Use of cohort data to estimate national prevalence of transmitted drug resistance to antiretroviral drugs in Spain (2007–2012)

Abstract

Prevalence of transmitted drug resistance (pTDR) to antiretroviral drugs in Spain (2007-2012) was estimated using the CoRIS cohort, adjusting its territorial distribution and transmission route to the reference population from the Spanish Information System on New human immunodeficiency virus diagnoses. A total of 2702 patients from ten autonomous communities and with naive FASTA sequence within 6 months of human immunodeficiency virus diagnosis were selected. Weighted pTDR, estimated using the inverse probability of selection in the sample by autonomous communities and transmission group, was 8.12% (95% CI 6.44-9.80), not significantly different from unweighted pTDR. We illustrate how proportional weighting can maximize representativeness of cohort-based data, and its value to monitor pTDR at country level.

Transmitted drug resistance to antiretroviral drugs in Spain during the period 2019–2021

“…As expected, and as it is also happening globally, NNRTI-SDRM are at the highest levels of TDR, and in our opinion could be infraestimated, as an update of SDRM for this family including specific rilpivirine and doravirine mutations may be urgently needed. 28 In this study, as in previous papers, conducted in Europe and Spain 2,[29][30][31][32] in addition to TDR, we have analyzed TCRR, which may result in a more accurate estimate for the choice of clinicians on the first-line regimen. To evaluate the clinical resistance, we used the Stanford algorithm.…”

“…In this study, as in previous papers, conducted in Europe and Spain 2,29–32 in addition to TDR, we have analyzed TCRR, which may result in a more accurate estimate for the choice of clinicians on the first‐line regimen. To evaluate the clinical resistance, we used the Stanford algorithm.…”

“…First, CoRIS is an open cohort of PLWH in Spain in which different centers of the autonomous communities of Spain participate but during the COVID pandemic it was very difficult for all centers to continue with the usual care routine, and therefore the number of sequences in 2020 and 2021 was lower. Second, the design of our study was heterogeneous, as we have collected data from routine resistance tests in newly diagnosed PLWH from different autonomous communities, with diverse sampling methods and representativeness in the country; however, as shown in previous studies from our group, CORIS is fully representative of the Spanish HIV epidemic 32 . Finally, a small subset of the integrase fasta sequences provided by certain participating centers were acquired using next generation sequencing assays that did not cover positions 230 and 263.…”

Are European HIV cohort data within EuroCoord representative of the diagnosed HIV population?

“…Older individuals also tended to be underrepresented in some cohorts. Results from previous studies are conflicting, reporting either higher or lower probability of inclusion for older individuals [5,22]. However, it has been reported previously that older age is significantly associated with late diagnosis [23].…”

Summary of Presentations from the International Workshop on Antiviral Drug Resistance: Meeting the Global Challenge, 3–7 June 2014, Berlin, Germany

“…Clinical interpretation guidelines are needed to assist clinicians and researchers to make the best use of these new data. Nonetheless, as evidenced by the number of additional poster abstracts related to TDR using conventional techniques [23][24][25][26][27][28][29][30][31], there remains considerable interest and utility in the use of these methods for surveillance purposes.…”