2023
DOI: 10.3390/biom13030512
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Use of Botulinum Toxin for Limb Immobilization for Rehabilitation in Rats with Experimental Stroke

Abstract: Motor rehabilitation strategies after unilateral stroke suggest that the immobilization of the healthy, unimpaired limb can promote the functional recovery of a paretic limb. In rodents, this has been modeled using casts, harnesses, and other means of restricting the use of the non-paretic forelimb in models of experimental stroke. Here, we evaluated an alternative approach, using botulinum toxin injections to limit the function of the non-paretic forelimb. Adult male rats were subjected to permanent ligation … Show more

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