Use of cabergoline for oestrus induction in multiparous anoestrous Beagle bitches

Shimatsu, Yoshiki

doi:10.1111/avj.12622

Cited by 4 publications

(8 citation statements)

References 14 publications

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“…As shown for the efficacy regarding oestrous induction, the pregnancy rate is influenced by the stage of anestrus, in which the treatment is performed with better results if treatment takes place in late anestrus. Pregnancy rates of 70% to 100% have been obtained after oestrous induction using dopamine agonists (Ajitkumar et al., ; Cirit et al., ; Gobello, Castex, & Corrada, ; Günay, Günay, & Soylu, ; Shimatsu, ; Verstegen et al., ; Zöldág, Fekete, Csáky, & Bersényi, ). In a recent study, the administration of oestradiol benzoate (unauthorized in many countries due to severe side effects), 1 week before the start of cabergoline treatment, led to significant reduction of the time span until the onset of proestrus and showed a synchronizing effect.…”

Section: Oestrous Induction Options Mechanisms Of Action and Side Efmentioning

confidence: 99%

Manipulation of the oestrous cycle of the bitch—what works… for now

Maenhoudt

Santos

Fontbonne

2018

Reprod Domestic Animals

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Contents Manipulation of the oestrous cycle of the bitch is a common request of pet owners for different reasons. On one side, clients may be interested in temporally preventing oestrus until the bitch has finished the performance career, or to manage the kennel in the presence of a stud dog and to avoid undesirable breeding. Additionally, clients with no interest to use their animal for breeding, may, for ethical reasons, prefer to avoid elective surgery such as ovariectomy, to control reproduction. On the other side, clients may want to induce oestrus to better control the time of birth, to use a male with limited availability during a specific time, or to reduce the duration of the interoestrous interval in bitches with a long oestrous cycle (>8 months). Both these options for oestrous manipulation are based on hormonal treatments. For oestrous prevention, synthetic progesterone has been used since the 1960s. Induction of oestrus has been established with reliable results using dopamine agonists in the late 1980s and more recently using GnRH agonists. This review is focusing on the current and recently available treatments to manipulate the oestrous cycle in the bitch.

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Section: Oestrous Induction Options Mechanisms Of Action and Side Efmentioning

confidence: 99%

Manipulation of the oestrous cycle of the bitch—what works… for now

Maenhoudt

Santos

Fontbonne

2018

Reprod Domestic Animals

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“…11 The study used 20 Beagle bitches: group 1 compared five early anoestrus bitches and five mid-anoestrus bitches; group 2 compared five mid-anoestrus bitches with five bitches that had been pregnant in the previous cycle. This study built on previous studies that used dopamine agonists and looked at the use of cabergoline, which binds specifically to hypothalamic and pituitary dopamine receptors.…”

Section: Small Animalsmentioning

confidence: 99%

“…This study built on previous studies that used dopamine agonists and looked at the use of cabergoline, which binds specifically to hypothalamic and pituitary dopamine receptors. 11 The study used 20 Beagle bitches: group 1 compared five early anoestrus bitches and five mid-anoestrus bitches; group 2 compared five mid-anoestrus bitches with five bitches that had been pregnant in the previous cycle. Both groups were given cabergoline and mating occurred following the LH surge.…”

Section: Small Animalsmentioning

confidence: 99%

In this issue – September 2017

Jackson¹

2017

Aust Veterinary J

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“…The second treatment category is the direct stimulation of the pituitary with gonadotropin-releasing hormone (GnRH), in which lutrelin, buserelin, deslorelin, and leuprolide are used [8,16,20,21]. The third category is shortening the length of anestrus by suppressing the synthesis or release of prolactin (PRL) using a dopamine agonist [6,13,20,29,35].…”

Section: Introductionmentioning

confidence: 99%

“…Cabergoline, a dopamine agonist, is known to suppress PRL to induce estrus in bitches [6,13,20,29,35].…”

Section: Introductionmentioning

confidence: 99%

Changes in luteinizing hormone pulse frequency and prolactin levels in bitches in response to estrus induction by cabergoline-its cases where it is delayed to induce estrus

Ohtaki

Fujiwara

Watanabe

et al. 2020

The Journal of Veterinary Medical Science

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The effect of estrus induction by cabergoline on gonadotropin and steroid hormone responses was examined in anestrous bitches. Eleven beagles were used in the study; seven were included in the estrus induction group and four were included in the spontaneous estrus group. Cabergoline was orally administered to the estrus induction group at 5 µg/kg once daily for four weeks, or until hemorrhagic discharge was detected. The interestrus interval in the estrus induction group was significantly shorter than the previous estrus interval. Bitches that showed proestrus within four weeks of treatment showed increased luteinizing hormone (LH) pulse frequency and, subsequently, increased estradiol (E2) levels. Prolactin (PRL) levels declined promptly after treatment, except in one bitch that did not show proestrus during the cabergoline treatment period. There was a significant correlation between the time to proestrus induction and the reduction in PRL levels. A positive correlation was found between the LH levels two weeks after cabergoline administration and PRL reduction.This study demonstrates that an abrupt reduction in PRL is likely to be important for initiation of estrus in bitches. A reduction in PRL indirectly leads to an increase in LH pulse frequency, which regulates follicular development in bitches. However, if the period from the end of the previous estrus to the cabergoline treatment is short, it may take some time to show proestrus without increasing E2 levels, even if the LH level increases after cabergoline administration.

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Use of cabergoline for oestrus induction in multiparous anoestrous Beagle bitches

Abstract: Cabergoline is effective for oestrus induction in mid-anoestrus bitches.

Cited by 4 publications

References 14 publications

Manipulation of the oestrous cycle of the bitch—what works… for now

Manipulation of the oestrous cycle of the bitch—what works… for now

In this issue – September 2017

Changes in luteinizing hormone pulse frequency and prolactin levels in bitches in response to estrus induction by cabergoline-its cases where it is delayed to induce estrus

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