Use of bioreporters and deletion mutants reveals ionic silver and ROS to be equally important in silver nanotoxicity

Joshi, Nimisha; Ngwenya, Bryne T.; Butler, Ian B.; French, Christopher E.

doi:10.1016/j.jhazmat.2014.12.066

Cited by 36 publications

(16 citation statements)

References 38 publications

(54 reference statements)

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“…In contrast, Joshi et al. did not observe the increase of the intracellular Ag + concentration upon exposure to AgNPs using a bioluminescent E. coli strain, as bacteria died before Ag + could be measured . Hsueh et al.…”

Section: Ag As An Antimicrobial Agentmentioning

confidence: 95%

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Handling (Nano)Silver as Antimicrobial Agent: Therapeutic Window, Dissolution Dynamics, Detection Methods and Molecular Interactions

Abram

Fromm

2020

Chemistry A European J

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Silver is an antimicrobial agent well known since antiquity. With the emergence of multiresistant bacteria, it has come back into the focus of research, and ionic as well as nano‐sized silver have been studied in vitro and in vivo. The results are controversial, silver being discussed as the “silver bullet” or a “wolf in sheep's clothing”. A thorough search of literature from chemistry, materials and environmental science, biology and medicine led to this Review which summarizes the potential use of silver and its compounds in medicine, ongoing processes of dissolution and the different methods by which this usefulness can be evaluated. It also highlights the therapeutic window of silver, mechanistic interactions of silver and biological media as well as best practices for handling silver in a biomedical environment. This Review reflects the current knowhow and observations, and may thus give hints and guidelines to understand and interpret the observed effects.

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Section: Ag As An Antimicrobial Agentmentioning

confidence: 95%

“…For fluorescence detection of intracellular Ag + in prokaryotic cells, genetically modified bioreporter E. coli strains have been developed that exhibit bioluminescence selectively in presence of Ag + . They give a linear response to intracellular Ag + in the sublethal concentration range …”

Section: Ag As An Antimicrobial Agentmentioning

confidence: 99%

Handling (Nano)Silver as Antimicrobial Agent: Therapeutic Window, Dissolution Dynamics, Detection Methods and Molecular Interactions

Abram

Fromm

2020

Chemistry A European J

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“…AgNPs induce the higher concentration of hydrogen peroxide (H 2 O 2 ), superoxide anion (O 2 − •) and hydroxyl radical (OH•) inside bacterial cell [ 52 , 58 , 59 ]. The detailed mechanism is still not well known but superoxide is predicted to be the major ROS in this process [ 52 , 60 ]. AgNPs disturb the function of the respiratory chain in the cell resulting in ROS generation.…”

Section: Mode Of Antibacterial Action Of Silver (Moa)mentioning

confidence: 99%

Similarities and Differences between Silver Ions and Silver in Nanoforms as Antibacterial Agents

Kędziora

Speruda

Krzyżewska

et al. 2018

IJMS

368

290

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Silver is considered as antibacterial agent with well-known mode of action and bacterial resistance against it is well described. The development of nanotechnology provided different methods for the modification of the chemical and physical structure of silver, which may increase its antibacterial potential. The physico-chemical properties of silver nanoparticles and their interaction with living cells differs substantially from those of silver ions. Moreover, the variety of the forms and characteristics of various silver nanoparticles are also responsible for differences in their antibacterial mode of action and probably bacterial mechanism of resistance. The paper discusses in details the aforementioned aspects of silver activity.

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“…Although one hypothesis emphasizes the role of silver ions released from the surfaces of AgNPs inside bacterial cells [53,82], direct action of AgNPs on microorganisms has also been proposed [64].…”

Section: Toxic Effects Of Agnps In Microorganismsmentioning

confidence: 99%

“…Moreover, both forms of silver may interact with bacterial DNA and prevent DNA replication and cell division, leading to cell death [34,125]. Another mechanism of antibacterial action induced by AgNPs is generation of reactive oxygen species, which damage all components of the cell, including cell membranes and DNA [64,72].…”

Section: Toxic Effects Of Agnps In Microorganismsmentioning

confidence: 99%

Toxic effects of silver nanoparticles in mammals – does a risk of neurotoxicity exist?

Skalska¹,

Strużyńska²

2015

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A b s t r a c t Over the last decade, silver nanoparticles have become an important class of nanomaterials utilized in the development of new nanotechnologies. Despite the fact that nanosilver is used in many commercial applications, our knowledge about its associated risks is incomplete. Although a number of studies have been undertaken to better understand the impact of silver nanoparticles on the environment, aquatic organisms and cell lines, little is known about their side effects in mammalian organisms. This review summarizes relevant data and the current state of knowledge regarding toxicity of silver nanoparticles in mammals, as well as the accumulated evidence for potent neurotoxic effects. The influence of nanosilver on the central nervous system is significant because of evidence indicating that it accumulates in mammalian brain tissue.

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Use of bioreporters and deletion mutants reveals ionic silver and ROS to be equally important in silver nanotoxicity

Cited by 36 publications

References 38 publications

Handling (Nano)Silver as Antimicrobial Agent: Therapeutic Window, Dissolution Dynamics, Detection Methods and Molecular Interactions

Handling (Nano)Silver as Antimicrobial Agent: Therapeutic Window, Dissolution Dynamics, Detection Methods and Molecular Interactions

Similarities and Differences between Silver Ions and Silver in Nanoforms as Antibacterial Agents

Toxic effects of silver nanoparticles in mammals – does a risk of neurotoxicity exist?

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