Use of chemical characteristics to predict the relative bioavailability of supplemental organic manganese sources for broilers1

Li, S.; Luo, Xin; Liu, B.; Crenshaw, T. D.; Kuang, Xingya; Shao, Gu; Yu, Shuang

doi:10.2527/2004.8282352x

Cited by 90 publications

(157 citation statements)

References 26 publications

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“…The activity of both forms of SOD reached normal levels when a Mn-supplemented (1,000 ppm) diet was fed to deficient chickens, but the activity of the manganese enzyme was not affected by feeding the supplemented diet to manganese sufficient chickens. It was shown that heart Mn-SOD activity and heart Mn-SOD mRNA levels increased linearly as dietary Mn levels increased, confirming that dietary Mn significantly affected heart Mn-SOD gene transcription [80]. Furthermore, birds fed supplemental Mn had lower MDA content in leg muscle and greater Mn-SOD activities and Mn-SOD mRNA level in breast or leg muscle than those fed the control diet [81].…”

Section: Dietary Modulation Of Sod Mn and Cu In The Dietmentioning

confidence: 73%

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

Surai¹

2016

J Anim Res Nutr

168

135

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Commercial poultry production is associated with various stresses responsible for decreasing productive and reproductive performance of growing chicks, breeders and commercial layers. A growing body of evidence shows that most of stresses in poultry production at the cellular level are associated with oxidative stress. Recently, a concept of the cellular antioxidant defense has been revised with special attention paid to cellular redox status maintenance and cell signaling. In fact, antioxidant systems of the living cell are based on three major levels of defense and superoxide dismutase (SOD) is shown to belong to the first level of the antioxidant defense network. Cellular antioxidant defenses are shown to include several options and vitagene activation in stress conditions is considered as a fundamental adaptive mechanism. The vitagene family includes various genes regulating synthesis of protective molecules including thioredoxins, sirtuins, heat shock proteins and SOD. However, by the time of writing no comprehensive review on the roles and effects of SOD in poultry biology has appeared. Therefore, the aim of this review is a critical analysis of the role of SOD in poultry biology with specific emphasis to its functions as an essential part of the vitagene network. From the analysis of the recent data related to SOD in poultry physiology and adaptation to stresses it is possible to conclude that: a) SOD as important vitagene is the main driving force in cell/body adaptation to various stress conditions. Indeed, in stress conditions additional synthesis of SOD is an adaptive mechanism to decrease ROS formation; b) If the stress is too high SOD activity is decreased and apoptosis is activated; c) there are tissue-specific differences in SOD expression which also depends on the strength of such stress-factors as heat, heavy metals, mycotoxins and other stressors; d) SOD is shown to provide an effective protection against lipid peroxidation in chicken embryonic tissues and semen; e) SOD is shown to be protective in heat and cold stress, toxicity stress as well as in other oxidative-stress related conditions in poultry production; f) there are complex interactions inside the antioxidant network of the cell/body to ensure an effective maintenance of homeostasis in stress conditions. Indeed, in many cases, nutritional antioxidants (vitamin E, selenium, carotenoids, phytochemicals, etc.) in the feed can increase SOD expression; g) nutritional means of SOD upregulation in stress conditions of poultry production and physiological and commercial consequences await further investigation; h) vitagene upregulation in stress conditions is emerging as an effective means for stress management.

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Section: Dietary Modulation Of Sod Mn and Cu In The Dietmentioning

confidence: 73%

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

Surai¹

2016

J Anim Res Nutr

168

135

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“…The discrepancies in relative bioavailability between various organic Mn sources could be explained by different chemical characteristics and chelation strength of commercial organic Mn feed additives (Li et al, 2004). Gravena et al (2011) observed an increase in the Mn content of egg yolk from quails supplemented with 60, 120, and 180 mg Mn/kg feed from an organic source.…”

Section: Discussionmentioning

confidence: 99%

Effects of feed supplementation with manganese from its different sources on performance and egg parameters of laying hens

Venglovská¹,

Grešaková²,

Plachá³

et al. 2014

CZECH J ANIM SCI

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ABSTRACT:The objective of this study was to compare the effects of feed supplementation of laying hens with manganese from its inorganic and organic sources on performance and some parameters of egg quality. Ninety-six hens at 20 weeks of age were randomly allocated to 4 dietary treatments, each consisting of 6 replicates (4 birds per replicate). The control group was fed unsupplemented basal diet (BD) with only natural background Mn level of 46.4 mg/kg feed. For the three experimental treatments, the BD was supplemented with 120 mg Mn/kg either from Mn-sulphate or Mn-chelate of protein hydrolysate (Mn-Pro) or Mn-chelate of glycine hydrate (Mn-Gly). After 8 weeks of dietary treatments the egg production, egg weight, feed intake, and feed efficiency were not affected by dietary treatments. Regardless of the sources, Mn supplementation to feed resulted in significantly decreased percentages of cracked eggs compared to the unsupplemented control group. The thickness, weight, proportion, and index of eggshell were significantly elevated in all groups supplemented with Mn. The intake of Mn-Gly resulted in considerably increased Mn deposition in egg yolk compared to the control eggs. In the control and Mn-sulphate groups yolk malondialdehyde (MDA) started to increase after 20 and 30 days of egg storage respectively, whereas in eggs from hens given organic Mn-sources this parameter was not affected up to 40 days. Although there were no significant differences in MDA values between the treatments until 20 days of storage, the Mn-sulphate group showed significantly higher MDA concentration in yolks compared to the control group after 30 days of storage. These results demonstrate that supplementation of hens' diet with Mn has positive effects on eggshell quality. Feed supplementation with Mn from organic sources appears to be more effective in preventing yolk lipid oxidation during cold storage of eggs than that from Mn-sulphate.

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“…analysed to be 61·9, which was categorised as a moderate chelation strength based on the classification of Li et al (13) .…”

Section: Resultsmentioning

confidence: 99%

“…Mn is a crucial component of the metalloenzyme manganese superoxide dismutase (MnSOD) (9) , which has a key role in the detoxification of superoxide free radicals. A series of studies in our laboratory have demonstrated that dietary Mn may increase heart MnSOD activity and reduce lipid peroxidation in broilers (10,11) and commercial laying hens (12) , as well as up-regulate heart MnSOD expression (13)(14)(15)(16) in broilers under * Corresponding author: X.-G. Luo, fax +86 10 62810184, email wlysz@263.net † These authors contributed equally to the present work.Abbreviations: CON, Mn-unsupplemented basal diet; CuZnSOD, copper zinc superoxide dismutase; HSF1 and HSF3, heat-shock factors 1 and 3; HSP70 and HSP90, heat-shock proteins 70 and 90; HT, high temperature; iMn, basal diet supplemented with 120 mg Mn/kg as inorganic Mn; MDA, malondialdehyde; MnSOD, manganese superoxide dismutase; NT, normal temperature; oMn, basal diet supplemented with 120 mg Mn/kg as organic Mn; ROS, reactive oxygen species; SOD, superoxide dismutase. …”

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confidence: 97%

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confidence: 99%

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Effect of dietary manganese on antioxidant status and expression levels of heat-shock proteins and factors in tissues of laying broiler breeders under normal and high environmental temperatures

Zhu

Lü

et al. 2015

Br J Nutr

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To investigate the effect of Mn on antioxidant status and expression levels of heat-shock proteins/factors in tissues of laying broiler breeders subjected to heat challenge, we used a completely randomised design (n 6) with a factorial arrangement of 2 environmental temperatures (normal, 21 (SEM 1)°C and high, 32 (SEM 1)°C) × 3 dietary Mn treatments (an Mn-unsupplemented basal diet (CON), or a basal diet supplemented with 120 mg Mn/kg diet as inorganic Mn sulphate (iMn) or organic Mn proteinate (oMn)). There were no interactions (P > 0·10) between environmental temperature and dietary Mn in all of the measured indices. High temperature decreased (P < 0·003) Mn content, and also tended (P = 0·07) to decrease copper zinc superoxide dismutase (CuZnSOD) activity in the liver and heart. However, an increased manganese superoxide dismutase (MnSOD) activity (P < 0·05) and a slight increase of malondialdehyde level (P = 0·06) were detected in breast muscle. Up-regulated (P < 0·05) expression levels of heat-shock factor 1 (HSF1) and HSF3 mRNA and heat-shock protein 70 (HSP70) mRNA and protein were found in all three tissues. Broiler breeders fed either iMn or oMn had higher tissue Mn content (P < 0·0001), heart MnSOD and CuZnSOD activities (P < 0·01) and breast muscle MnSOD protein levels (P < 0·05), and lower (P < 0·05) breast muscle HSP70 mRNA and protein levels than those fed CON. Broiler breeders fed oMn had higher (P < 0·03) bone Mn content than those fed iMn. These results indicate that high temperature decreases Mn retention and increases HSP70 and HSF1, HSF3 expression levels in tissues of laying broiler breeders. Furthermore, dietary supplementation with Mn in either source may enhance heart antioxidant ability and inhibit the expression of HSP70 in breast muscle. Finally, the organic Mn appears to be more available than inorganic Mn for bone in laying broiler breeders regardless of environmental temperatures.Key words: Broiler breeders: Manganese: Heat stress: Antioxidant status: Heat-shock proteins/factorsThe effect of heat stress on productive performance has been extensively studied in poultry, especially in high-producing hens (1)(2)(3)(4) . High environmental temperature negatively influences the performance of laying commercial hens (1,2) and broiler breeders (3,4) by reducing feed intake, egg production and eggshell quality. In addition to altered productive performance, heat stress can also disturb the redox balance and induce oxidative stress, with the production of reactive oxygen species (ROS), in broiler breeders (5) and commercial hens (6) . Although substantial attention has been paid to the roles of antioxidant trace minerals (Se, Zn) in minimising the harmful effect of heat stress in broilers (7) and commercial laying hens (8) , the role of Mn in stress reduction has not been well studied. Mn is a crucial component of the metalloenzyme manganese superoxide dismutase (MnSOD) (9) , which has a key role in the detoxification of superoxide free radicals. A series of studies in our laboratory...

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Use of chemical characteristics to predict the relative bioavailability of supplemental organic manganese sources for broilers1

Cited by 90 publications

References 26 publications

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

Effects of feed supplementation with manganese from its different sources on performance and egg parameters of laying hens

Effect of dietary manganese on antioxidant status and expression levels of heat-shock proteins and factors in tissues of laying broiler breeders under normal and high environmental temperatures

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