbours? Randomized Controlled Trial

Godek¹,

Szczepanowska-Wołowiec²,

Golicki³

2021

Preprint

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INTRODUCTION: Partial thickness rotator cuff injuries (PTRCI) is the sum of degenerative, overload and microtrauma processes, external supply of collagen and platelet-rich plasma (PRP) could potentially counteract deterioration of degenerative tendinopathy.AIM: Comparison of the effectiveness: collagen with PRP, PRP alone, collagen alone in the treatment of PTRCI.METHODS: Ninety patients with PTRCI treated with US–guided injections into the shoulder bursa every consecutive week: Group A - collagen with PRP (n=30), B - collagen alone (n=30), C - PRP alone (n=30). Primary outcomes: numeric rating scale (NRS), QuickDash and EQ-5D-5L questionnaires in control points: IA (initial assessment), T1, T2, T3 – after 6, 12 and 24 weeks, respectively. Secondary outcomes: number of patients with loss of RC continuity, number of regenerated RC between IA and T3.RESULTS: No statistical difference between groups in primary outcomes, tendency for further improvement in A and C group (opposite to group B) between T2 and T3. The RC discontinuity (n = 3, one case in each group) and RC regeneration (n = 65; 73%, 67% and 77%, in group A, B and C, respectively).CONCLUSIONS: Combined therapy of collagen and PRP in PTRCI is not more effective than monotherapies with collagen or PRP. (clinicaltrials.gov - NCT04492748)

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“…There are most certainly some cases where conservative treatment is an option. People with partial tears of the rotator cuffs or those with rotator cuffs that appear to be intact but inflamed are likely to benefit from surgical intervention [7]. According to the results of the imaging of the shoulder, depending on the accuracy of the diagnosis of the extent of the rotator cuff tear, as well as whether the decision to proceed with conservative management or to undergo surgery will be made, the results of the imaging could have clinical implications [8].…”

Section: Introductionmentioning

confidence: 99%