Background Currently, conventional placement of natural pressure drainage after single-level anterior cervical discectomy with fusion and plating (ACDF) is used clinically to prevent complications such as symptomatic epidural hematoma and incision infection. Nevertheless, a literature review reported that there is no uniform standard for whether to place drainage after single-level ACDF surgery, and comparative studies on this subject are rare.Methods A prospective study of 100 patients who underwent single-level ACDF from January 2017 to June 2018 and met the selection criteria were randomly divided into the control group (45 patients with drainage after surgery) and the study group (48 patients without drainage after surgery). The same types of preoperative preparation, surgical technique and postoperative management were used in the two groups. The perioperative indicators, postoperative clinical efficacy and complications were compared between the two groups.Results The preoperative and postoperative Japanese Orthopaedic Association (JOA) scores, Visual Analogue Scale (VAS) scores and Neck Dysfunction Index (NDI) scores in the two groups were significantly different (P < 0.05). The length of hospital stay in the study group was significantly shorter than that in the control group (P < 0.05). There were no significant differences in postoperative fever, surgical site infection, symptomatic epidural hematoma, rate of incision healing, or complications between the two groups (P>0.05).Conclusions The safety and clinical outcome of patients with drainage after single-level ACDF were consistent with those of nondrainage patients. Additionally, nondrainage after single-level ACDF resulted in a decreased length of hospital stay and lessened the associated expenses.