Use of cryopoor plasma for albumin replacement and continuous antimicrobial infusion for treatment of septic peritonitis in a dog

Abstract

This case includes novel techniques such food dye via nasogastric tube to identify anastomosis dehiscence, use of CPP as a source of canine albumin, and antimicrobial CRI in a dog with septic peritonitis.

Clinical features and outcome of septic shock in dogs: 37 Cases (2008‐2015)

“…We showed that survivors received approximately 4 interventions out of 7 possible, whereas nonsurvivors received approximately 2 of those interventions, although there were not enough data to decipher a further breakdown of the bundle. 9 Our data support, specifically, that early antimicrobial administration is beneficial in septic shock patients, with patient whom received antimicrobials within 3 hours having a 35% survival rate, which is close to the current survival rate in people. 12 There is a significant amount of data in both the human and veterinary literature suggesting that early and appropriate antimicrobial therapy is an important determinant of outcome in septic patients.…”

“…Our current study investigated the impact of interventions that have been linked to an improved outcome in humans suffering from septic shock or may be beneficial for those patients in a bundle approach. We showed that survivors received approximately 4 interventions out of 7 possible, whereas nonsurvivors received approximately 2 of those interventions, although there were not enough data to decipher a further breakdown of the bundle 9 …”

“…The Surviving Sepsis Campaign guidelines and treatment bundles described in the human literature have guided much of the course of treatment for veterinary patients. [9][10][11]25 The advent of the guidelines and bundles are meant to serve as a guide for clinicians to take certain courses of actions and implement treatment plans within the first several hours of septic shock recognition. It has been shown in human medicine that implementation of bundles can improve outcome.…”

“…Cryopoor plasma has been used in a septic shock dog and may be an alternative source of albumin for oncotic support. 9,39 Few large-scale studies of canine sepsis exist. A previous report of 114 dogs with sepsis identified multiple organ dysfunction as a negative predictor of outcome in dogs with sepsis.…”

“…1,[3][4][5][6][7][8] Available data on dogs with septic shock include subsets of patients suffering from multi-organ dysfunction syndrome as well as case reports. [9][10][11] In a multicentric retrospective study published in 2010, septic dogs without organ dysfunction were found to have a survival rate of 84%, compared to 46% survival rate if they had dysfunction of 2 organ systems, and 10% if they had hypotension sufficiently severe to require vasopressor therapy. 10 This is compared to reported mortality rates in people ranging from 13% to 72%.…”