Use of Catridecacog in a Patient with Severe Factor XIII Deficiency Undergoing Surgery

Abstract

Despite many articles regarding the antihemorrhagic treatment and prophylaxis, there is a lack of experience about how to best conduct major surgical procedures in patients with congenital factor XIII (FXIII) deficiency. Here we report a case of surgery (right inguinal hernia, complicated by heaviness and pain) performed in a patient with FXIII deficiency, receiving recombinant FXIII prophylaxis (Catridecacog 35 UI/kg every 28±2 days). Our experience shows that Catridecacog can be used safely and effectively not only for continued prophylaxis but also in surgery and adds to the very limited body of evidence currently available on surgery in this bleeding disorder.

Factor XIII deficiency leading to preseptal haematoma post-strabismus surgery

“…This is available in the form of plasma-derived FXIII, that is, cryoprecipitates and fresh frozen plasma 5. However, recently various reports of using recombinant FXIII has been published achieving successful haemostasis 6 7. To our knowledge, only a single case of bilateral intraorbital haemorrhage after strabismus surgery in FXIII deficiency has been reported in the literature, which is currently unavailable in India 8.…”

Massive Delayed Bleeding after Breast Reconstruction Caused by Acquired Factor XIII Deficiency

“…However, the factor XIII content of 1 mL cryoprecipitate is too low to prevent bleeding 9) . A study reported the presence of α-subunit mutation and congenital factor XIII activity level under 5%, in which a dose of 35 units/ kg recombinant factor XIII (NovoThirteen ® , 2500 units/vial; Novo Nordisk, Bagsvaerd, Denmark) was considered suitable and safe 10) .…”