A novel technique for non-destructive assay (NDA) of radioactive waste called ARCTERIX (Advanced Radwaste Characterisation based on Tomographically Enhanced Radiation Imaging without X-rays) is presented. The concept is based on a 3D-tomographic imaging technique for special nuclear materials – neutron-gamma emission tomography (NGET). ARCTERIX takes the NGET principle from its original application area of nuclear security systems into the realm of radioactive waste assay with its special characteristics and challenges. By adding localisation and imaging of SNM inside shielded waste containers to the array of existing techniques used for radioactive waste characterisation, ARCTERIX complements the state of the art in passive and active NDA interrogation methods. It is aimed primarily at the class of mixed, long-lived radioactive waste that is commonly called “legacy” or “historic” waste which has special safety, security and safeguards concerns due to its mixed composition, commonly poor documentation, and the frequent presence of SNM. The ARCTERIX concept provides rapid imaging and characterisation of nuclear materials in radioactive waste with a high degree of automation and high throughput capabilities, making it possible to quickly scan large radioactive waste inventories for the presence of special nuclear materials with minimal manual intervention. The first ARCTERIX prototype system has demonstrated a high technological readiness for the implementation of the technique in a commercial stand-alone system for rapid assessment of radioactive waste drums or in a system operating in conjunction with established techniques.