Use of Cardiac Glycosides in Finland

Impivaara, Olli

doi:10.1111/j.0954-6820.1985.tb06126.x

Journal of Internal Medicine

1985

DOI: 10.1111/j.0954-6820.1985.tb06126.x

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Use of Cardiac Glycosides in Finland

Olli Impivaara

Abstract: lmpivaara 0. (Rehabilitation Research Centre of the Social Insurance lnstitution, Turku, Finland.) Use of cardiac glycosides in Finland. Acta Med Scand 1985; 218: 285-92.The prevalence and number of persons receiving cardiac glycosides were estimated in connection with a general health survey. A population sample (n=8000) representative of the adult Finnish population was studied. According to a questionnaire and an interview, about 10% of men and 11 % of women were receiving cardiac glycosides. The total numb… Show more

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Cited by 5 publications

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Drug utilization by the 30–64 year-old people in two cities in the Federal Republic of Germany in 1984

Tennis

1990

Eur J Clin Pharmacol

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A study has been done to describe and compare the drug utilization profiles of the 30-64 yr-old populations in two cities in the Federal Republic of Germany. Subjects from two community surveys, based on random samples in 1984, from the communities of Augsburg in the south, and Luebeck in the north, were asked to bring to interview any medications taken in the preceding seven days. Total drug use in the two communities was very similar. Women took more drugs than men. The drug categories used by at least 5% of men were analgesics/antirheumatics and antihypertensives. The prevalence of use of different drug categories by men was remarkably similar in the two cities, and the only significant difference was a greater consumption of antihypertensive drugs by Luebeck men (9.8%) compared to Augsburg men (6.3%). The drugs taken by at least 5% of women were sex hormones, analgesics/antirheumatics, antihypertensives, thyroid preparations, psychotropics, cardiac drugs and antihypotensives. Consumption by Augsburg women was significantly greater for sex hormones, cardiac drugs, thyroid drugs, and migraine drugs, whereas Luebeck women consumed significantly more antihypertensives. The high use of thyroid drugs by Augsburg women (11%) is indicative of the high frequency of endemic goitre in the southeastern quarter of the FRG. Although it has been shown from sales data that the FRG has a high consumption of cardiac glycosides, the 6% prevalence of use of preparations of them by 30-64 yr-old Augsburg women represents more precise exposure information and reflects a relatively young group of users.

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Drug utilization by the 30–64 year-old people in two cities in the Federal Republic of Germany in 1984

Tennis

1990

Eur J Clin Pharmacol

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Subchronic treatment with vanadate does not potentiate the toxicity of cardiac glycosides

MacDonald

Lihtamo

Hellevuo

et al. 1988

Biol Trace Elem Res

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Since it has been claimed that vanadate is an endogenous regulator of Na/K-ATPase activity and that it potentiates the toxicity of cardiac glycosides, we were alarmed to discover that certain Finnish physicians were prescribing vanadate in combination with other trace minerals to elderly patients for many different chronic diseases (e.g., cancer, rheumatism). To study the interaction of vanadate and cardiac glycosides, we fed vanadate in the drinking water (25 micrograms/mL) to guinea pigs for 20 d, and studied either their sensitivity to the acute toxicity of the cardiac glycoside ouabain or whether the vanadate would influence the subacute toxicity of ouabain. Vanadate had no influence on the toxicity of ouabain either acute or subchronically administered, nor was there any sign of inhibition of Na/K-ATPase activity as measured by 86Rb-uptake into intact erythrocytes (RBCs), RBC content of sodium or potassium or Na/K-ATPase activity in RBC membranes prepared from the vanadate-treated guinea pigs. Vanadate had been absorbed in substantial quantities from the gastrointestinal tract, since serum, heart, liver, and especially kidney contained measurable amounts of vanadium in contrast to controls, but it is concluded that this vanadate is not in a biologically active form.

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Overprescription and Underprescription of Digitalis

Impivaara

Iisalo

Aromaa

et al. 1986

Journal of Internal Medicine

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ABSTRACT. As part of a health examination of a representative sample (n= 8000) of the adult Finnish population, cardiac state was assessed in the 747 digitalis users and the 6329 non‐users who participated in the survey. Ninety per cent of the digitalis users were in sinus rhythm and 50% were in sinus rhythm and had a normal roentgenographic heart volume. About 20% of those in sinus rhythm had a normal heart volume and a “subtherapeutic” serum digitalis concentration. The age‐adjusted prevalence of digitalis therapy in the presence of sinus rhythm was 8% in men and 10% in women. The total number of these patients in Finland was estimated at 246 000 (95% confidence limits 225 000–267 000). Half of the men and two thirds of the women on digitalis received concomitant diuretic therapy. Atrial fibrillation and/or markedly enlarged heart were observed in 1.5% of the men and 0.9% of the women not receiving digitalis. Their total number in the Finnish population was estimated at 23 000 (±7000). The results suggest that questionable digitalis therapy is very common since several authors have reported successful withdrawal of maintenance digitalis therapy in at least half of the patients in sinus rhythm. On the other hand, underprescription of digitalis seems to be uncommon.

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Use of Cardiac Glycosides in Finland

Cited by 5 publications

References 11 publications

Drug utilization by the 30–64 year-old people in two cities in the Federal Republic of Germany in 1984

Drug utilization by the 30–64 year-old people in two cities in the Federal Republic of Germany in 1984

Subchronic treatment with vanadate does not potentiate the toxicity of cardiac glycosides

Overprescription and Underprescription of Digitalis

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