“…It affects up to 20% of confirmed pregnancies, and approximately 50% of cases end in pregnancy loss [1][2][3]. Even if the miscarriage is avoided, women who suffer from threatened miscarriage remain at high risk for adverse pregnancy outcomes such as premature birth, antepartum hemorrhage, low birth weight, and neonatal death, as well as psychological anomalies [4][5][6][7][8], and thus threatened miscarriage is a physically and psychologically traumatic experience for women and their families. Many factors cause threatened miscarriage, including chromosomal defects, immunological dysfunction, maternal thrombophilic disorders, endocrine abnormalities, and uterine structural anomalies.…”